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Q1RGV8

- CISY_RICBR

UniProt

Q1RGV8 - CISY_RICBR

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Protein
Citrate synthase
Gene
gltA, RBE_1325
Organism
Rickettsia bellii (strain RML369-C)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei311 – 3111 By similarity
Active sitei370 – 3701 By similarity

GO - Molecular functioni

  1. citrate (Si)-synthase activity Source: InterPro

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Tricarboxylic acid cycle

Enzyme and pathway databases

BioCyciRBEL336407:GJCY-1363-MONOMER.
UniPathwayiUPA00223; UER00717.

Names & Taxonomyi

Protein namesi
Recommended name:
Citrate synthase (EC:2.3.3.16)
Gene namesi
Name:gltA
Ordered Locus Names:RBE_1325
OrganismiRickettsia bellii (strain RML369-C)
Taxonomic identifieri336407 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group
ProteomesiUP000001951: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 435435Citrate synthase
PRO_0000273146Add
BLAST

Proteomic databases

PRIDEiQ1RGV8.

Interactioni

Protein-protein interaction databases

STRINGi336407.RBE_1325.

Structurei

3D structure databases

ProteinModelPortaliQ1RGV8.
SMRiQ1RGV8. Positions 17-435.

Family & Domainsi

Sequence similaritiesi

Belongs to the citrate synthase family.

Phylogenomic databases

eggNOGiCOG0372.
HOGENOMiHOG000021224.
KOiK01647.
OMAiKETCDEV.
OrthoDBiEOG6P8TP4.

Family and domain databases

Gene3Di1.10.230.10. 1 hit.
1.10.580.10. 1 hit.
InterProiIPR016142. Citrate_synth-like_lrg_a-sub.
IPR016143. Citrate_synth-like_sm_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR024176. Citrate_synthase_bac-typ.
IPR010953. Citrate_synthase_typ-I.
[Graphical view]
PANTHERiPTHR11739. PTHR11739. 1 hit.
PfamiPF00285. Citrate_synt. 1 hit.
[Graphical view]
PIRSFiPIRSF001369. Citrate_synth. 1 hit.
PRINTSiPR00143. CITRTSNTHASE.
SUPFAMiSSF48256. SSF48256. 1 hit.
TIGRFAMsiTIGR01798. cit_synth_I. 1 hit.
PROSITEiPS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1RGV8-1 [UniParc]FASTAAdd to Basket

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MTSENNNTEF AELKIRDKIF KLPILKASIG QDVIDISKVY SEADCFTYDP    50
GFMSTASCRS TITYIDGDQG ILRHRGYDIK DLAEKSDFLE VAYLLIYGEL 100
PNNKQYNDFT KKVAHHALVN ERLHYLFQTF CSSSHPMAIM LAAVGSLSAF 150
YPDLLNFFKE ADYELTAIRM IAKIPTIAAM SYKYSIGQPF VYPDNSLDFT 200
ENFLHMMFAT PCEKYKVNPV IKNALNKIFI LHADHEQNAS TSTVRIAGSS 250
GANPFACVST GIASLWGPAH GGANEAVINM LKEIGSVENI PKYIAKAKDK 300
NDNFRLMGFG HRVYKNYDPR AAVLKETCKE VLKELGQLDN NPLLQIAIEL 350
EAIALKDEYF IERKLYPNVD FYSGIIYKAM GIPPQMFTVL FATARTVGWM 400
AQWKEMHEDP EQKISRPRQL YTGQVHREYK TIKER 435
Length:435
Mass (Da):49,385
Last modified:May 16, 2006 - v1
Checksum:i915B621AB5C5154F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000087 Genomic DNA. Translation: ABE05406.1.
RefSeqiYP_538495.1. NC_007940.1.

Genome annotation databases

EnsemblBacteriaiABE05406; ABE05406; RBE_1325.
GeneIDi3996133.
KEGGirbe:RBE_1325.
PATRICi17884294. VBIRicBel102610_1495.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000087 Genomic DNA. Translation: ABE05406.1 .
RefSeqi YP_538495.1. NC_007940.1.

3D structure databases

ProteinModelPortali Q1RGV8.
SMRi Q1RGV8. Positions 17-435.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 336407.RBE_1325.

Proteomic databases

PRIDEi Q1RGV8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABE05406 ; ABE05406 ; RBE_1325 .
GeneIDi 3996133.
KEGGi rbe:RBE_1325.
PATRICi 17884294. VBIRicBel102610_1495.

Phylogenomic databases

eggNOGi COG0372.
HOGENOMi HOG000021224.
KOi K01647.
OMAi KETCDEV.
OrthoDBi EOG6P8TP4.

Enzyme and pathway databases

UniPathwayi UPA00223 ; UER00717 .
BioCyci RBEL336407:GJCY-1363-MONOMER.

Family and domain databases

Gene3Di 1.10.230.10. 1 hit.
1.10.580.10. 1 hit.
InterProi IPR016142. Citrate_synth-like_lrg_a-sub.
IPR016143. Citrate_synth-like_sm_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR024176. Citrate_synthase_bac-typ.
IPR010953. Citrate_synthase_typ-I.
[Graphical view ]
PANTHERi PTHR11739. PTHR11739. 1 hit.
Pfami PF00285. Citrate_synt. 1 hit.
[Graphical view ]
PIRSFi PIRSF001369. Citrate_synth. 1 hit.
PRINTSi PR00143. CITRTSNTHASE.
SUPFAMi SSF48256. SSF48256. 1 hit.
TIGRFAMsi TIGR01798. cit_synth_I. 1 hit.
PROSITEi PS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens."
    Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D.
    PLoS Genet. 2:733-744(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RML369-C.

Entry informationi

Entry nameiCISY_RICBR
AccessioniPrimary (citable) accession number: Q1RGV8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: May 16, 2006
Last modified: September 3, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Citrate synthase is found in nearly all cells capable of oxidative metabolism.

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Rickettsia bellii strain RML369-C
    Rickettsia bellii (strain RML369-C): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi