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Reviewed, UniProtKB/Swiss-Prot Q1RH28 (FABI_RICBR)

Last modified January 19, 2010. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Enoyl-[acyl-carrier-protein] reductase [NADH]
    EC=1.3.1.9
Alternative name(s):
    NADH-dependent enoyl-ACP reductase
Gene names
Name: fabI
Ordered Locus Names: RBE_1255
OrganismRickettsia bellii (strain RML369-C) [Complete proteome] [HAMAP]
Taxonomic identifier336407 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsia

Protein attributes

Sequence length262 AA.
Sequence statusComplete.
Protein existenceInferred from homology.

General annotation (Comments)

Catalytic activity

Acyl-[acyl-carrier-protein] + NAD+ = trans-2,3-dehydroacyl-[acyl-carrier-protein] + NADH.

Pathway

Lipid metabolism; fatty acid biosynthesis.

Subcellular location

Cell inner membrane; Peripheral membrane protein By similarity.

Sequence similarities

Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 262262Enoyl-[acyl-carrier-protein] reductase [NADH]
PRO_0000286635

Regions

Nucleotide binding12 – 3827NAD By similarity

Sites

Active site1571Proton acceptor By similarity

Sequences

Sequence LengthMass (Da)Tools
Q1RH28-1 [UniParc].

Last modified May 16, 2006. Version 1.
Checksum: 5C7297DF2D4472FB

FASTA26228,415
        10         20         30         40         50         60 
MTTGLLQGKR GIITGIANNM SISWAIAQLA RKHGAELCFT YQSEILEKRV KPLAEEVGCN 

        70         80         90        100        110        120 
FVSELDVTNP ESITNLFAEV KEKWGTFDFL LHGMAFSDRN ELKGRYIDTS LGNFNNSLHI 

       130        140        150        160        170        180 
SCYSLVELAR EAEKLMNDGG SIVTLSYYGA EKVIPNYNVM GVAKAALEAS VRYLANDMGE 

       190        200        210        220        230        240 
NNIRVNAISA GPIKTLSGSV IGDFNSMLRS HAATAPLKRN TLQQDVAGAA VYLFSQLASG 

       250        260 
VTGEIHYVDC GYNVMGSNKI VG 

« Hide

References

[1]"Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens."
Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D.
PLoS Genet. 2:733-744(2006) [PubMed: 16703114] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000087 Genomic DNA. Translation: ABE05336.1.
RefSeqYP_538425.1.

3D structure databases

SMRQ1RH28. Positions 4-258.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ1RH28.

Genome annotation databases

GeneID3995181.
GenomeReviewsGene locus RBE_1255 in contig CP000087_GR.
KEGGrbe:RBE_1255.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0623.
HOGENOMHBG750976.
OMALVHCLAF.

Enzyme and pathway databases

BioCycRBEL336407:RBE_1255-MONOMER.

Family and domain databases

InterProIPR002198. DH_sc/Rdtase_SDR.
IPR014358. Enoyl-ACP_Rdtase_NADH.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHERPTHR19410. ADH_short_C2. 1 hit.
PTHR19410:SF12. Enoyl-ACP_rdct. 1 hit.
PfamPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSPR00081. GDHRDH.
ProtoNetSearch...

Entry information

Entry nameFABI_RICBR
AccessionPrimary (citable) accession number: Q1RH28
Entry history
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 16, 2006
Last modified: January 19, 2010
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

Rickettsia bellii strain RML369-C

Rickettsia bellii (strain RML369-C): entries and gene names

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents