Reviewed, UniProtKB/Swiss-Prot Q1RH28 (FABI_RICBR)

Names and origin

Protein names

Recommended name:
    Enoyl-[acyl-carrier-protein] reductase [NADH]
    EC=1.3.1.9
Alternative name(s):
    NADH-dependent enoyl-ACP reductase

Gene names

Name:	fabI
Ordered Locus Names:	RBE_1255

Organism

Rickettsia bellii (strain RML369-C) [Complete proteome] [HAMAP]

Taxonomic identifier

336407 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia

Protein attributes

Sequence length	262 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Acyl-[acyl-carrier-protein] + NAD+ = trans-2,3-dehydroacyl-[acyl-carrier-protein] + NADH.
Pathway	Lipid metabolism; fatty acid biosynthesis.
Subcellular location	Cell inner membrane; Peripheral membrane protein By similarity.
Sequence similarities	Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.

Ontologies

Keywords
Biological process	Fatty acid biosynthesis Lipid synthesis
Cellular component	Cell inner membrane Cell membrane Membrane
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	fatty acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	binding Inferred from electronic annotation. Source: InterPro enoyl-[acyl-carrier-protein] reductase (NADH) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 262	262	Enoyl-[acyl-carrier-protein] reductase [NADH]		PRO_0000286635
Regions
	Nucleotide binding	12 – 38	27	NAD By similarity
Sites
	Active site	157	1	Proton acceptor By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q1RH28-1 [UniParc]. Last modified May 16, 2006. Version 1. Checksum: 5C7297DF2D4472FB	FASTA	262	28,415
	10 20 30 40 50 60 MTTGLLQGKR GIITGIANNM SISWAIAQLA RKHGAELCFT YQSEILEKRV KPLAEEVGCN 70 80 90 100 110 120 FVSELDVTNP ESITNLFAEV KEKWGTFDFL LHGMAFSDRN ELKGRYIDTS LGNFNNSLHI 130 140 150 160 170 180 SCYSLVELAR EAEKLMNDGG SIVTLSYYGA EKVIPNYNVM GVAKAALEAS VRYLANDMGE 190 200 210 220 230 240 NNIRVNAISA GPIKTLSGSV IGDFNSMLRS HAATAPLKRN TLQQDVAGAA VYLFSQLASG 250 260 VTGEIHYVDC GYNVMGSNKI VG

References

[1]

"Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens." Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D. PLoS Genet. 2:733-744(2006) [PubMed: 16703114] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000087 Genomic DNA. Translation: ABE05336.1.
RefSeq	YP_538425.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3995181.
GenomeReviews	Gene locus RBE_1255 in contig CP000087_GR.
KEGG	rbe:RBE_1255.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q1RH28.
OMA	Q1RH28. LVHCLAF.
Enzyme and pathway databases
BioCyc	RBEL336407:RBE_1255-MON.
Family and domain databases
InterPro	IPR002198. DH_sc/Rdtase_SDR. IPR014358. Enoyl-ACP_Rdtase_NADH. IPR002347. Glc/ribitol_DH. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR19410. ADH_short_C2. 1 hit. PTHR19410:SF12. Enoyl-ACP_rdct. 1 hit.
PRINTS	PR00081. GDHRDH.
ProtoNet	Search...

Entry information

Entry name

FABI_RICBR

Accession

Primary (citable) accession number: Q1RH28

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 15, 2007
Last sequence update:	May 16, 2006
Last modified:	June 16, 2009
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)