Q1RGV0 (AAT_RICBR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aspartate aminotransferase
Short name=AspAT
EC=2.6.1.1

Alternative name(s):
Transaminase A

Gene names

Name:	aatA
Ordered Locus Names:	RBE_1333

Organism

Rickettsia bellii (strain RML369-C) [Complete proteome] [HAMAP]

Taxonomic identifier

336407 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia

Protein attributes

Sequence length	399 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.
Cofactor	Pyridoxal phosphate By similarity.
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Pyridoxal phosphate
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	1-aminocyclopropane-1-carboxylate synthase activity Inferred from electronic annotation. Source: InterPro L-aspartate:2-oxoglutarate aminotransferase activity Inferred from electronic annotation. Source: EC L-phenylalanine:2-oxoglutarate aminotransferase activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 399	399	Aspartate aminotransferase		PRO_0000273124
Sites
	Binding site	39	1	Aspartate; via amide nitrogen By similarity
	Binding site	125	1	Aspartate By similarity
	Binding site	175	1	Aspartate By similarity
	Binding site	375	1	Aspartate By similarity
Amino acid modifications
	Modified residue	239	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q1RGV0 [UniParc]. Last modified May 16, 2006. Version 1. Checksum: 09F007EFF3ABCE9A	FASTA	399	43,981
	10 20 30 40 50 60 MSIISTQLNA IKPSPTLAVV RKTLELKRAG IDIIALGAGE PDFDTPDNIK EAAIKAIKDG 70 80 90 100 110 120 FTKYTNVEGI PALKEAIQAK FKRENNIDYD LEEIIVSTGG KQVIYNLFMA SLNKGDEVII 130 140 150 160 170 180 PAPYWVSYPD MVLLAEGTPV FANCGIESNF KLSGEALEQL ITPKTKWLII NSPSNPTGAS 190 200 210 220 230 240 YSHSELKNIA EVLRKHPYVN VMSDDIYEHI TFDGFKFYTL AEIAPDLKDR IFTVNGVSKA 250 260 270 280 290 300 YSMTGWRIGY GAGSKALIKA MTIIQSQSTS NPCSISQVAA VEALNGVQGY IAQNALNFEK 310 320 330 340 350 360 KRDLALSILQ RVKYFECYKP EGAFYLFIKC DKIFGAKTKS GKVINNSNDF GEYLLEEAKV 370 380 390 AVVPGIAFGL EGYFRISYAT SMEELEEACL RMERACGSL

References

[1]

"Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens." Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D. PLoS Genet. 2:733-744(2006) [PubMed: 16703114] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: RML369-C.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000087 Genomic DNA. Translation: ABE05414.1.
RefSeq	YP_538503.1. NC_007940.1.
3D structure databases
ProteinModelPortal	Q1RGV0.
ModBase	Search...
Protein-protein interaction databases
STRING	Q1RGV0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3995813.
GenomeReviews	Gene locus RBE_1333 in contig CP000087_GR.
KEGG	rbe:RBE_1333.
PATRIC	17884314. VBIRicBel102610_1505.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0436.
HOGENOM	HBG645860.
OMA	MASLDKG.
ProtClustDB	PRK05764.
Enzyme and pathway databases
BioCyc	RBEL336407:RBE_1333-MONOMER.
Family and domain databases
InterPro	IPR001176. ACC_synthase. IPR004839. Aminotransferase_I/II. IPR004838. NHTrfase_class1_PyrdxlP-BS. IPR015424. PyrdxlP-dep_Trfase_major_dom. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit. G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 1 hit.
KO	K00812.
Pfam	PF00155. Aminotran_1_2. 1 hit. [Graphical view]
PRINTS	PR00753. ACCSYNTHASE.
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
PROSITE	PS00105. AA_TRANSFER_CLASS_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AAT_RICBR

Accession

Primary (citable) accession number: Q1RGV0

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2007
Last sequence update:	May 16, 2006
Last modified:	January 25, 2012
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program