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Protein

Alanine racemase

Gene

alr

Organism
Rickettsia bellii (strain RML369-C)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (alr)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei83Proton acceptor; specific for D-alanineUniRule annotation1
Binding sitei182SubstrateUniRule annotation1
Active sitei305Proton acceptor; specific for L-alanineUniRule annotation1
Binding sitei353Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
LigandPyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alr
Ordered Locus Names:RBE_1339
OrganismiRickettsia bellii (strain RML369-C)
Taxonomic identifieri336407 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group
Proteomesi
  • UP000001951 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002724041 – 410Alanine racemaseAdd BLAST410

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei83N6-(pyridoxal phosphate)lysineUniRule annotation1

Structurei

3D structure databases

ProteinModelPortaliQ1RGU4
SMRiQ1RGU4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 76RPE1 insertAdd BLAST49

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000031445
KOiK01775
OMAiWRGPILL
OrthoDBiPOG091H022F

Family and domain databases

Gene3Di2.40.37.101 hit
3.20.20.101 hit
HAMAPiMF_01201 Ala_racemase, 1 hit
InterProiView protein in InterPro
IPR000821 Ala_racemase
IPR009006 Ala_racemase/Decarboxylase_C
IPR011079 Ala_racemase_C
IPR001608 Ala_racemase_N
IPR029066 PLP-binding_barrel
IPR005728 Rickett_RPE
PfamiView protein in Pfam
PF00842 Ala_racemase_C, 1 hit
PF01168 Ala_racemase_N, 1 hit
PRINTSiPR00992 ALARACEMASE
SMARTiView protein in SMART
SM01005 Ala_racemase_C, 1 hit
SUPFAMiSSF50621 SSF50621, 1 hit
SSF51419 SSF51419, 1 hit
TIGRFAMsiTIGR00492 alr, 1 hit
TIGR01045 RPE1, 1 hit

Sequencei

Sequence statusi: Complete.

Q1RGU4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLCTLEINL SAIKANYRLL KNICENSVDF LHNVANKEEF AGNTSPRTAA
60 70 80 90 100
YTLVREDASL GSTPKLPLGA SYAKNLLVGA AVKANSYGLG AIEISKTLLE
110 120 130 140 150
ENCRYFFVAS SNEGISLRKA IGDEVNILIL NGVFEHDALE LIEYNLIPVL
160 170 180 190 200
NNLNQIKIWQ KFSNLKNQLL PCYLHFNTGI NRLGLNHNEI EQLINNRDLL
210 220 230 240 250
KGLNVEYIIS HLSASEDSDN PYNLEQLNKF KAYLEYFPNA KASLANSGGI
260 270 280 290 300
FLGKDYHFNL VRPGAALYGL NPLGSNKPNP MQNPVTLKAP IIHLQNLTYG
310 320 330 340 350
SRIGYNMTFT TKRDSLIATL PFGYADGFSR NFSNQGTVFI NSRNVPIIGR
360 370 380 390 400
ISMDLVNIDV TDLPPSDIFL GQEVEIIGNN CTPDKIADII GTIGYEILTS
410
LGNRYKRIYT
Length:410
Mass (Da):45,476
Last modified:May 16, 2006 - v1
Checksum:i91E898D4A3B5E1B6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000087 Genomic DNA Translation: ABE05420.1
RefSeqiWP_011477989.1, NC_007940.1

Genome annotation databases

EnsemblBacteriaiABE05420; ABE05420; RBE_1339
KEGGirbe:RBE_1339

Similar proteinsi

Entry informationi

Entry nameiALR_RICBR
AccessioniPrimary (citable) accession number: Q1RGU4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: May 16, 2006
Last modified: February 28, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome