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Q1RGY9

- QUEF_RICBR

UniProt

Q1RGY9 - QUEF_RICBR

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Protein

NADPH-dependent 7-cyano-7-deazaguanine reductase

Gene

queF

Organism
Rickettsia bellii (strain RML369-C)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).UniRule annotation

Catalytic activityi

7-aminomethyl-7-carbaguanine + 2 NADP+ = 7-cyano-7-carbaguanine + 2 NADPH.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei179 – 1791Thioimide intermediateUniRule annotation
Active sitei186 – 1861Proton donorUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi83 – 842NADPHUniRule annotation
Nucleotide bindingi247 – 2482NADPHUniRule annotation

GO - Molecular functioni

  1. oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor Source: InterPro
  2. preQ1 synthase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. queuosine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Queuosine biosynthesis

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciRBEL336407:GJCY-1332-MONOMER.
UniPathwayiUPA00392.

Names & Taxonomyi

Protein namesi
Recommended name:
NADPH-dependent 7-cyano-7-deazaguanine reductaseUniRule annotation (EC:1.7.1.13UniRule annotation)
Alternative name(s):
7-cyano-7-carbaguanine reductaseUniRule annotation
NADPH-dependent nitrile oxidoreductaseUniRule annotation
PreQ(0) reductaseUniRule annotation
Gene namesi
Name:queFUniRule annotation
Ordered Locus Names:RBE_1294
OrganismiRickettsia bellii (strain RML369-C)
Taxonomic identifieri336407 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group
ProteomesiUP000001951: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 273273NADPH-dependent 7-cyano-7-deazaguanine reductasePRO_0000247717Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi336407.RBE_1294.

Structurei

3D structure databases

ProteinModelPortaliQ1RGY9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni81 – 833Substrate bindingUniRule annotation
Regioni218 – 2192Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the GTP cyclohydrolase I family. QueF type 2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0780.
HOGENOMiHOG000273755.
KOiK06879.
OMAiIFCDLMH.
OrthoDBiEOG6D5G0M.

Family and domain databases

HAMAPiMF_00817. QueF_type2.
InterProiIPR029500. QueF.
IPR029139. QueF_N.
IPR016428. QueF_type2.
[Graphical view]
PfamiPF14489. QueF. 1 hit.
PF14819. QueF_N. 1 hit.
[Graphical view]
PIRSFiPIRSF004750. Nitrile_oxidored_YqcD_prd. 1 hit.
TIGRFAMsiTIGR03138. QueF. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1RGY9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTLSNSALGK KSTYKDTYDP TLLFKIPRID NRKELGIVND KLPFHGVDIW
60 70 80 90 100
NAYELSWLDK KGKPCVAIFT FFVPTTSSHI VESKSVKLYL NSFNNFVVDS
110 120 130 140 150
MEELKRTILQ DLSNNTHAEV TGEIFPINTK IEFGSPTGIN IDDIDIECSE
160 170 180 190 200
YGPPNNSLIK HEDVLVEEEL NSNLLKSNCL VTGQPDWGTI IIKYKGKKLK
210 220 230 240 250
HDALLKYLVS FRNCNEFAEQ CAERIFTDIK NAINPEFLSI YIIYTRRGGI
260 270
DICPYRSTDS NYTLPSSKRL IRQ
Length:273
Mass (Da):31,146
Last modified:May 16, 2006 - v1
Checksum:i70548EE9DDC193D3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000087 Genomic DNA. Translation: ABE05375.1.
RefSeqiWP_011477945.1. NC_007940.1.
YP_538464.1. NC_007940.1.

Genome annotation databases

EnsemblBacteriaiABE05375; ABE05375; RBE_1294.
GeneIDi3995983.
KEGGirbe:RBE_1294.
PATRICi17884222. VBIRicBel102610_1459.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000087 Genomic DNA. Translation: ABE05375.1 .
RefSeqi WP_011477945.1. NC_007940.1.
YP_538464.1. NC_007940.1.

3D structure databases

ProteinModelPortali Q1RGY9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 336407.RBE_1294.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABE05375 ; ABE05375 ; RBE_1294 .
GeneIDi 3995983.
KEGGi rbe:RBE_1294.
PATRICi 17884222. VBIRicBel102610_1459.

Phylogenomic databases

eggNOGi COG0780.
HOGENOMi HOG000273755.
KOi K06879.
OMAi IFCDLMH.
OrthoDBi EOG6D5G0M.

Enzyme and pathway databases

UniPathwayi UPA00392 .
BioCyci RBEL336407:GJCY-1332-MONOMER.

Family and domain databases

HAMAPi MF_00817. QueF_type2.
InterProi IPR029500. QueF.
IPR029139. QueF_N.
IPR016428. QueF_type2.
[Graphical view ]
Pfami PF14489. QueF. 1 hit.
PF14819. QueF_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF004750. Nitrile_oxidored_YqcD_prd. 1 hit.
TIGRFAMsi TIGR03138. QueF. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens."
    Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D.
    PLoS Genet. 2:733-744(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RML369-C.

Entry informationi

Entry nameiQUEF_RICBR
AccessioniPrimary (citable) accession number: Q1RGY9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: May 16, 2006
Last modified: November 26, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Rickettsia bellii strain RML369-C
    Rickettsia bellii (strain RML369-C): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3