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Q1RGZ7

- TSAE_RICBR

UniProt

Q1RGZ7 - TSAE_RICBR

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Protein
tRNA threonylcarbamoyladenosine biosynthesis protein TsaE
Gene
tsaE, RBE_1286
Organism
Rickettsia bellii (strain RML369-C)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t6A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaD and TsaB. TsaE seems to play an indirect role in the t6A biosynthesis pathway, possibly in regulating the core enzymatic function of TsaD By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei13 – 131ATP By similarity
Metal bindingi44 – 441Magnesium By similarity
Metal bindingi110 – 1101Magnesium By similarity
Binding sitei133 – 1331ATP; via carbonyl oxygen By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi40 – 456ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. threonylcarbamoyladenosine biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRBEL336407:GJCY-1324-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA threonylcarbamoyladenosine biosynthesis protein TsaE
Alternative name(s):
t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaE
Gene namesi
Name:tsaE
Ordered Locus Names:RBE_1286
OrganismiRickettsia bellii (strain RML369-C)
Taxonomic identifieri336407 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group
ProteomesiUP000001951: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 144144tRNA threonylcarbamoyladenosine biosynthesis protein TsaE
PRO_0000281041Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi336407.RBE_1286.

Structurei

3D structure databases

ProteinModelPortaliQ1RGZ7.

Family & Domainsi

Sequence similaritiesi

Belongs to the TsaE family.

Phylogenomic databases

eggNOGiCOG0802.
HOGENOMiHOG000052239.
KOiK06925.
OMAiNERSICL.
OrthoDBiEOG6GBMHT.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR003442. T6A_TsaE.
[Graphical view]
PfamiPF02367. UPF0079. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00150. T6A_YjeE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1RGZ7-1 [UniParc]FASTAAdd to Basket

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MQMLNSQTIL NSEEETKNFA KAFAATLKPN NIVLLNGDLG VGKTFFCREI    50
IKYFCGENTS IISPTFNLLQ TYKTPHFTIY HCDLYRLKSP EEIYELGLEE 100
ALSGNLTLIE WSEIIKHLLP TPLIEVNLKL LDDDKRLCNI TNEY 144
Length:144
Mass (Da):16,548
Last modified:May 16, 2006 - v1
Checksum:i7B1FBFFA3BC58546
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000087 Genomic DNA. Translation: ABE05367.1.
RefSeqiYP_538456.1. NC_007940.1.

Genome annotation databases

EnsemblBacteriaiABE05367; ABE05367; RBE_1286.
GeneIDi3994898.
KEGGirbe:RBE_1286.
PATRICi17884204. VBIRicBel102610_1450.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000087 Genomic DNA. Translation: ABE05367.1 .
RefSeqi YP_538456.1. NC_007940.1.

3D structure databases

ProteinModelPortali Q1RGZ7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 336407.RBE_1286.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABE05367 ; ABE05367 ; RBE_1286 .
GeneIDi 3994898.
KEGGi rbe:RBE_1286.
PATRICi 17884204. VBIRicBel102610_1450.

Phylogenomic databases

eggNOGi COG0802.
HOGENOMi HOG000052239.
KOi K06925.
OMAi NERSICL.
OrthoDBi EOG6GBMHT.

Enzyme and pathway databases

BioCyci RBEL336407:GJCY-1324-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR027417. P-loop_NTPase.
IPR003442. T6A_TsaE.
[Graphical view ]
Pfami PF02367. UPF0079. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00150. T6A_YjeE. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens."
    Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D.
    PLoS Genet. 2:733-744(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RML369-C.

Entry informationi

Entry nameiTSAE_RICBR
AccessioniPrimary (citable) accession number: Q1RGZ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: May 16, 2006
Last modified: May 14, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia bellii strain RML369-C
    Rickettsia bellii (strain RML369-C): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi