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Q1RGZ7

- TSAE_RICBR

UniProt

Q1RGZ7 - TSAE_RICBR

Protein

tRNA threonylcarbamoyladenosine biosynthesis protein TsaE

Gene

tsaE

Organism
Rickettsia bellii (strain RML369-C)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (16 May 2006)
      Previous versions | rss
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    Functioni

    Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t6A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaD and TsaB. TsaE seems to play an indirect role in the t6A biosynthesis pathway, possibly in regulating the core enzymatic function of TsaD By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei13 – 131ATPBy similarity
    Metal bindingi44 – 441MagnesiumBy similarity
    Metal bindingi110 – 1101MagnesiumBy similarity
    Binding sitei133 – 1331ATP; via carbonyl oxygenBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi40 – 456ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. threonylcarbamoyladenosine biosynthetic process Source: InterPro

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciRBEL336407:GJCY-1324-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    tRNA threonylcarbamoyladenosine biosynthesis protein TsaE
    Alternative name(s):
    t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaE
    Gene namesi
    Name:tsaE
    Ordered Locus Names:RBE_1286
    OrganismiRickettsia bellii (strain RML369-C)
    Taxonomic identifieri336407 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group
    ProteomesiUP000001951: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 144144tRNA threonylcarbamoyladenosine biosynthesis protein TsaEPRO_0000281041Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi336407.RBE_1286.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1RGZ7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TsaE family.Curated

    Phylogenomic databases

    eggNOGiCOG0802.
    HOGENOMiHOG000052239.
    KOiK06925.
    OMAiNERSICL.
    OrthoDBiEOG6GBMHT.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR027417. P-loop_NTPase.
    IPR003442. T6A_TsaE.
    [Graphical view]
    PfamiPF02367. UPF0079. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00150. T6A_YjeE. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q1RGZ7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQMLNSQTIL NSEEETKNFA KAFAATLKPN NIVLLNGDLG VGKTFFCREI    50
    IKYFCGENTS IISPTFNLLQ TYKTPHFTIY HCDLYRLKSP EEIYELGLEE 100
    ALSGNLTLIE WSEIIKHLLP TPLIEVNLKL LDDDKRLCNI TNEY 144
    Length:144
    Mass (Da):16,548
    Last modified:May 16, 2006 - v1
    Checksum:i7B1FBFFA3BC58546
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000087 Genomic DNA. Translation: ABE05367.1.
    RefSeqiYP_538456.1. NC_007940.1.

    Genome annotation databases

    EnsemblBacteriaiABE05367; ABE05367; RBE_1286.
    GeneIDi3994898.
    KEGGirbe:RBE_1286.
    PATRICi17884204. VBIRicBel102610_1450.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000087 Genomic DNA. Translation: ABE05367.1 .
    RefSeqi YP_538456.1. NC_007940.1.

    3D structure databases

    ProteinModelPortali Q1RGZ7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 336407.RBE_1286.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABE05367 ; ABE05367 ; RBE_1286 .
    GeneIDi 3994898.
    KEGGi rbe:RBE_1286.
    PATRICi 17884204. VBIRicBel102610_1450.

    Phylogenomic databases

    eggNOGi COG0802.
    HOGENOMi HOG000052239.
    KOi K06925.
    OMAi NERSICL.
    OrthoDBi EOG6GBMHT.

    Enzyme and pathway databases

    BioCyci RBEL336407:GJCY-1324-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR027417. P-loop_NTPase.
    IPR003442. T6A_TsaE.
    [Graphical view ]
    Pfami PF02367. UPF0079. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00150. T6A_YjeE. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens."
      Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D.
      PLoS Genet. 2:733-744(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RML369-C.

    Entry informationi

    Entry nameiTSAE_RICBR
    AccessioniPrimary (citable) accession number: Q1RGZ7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 20, 2007
    Last sequence update: May 16, 2006
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Rickettsia bellii strain RML369-C
      Rickettsia bellii (strain RML369-C): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3