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Q1RH28 (FABI_RICBR) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI
Short name=ENR
EC=1.3.1.9
Alternative name(s):
NADH-dependent enoyl-ACP reductase
Gene names
Name:fabI
Ordered Locus Names:RBE_1255
OrganismRickettsia bellii (strain RML369-C) [Complete proteome] [HAMAP]
Taxonomic identifier336407 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › belli group ›

Protein attributes

Sequence length262 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP). Involved in the elongation cycle of fatty acid which are used in the lipid metabolism By similarity.

Catalytic activity

Acyl-[acyl-carrier-protein] + NAD+ = trans-2,3-dehydroacyl-[acyl-carrier-protein] + NADH.

Pathway

Lipid metabolism; fatty acid biosynthesis.

Subunit structure

Homotetramer By similarity.

Sequence similarities

Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 262262Enoyl-[acyl-carrier-protein] reductase [NADH] FabI
PRO_0000286635

Regions

Nucleotide binding21 – 222NAD By similarity
Nucleotide binding66 – 672NAD By similarity
Nucleotide binding193 – 1975NAD By similarity

Sites

Active site1471Proton acceptor By similarity
Active site1571Proton acceptor By similarity
Binding site151NAD; via carbonyl oxygen By similarity
Binding site421NAD By similarity
Binding site941NAD; via carbonyl oxygen By similarity
Binding site971Substrate; via amide nitrogen and carbonyl oxygen By similarity
Binding site1641NAD By similarity
Site2051Involved in acyl-ACP binding By similarity

Sequences

Sequence LengthMass (Da)Tools
Q1RH28 [UniParc].

Last modified May 16, 2006. Version 1.
Checksum: 5C7297DF2D4472FB

FASTA26228,415
        10         20         30         40         50         60 
MTTGLLQGKR GIITGIANNM SISWAIAQLA RKHGAELCFT YQSEILEKRV KPLAEEVGCN 

        70         80         90        100        110        120 
FVSELDVTNP ESITNLFAEV KEKWGTFDFL LHGMAFSDRN ELKGRYIDTS LGNFNNSLHI 

       130        140        150        160        170        180 
SCYSLVELAR EAEKLMNDGG SIVTLSYYGA EKVIPNYNVM GVAKAALEAS VRYLANDMGE 

       190        200        210        220        230        240 
NNIRVNAISA GPIKTLSGSV IGDFNSMLRS HAATAPLKRN TLQQDVAGAA VYLFSQLASG 

       250        260 
VTGEIHYVDC GYNVMGSNKI VG

« Hide

References

[1]"Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens."
Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D.
PLoS Genet. 2:733-744(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: RML369-C.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000087 Genomic DNA. Translation: ABE05336.1.
RefSeqYP_538425.1. NC_007940.1.

3D structure databases

ProteinModelPortalQ1RH28.
ModBaseSearch...

Protein-protein interaction databases

STRING336407.RBE_1255.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABE05336; ABE05336; RBE_1255.
GeneID3995181.
KEGGrbe:RBE_1255.
PATRIC17884136. VBIRicBel102610_1417.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0623.
KOK00208.
OMALVHCLAF.
ProtClustDBPRK06603.

Enzyme and pathway databases

BioCycRBEL336407:GJCY-1292-MONOMER.
UniPathwayUPA00094.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
InterProIPR014358. Enoyl-ACP_Rdtase_NADH.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PIRSFPIRSF000094. Enoyl-ACP_rdct. 1 hit.
PRINTSPR00081. GDHRDH.
ProtoNetSearch...

Entry information

Entry nameFABI_RICBR
AccessionPrimary (citable) accession number: Q1RH28
Entry history
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 16, 2006
Last modified: May 1, 2013
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Rickettsia bellii strain RML369-C

Rickettsia bellii (strain RML369-C): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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