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Protein

Endonuclease III

Gene

nth

Organism
Rickettsia bellii (strain RML369-C)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.UniRule annotation

Catalytic activityi

The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.UniRule annotation

Cofactori

[4Fe-4S] clusterUniRule annotationNote: Binds 1 [4Fe-4S] cluster.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi289Iron-sulfur (4Fe-4S)UniRule annotation1
Metal bindingi296Iron-sulfur (4Fe-4S)UniRule annotation1
Metal bindingi299Iron-sulfur (4Fe-4S)UniRule annotation1
Metal bindingi305Iron-sulfur (4Fe-4S)UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingUniRule annotation, EndonucleaseImported, GlycosidaseUniRule annotation, Hydrolase, LyaseUniRule annotationImported, Nuclease
Biological processDNA damage, DNA repairUniRule annotation
Ligand4Fe-4SUniRule annotation, Iron, Iron-sulfur, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Endonuclease IIIUniRule annotation (EC:4.2.99.18UniRule annotation)
Alternative name(s):
DNA-(apurinic or apyrimidinic site) lyaseUniRule annotation
Gene namesi
Name:nthUniRule annotationImported
Ordered Locus Names:RBE_1306Imported
OrganismiRickettsia bellii (strain RML369-C)Imported
Taxonomic identifieri336407 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group
Proteomesi
  • UP000001951 Componenti: Chromosome

Structurei

3D structure databases

ProteinModelPortaliQ1RGX7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini140 – 287ENDO3cInterPro annotationAdd BLAST148

Sequence similaritiesi

Belongs to the Nth/MutY family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000252206.
KOiK10773.
OMAiCKALIAP.
OrthoDBiPOG091H021U.

Family and domain databases

CDDicd00056. ENDO3c. 1 hit.
Gene3Di1.10.1670.10. 1 hit.
HAMAPiMF_00942. Nth. 1 hit.
InterProiView protein in InterPro
IPR011257. DNA_glycosylase.
IPR004036. Endonuclease-III-like_CS2.
IPR003651. Endonuclease3_FeS-loop_motif.
IPR003265. HhH-GPD_domain.
IPR000445. HhH_motif.
IPR023170. HTH_base_excis_C.
IPR005759. Nth.
PfamiView protein in Pfam
PF10576. EndIII_4Fe-2S. 1 hit.
PF00633. HHH. 1 hit.
PF00730. HhH-GPD. 1 hit.
SMARTiView protein in SMART
SM00478. ENDO3c. 1 hit.
SM00525. FES. 1 hit.
SUPFAMiSSF48150. SSF48150. 1 hit.
TIGRFAMsiTIGR01083. nth. 1 hit.
PROSITEiView protein in PROSITE
PS01155. ENDONUCLEASE_III_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1RGX7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQPPTNSPL IYNCGNVGQS LKTFKDSRNS GSDNTSISRN STPSLVKIIT
60 70 80 90 100
TLPENPHIGA SLVPFMNNTT LLFFISFSIN LKLLFSNIKN LICLILFVTL
110 120 130 140 150
YTMQAEIVNK IFEVFSKNNE NPKTELVYKN NFTLLVAVIL SAQATDVSVN
160 170 180 190 200
LATKSLFEIY DTPEKILGLG EEGLKKYIKS IGLFNSKAKN VIALCQILIS
210 220 230 240 250
NYDSKVPNNF EELVKLPGVG RKTANVVLNC LFGLPTMAVD THVFRVAKRI
260 270 280 290 300
GLAKGNTPEA VEKELLQIID GKWLSHAHHW LILHGRYICK ARKPDCEICP
310
IKEYCEYYKS ATKII
Length:315
Mass (Da):35,162
Last modified:May 16, 2006 - v1
Checksum:i03575C9BCD220E9D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000087 Genomic DNA. Translation: ABE05387.1.

Genome annotation databases

EnsemblBacteriaiABE05387; ABE05387; RBE_1306.
KEGGirbe:RBE_1306.

Similar proteinsi

Entry informationi

Entry nameiQ1RGX7_RICBR
AccessioniPrimary (citable) accession number: Q1RGX7
Entry historyiIntegrated into UniProtKB/TrEMBL: May 16, 2006
Last sequence update: May 16, 2006
Last modified: October 25, 2017
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported