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Q1RGZ7 (TSAE_RICBR) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
tRNA threonylcarbamoyladenosine biosynthesis protein TsaE
Alternative name(s):
t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaE
Gene names
Name:tsaE
Ordered Locus Names:RBE_1286
OrganismRickettsia bellii (strain RML369-C) [Complete proteome] [HAMAP]
Taxonomic identifier336407 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group

Protein attributes

Sequence length144 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t6A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaD and TsaB. TsaE seems to play an indirect role in the t6A biosynthesis pathway, possibly in regulating the core enzymatic function of TsaD By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the TsaE family.

Ontologies

Keywords
   Biological processtRNA processing
   Cellular componentCytoplasm
   LigandATP-binding
Magnesium
Metal-binding
Nucleotide-binding
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processthreonylcarbamoyladenosine biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 144144tRNA threonylcarbamoyladenosine biosynthesis protein TsaE
PRO_0000281041

Regions

Nucleotide binding40 – 456ATP By similarity

Sites

Metal binding441Magnesium By similarity
Metal binding1101Magnesium By similarity
Binding site131ATP By similarity
Binding site1331ATP; via carbonyl oxygen By similarity

Sequences

Sequence LengthMass (Da)Tools
Q1RGZ7 [UniParc].

Last modified May 16, 2006. Version 1.
Checksum: 7B1FBFFA3BC58546

FASTA14416,548
        10         20         30         40         50         60 
MQMLNSQTIL NSEEETKNFA KAFAATLKPN NIVLLNGDLG VGKTFFCREI IKYFCGENTS 

        70         80         90        100        110        120 
IISPTFNLLQ TYKTPHFTIY HCDLYRLKSP EEIYELGLEE ALSGNLTLIE WSEIIKHLLP 

       130        140 
TPLIEVNLKL LDDDKRLCNI TNEY 

« Hide

References

[1]"Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens."
Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D.
PLoS Genet. 2:733-744(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: RML369-C.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000087 Genomic DNA. Translation: ABE05367.1.
RefSeqYP_538456.1. NC_007940.1.

3D structure databases

ProteinModelPortalQ1RGZ7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING336407.RBE_1286.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABE05367; ABE05367; RBE_1286.
GeneID3994898.
KEGGrbe:RBE_1286.
PATRIC17884204. VBIRicBel102610_1450.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0802.
HOGENOMHOG000052239.
KOK06925.
OMANERSICL.
OrthoDBEOG6GBMHT.

Enzyme and pathway databases

BioCycRBEL336407:GJCY-1324-MONOMER.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR027417. P-loop_NTPase.
IPR003442. T6A_TsaE.
[Graphical view]
PfamPF02367. UPF0079. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00150. T6A_YjeE. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTSAE_RICBR
AccessionPrimary (citable) accession number: Q1RGZ7
Entry history
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: May 16, 2006
Last modified: May 14, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia bellii strain RML369-C

Rickettsia bellii (strain RML369-C): entries and gene names