ID   FABI_RICBR              Reviewed;         262 AA.
AC   Q1RH28;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-MAY-2006, sequence version 1.
DT   16-JUN-2009, entry version 28.
DE   RecName: Full=Enoyl-[acyl-carrier-protein] reductase [NADH];
DE            EC=1.3.1.9;
DE   AltName: Full=NADH-dependent enoyl-ACP reductase;
GN   Name=fabI; OrderedLocusNames=RBE_1255;
OS   Rickettsia bellii (strain RML369-C).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia.
OX   NCBI_TaxID=336407;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16703114; DOI=10.1371/journal.pgen.0020076;
RA   Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C.,
RA   Fournier P.-E., Claverie J.-M., Raoult D.;
RT   "Genome sequence of Rickettsia bellii illuminates the role of amoebae
RT   in gene exchanges between intracellular pathogens.";
RL   PLoS Genet. 2:733-744(2006).
CC   -!- CATALYTIC ACTIVITY: Acyl-[acyl-carrier-protein] + NAD(+) = trans-
CC       2,3-dehydroacyl-[acyl-carrier-protein] + NADH.
CC   -!- PATHWAY: Lipid metabolism; fatty acid biosynthesis.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane; Peripheral membrane
CC       protein (By similarity).
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases
CC       (SDR) family. FabI subfamily.
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DR   EMBL; CP000087; ABE05336.1; -; Genomic_DNA.
DR   RefSeq; YP_538425.1; -.
DR   GeneID; 3995181; -.
DR   GenomeReviews; CP000087_GR; RBE_1255.
DR   KEGG; rbe:RBE_1255; -.
DR   HOGENOM; Q1RH28; -.
DR   OMA; Q1RH28; LVHCLAF.
DR   BioCyc; RBEL336407:RBE_1255-MON; -.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005488; F:binding; IEA:InterPro.
DR   GO; GO:0004318; F:enoyl-[acyl-carrier-protein] reductase (NAD...; IEA:EC.
DR   GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR002198; DH_sc/Rdtase_SDR.
DR   InterPro; IPR014358; Enoyl-ACP_Rdtase_NADH.
DR   InterPro; IPR002347; Glc/ribitol_DH.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   PANTHER; PTHR19410; ADH_short_C2; 1.
DR   PANTHER; PTHR19410:SF12; Enoyl-ACP_rdct; 1.
DR   PRINTS; PR00081; GDHRDH.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Complete proteome;
KW   Fatty acid biosynthesis; Lipid synthesis; Membrane; NAD;
KW   Oxidoreductase.
FT   CHAIN         1    262       Enoyl-[acyl-carrier-protein] reductase
FT                                [NADH].
FT                                /FTId=PRO_0000286635.
FT   NP_BIND      12     38       NAD (By similarity).
FT   ACT_SITE    157    157       Proton acceptor (By similarity).
SQ   SEQUENCE   262 AA;  28415 MW;  5C7297DF2D4472FB CRC64;
     MTTGLLQGKR GIITGIANNM SISWAIAQLA RKHGAELCFT YQSEILEKRV KPLAEEVGCN
     FVSELDVTNP ESITNLFAEV KEKWGTFDFL LHGMAFSDRN ELKGRYIDTS LGNFNNSLHI
     SCYSLVELAR EAEKLMNDGG SIVTLSYYGA EKVIPNYNVM GVAKAALEAS VRYLANDMGE
     NNIRVNAISA GPIKTLSGSV IGDFNSMLRS HAATAPLKRN TLQQDVAGAA VYLFSQLASG
     VTGEIHYVDC GYNVMGSNKI VG
//