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Q1RGX7 (Q1RGX7_RICBR) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Endonuclease III HAMAP-Rule MF_00942

EC=4.2.99.18 HAMAP-Rule MF_00942
Alternative name(s):
DNA-(apurinic or apyrimidinic site) lyase HAMAP-Rule MF_00942
Gene names
Name:nth HAMAP-Rule MF_00942 EMBL ABE05387.1
Ordered Locus Names:RBE_1306 EMBL ABE05387.1
OrganismRickettsia bellii (strain RML369-C) [Complete proteome] [HAMAP] EMBL ABE05387.1
Taxonomic identifier336407 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group

Protein attributes

Sequence length315 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate By similarity. HAMAP-Rule MF_00942

Catalytic activity

The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. HAMAP-Rule MF_00942

Cofactor

Binds 1 4Fe-4S cluster By similarity. HAMAP-Rule MF_00942

Sequence similarities

Belongs to the Nth/MutY family. HAMAP-Rule MF_00942

Contains 1 HhH domain. HAMAP-Rule MF_00942

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain202 – 22928HhH By similarity HAMAP-Rule MF_00942

Sites

Metal binding2891Iron-sulfur (4Fe-4S) By similarity HAMAP-Rule MF_00942
Metal binding2961Iron-sulfur (4Fe-4S) By similarity HAMAP-Rule MF_00942
Metal binding2991Iron-sulfur (4Fe-4S) By similarity HAMAP-Rule MF_00942
Metal binding3051Iron-sulfur (4Fe-4S) By similarity HAMAP-Rule MF_00942

Sequences

Sequence LengthMass (Da)Tools
Q1RGX7 [UniParc].

Last modified May 16, 2006. Version 1.
Checksum: 03575C9BCD220E9D

FASTA31535,162
        10         20         30         40         50         60 
MSQPPTNSPL IYNCGNVGQS LKTFKDSRNS GSDNTSISRN STPSLVKIIT TLPENPHIGA 

        70         80         90        100        110        120 
SLVPFMNNTT LLFFISFSIN LKLLFSNIKN LICLILFVTL YTMQAEIVNK IFEVFSKNNE 

       130        140        150        160        170        180 
NPKTELVYKN NFTLLVAVIL SAQATDVSVN LATKSLFEIY DTPEKILGLG EEGLKKYIKS 

       190        200        210        220        230        240 
IGLFNSKAKN VIALCQILIS NYDSKVPNNF EELVKLPGVG RKTANVVLNC LFGLPTMAVD 

       250        260        270        280        290        300 
THVFRVAKRI GLAKGNTPEA VEKELLQIID GKWLSHAHHW LILHGRYICK ARKPDCEICP 

       310 
IKEYCEYYKS ATKII 

« Hide

References

[1]"Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens."
Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.E., Claverie J.M., Raoult D.
PLoS Genet. 2:E76-E76(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: RML369-C EMBL ABE05387.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000087 Genomic DNA. Translation: ABE05387.1.
RefSeqYP_538476.1. NC_007940.1.

3D structure databases

ProteinModelPortalQ1RGX7.
SMRQ1RGX7. Positions 106-311.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING336407.RBE_1306.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABE05387; ABE05387; RBE_1306.
GeneID3995523.
KEGGrbe:RBE_1306.
PATRIC17884246. VBIRicBel102610_1471.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0177.
HOGENOMHOG000252206.
KOK10773.
OMAGECEMIE.
OrthoDBEOG6H4KC5.

Enzyme and pathway databases

BioCycRBEL336407:GJCY-1344-MONOMER.

Family and domain databases

Gene3D1.10.1670.10. 1 hit.
1.10.340.30. 1 hit.
HAMAPMF_00942. Nth.
InterProIPR011257. DNA_glycosylase.
IPR004036. Endonuclease-III-like_CS2.
IPR003651. Endouclease3_FeS-loop_motif.
IPR003265. HhH-GPD_domain.
IPR000445. HhH_motif.
IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
IPR023170. HTH_base_excis_C.
IPR005759. Nth.
[Graphical view]
PfamPF10576. EndIII_4Fe-2S. 1 hit.
PF00633. HHH. 1 hit.
PF00730. HhH-GPD. 1 hit.
[Graphical view]
SMARTSM00478. ENDO3c. 1 hit.
SM00525. FES. 1 hit.
SM00278. HhH1. 1 hit.
[Graphical view]
SUPFAMSSF48150. SSF48150. 1 hit.
TIGRFAMsTIGR01083. nth. 1 hit.
PROSITEPS01155. ENDONUCLEASE_III_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ1RGX7_RICBR
AccessionPrimary (citable) accession number: Q1RGX7
Entry history
Integrated into UniProtKB/TrEMBL: May 16, 2006
Last sequence update: May 16, 2006
Last modified: July 9, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)