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Q1RGP3

- SDHB_RICBR

UniProt

Q1RGP3 - SDHB_RICBR

Protein

Succinate dehydrogenase iron-sulfur subunit

Gene

sdhB

Organism
Rickettsia bellii (strain RML369-C)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (16 May 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Succinate + a quinone = fumarate + a quinol.

    Cofactori

    Binds 1 2Fe-2S cluster.
    Binds 1 3Fe-4S cluster.
    Binds 1 4Fe-4S cluster.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi80 – 801Iron-sulfur 1 (2Fe-2S)By similarity
    Metal bindingi85 – 851Iron-sulfur 1 (2Fe-2S)By similarity
    Metal bindingi100 – 1001Iron-sulfur 1 (2Fe-2S)By similarity
    Metal bindingi171 – 1711Iron-sulfur 2 (4Fe-4S)By similarity
    Metal bindingi174 – 1741Iron-sulfur 2 (4Fe-4S)By similarity
    Metal bindingi177 – 1771Iron-sulfur 2 (4Fe-4S)By similarity
    Metal bindingi181 – 1811Iron-sulfur 3 (3Fe-4S)By similarity
    Binding sitei186 – 1861Ubiquinone; shared with SdhD subunitBy similarity
    Metal bindingi228 – 2281Iron-sulfur 3 (3Fe-4S)By similarity
    Metal bindingi234 – 2341Iron-sulfur 3 (3Fe-4S)By similarity
    Metal bindingi238 – 2381Iron-sulfur 2 (4Fe-4S)By similarity

    GO - Molecular functioni

    1. 2 iron, 2 sulfur cluster binding Source: UniProtKB-KW
    2. 3 iron, 4 sulfur cluster binding Source: UniProtKB-KW
    3. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
    4. electron carrier activity Source: InterPro
    5. metal ion binding Source: UniProtKB-KW
    6. succinate dehydrogenase (ubiquinone) activity Source: UniProtKB-EC

    GO - Biological processi

    1. tricarboxylic acid cycle Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Transport, Tricarboxylic acid cycle

    Keywords - Ligandi

    2Fe-2S, 3Fe-4S, 4Fe-4S, Iron, Iron-sulfur, Metal-binding

    Enzyme and pathway databases

    BioCyciRBEL336407:GJCY-1430-MONOMER.
    RETL1328306-WGS:GSTH-3982-MONOMER.
    UniPathwayiUPA00223; UER01005.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Succinate dehydrogenase iron-sulfur subunit (EC:1.3.5.1)
    Gene namesi
    Name:sdhB
    Ordered Locus Names:RBE_1390
    OrganismiRickettsia bellii (strain RML369-C)
    Taxonomic identifieri336407 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group
    ProteomesiUP000001951: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 261261Succinate dehydrogenase iron-sulfur subunitPRO_0000280982Add
    BLAST

    Interactioni

    Subunit structurei

    Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur, cytochrome b-556, and a hydrophobic anchor protein.

    Protein-protein interaction databases

    STRINGi336407.RBE_1390.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1RGP3.
    SMRiQ1RGP3. Positions 25-256.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini28 – 119922Fe-2S ferredoxin-typePROSITE-ProRule annotationAdd
    BLAST
    Domaini161 – 191314Fe-4S ferredoxin-typePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 2Fe-2S ferredoxin-type domain.PROSITE-ProRule annotation
    Contains 1 4Fe-4S ferredoxin-type domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0479.
    HOGENOMiHOG000160590.
    KOiK00240.
    OMAiIMNCSRT.
    OrthoDBiEOG6CK7MG.

    Family and domain databases

    Gene3Di3.10.20.30. 1 hit.
    InterProiIPR001041. 2Fe-2S_ferredoxin-type.
    IPR006058. 2Fe2S_fd_BS.
    IPR017896. 4Fe4S_Fe-S-bd.
    IPR017900. 4Fe4S_Fe_S_CS.
    IPR012675. Beta-grasp_dom.
    IPR009051. Helical_ferredxn.
    IPR004489. Succ_DH/fum_Rdtase_Fe-S.
    IPR025192. Succ_DH/fum_Rdtase_N.
    [Graphical view]
    PfamiPF13085. Fer2_3. 1 hit.
    PF13183. Fer4_8. 1 hit.
    [Graphical view]
    SUPFAMiSSF46548. SSF46548. 1 hit.
    SSF54292. SSF54292. 1 hit.
    TIGRFAMsiTIGR00384. dhsB. 1 hit.
    PROSITEiPS00197. 2FE2S_FER_1. 1 hit.
    PS51085. 2FE2S_FER_2. 1 hit.
    PS00198. 4FE4S_FER_1. 1 hit.
    PS51379. 4FE4S_FER_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q1RGP3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAELRLPPNS VVKKGKEHKA KGDVSNLRKI KIYRYDPDLD ENPTIDSFEI    50
    DLSKTGPMVL DALIKIKNEI DSTVTFRRSC REGICGSCAM NIDGTNTLAC 100
    IKPIEEISGD IKIYPLPHMK VVKDLVPDMS HFYAQYESIE PWLKTDSPAP 150
    SNAERLQSIK DREKLDGLYE CILCACCSTS CPSYWWNGDK YLGPAILLQA 200
    YRWIADSRDD HTGERLEALE DPFKLYRCHT IMNCTKTCPK GLNPAKAISE 250
    IKGLIAERHG V 261
    Length:261
    Mass (Da):29,426
    Last modified:May 16, 2006 - v1
    Checksum:i841BDB90E88F7376
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000087 Genomic DNA. Translation: ABE05471.1.
    RefSeqiYP_538560.1. NC_007940.1.

    Genome annotation databases

    EnsemblBacteriaiABE05471; ABE05471; RBE_1390.
    GeneIDi3995557.
    KEGGirbe:RBE_1390.
    PATRICi17884444. VBIRicBel102610_1568.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000087 Genomic DNA. Translation: ABE05471.1 .
    RefSeqi YP_538560.1. NC_007940.1.

    3D structure databases

    ProteinModelPortali Q1RGP3.
    SMRi Q1RGP3. Positions 25-256.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 336407.RBE_1390.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABE05471 ; ABE05471 ; RBE_1390 .
    GeneIDi 3995557.
    KEGGi rbe:RBE_1390.
    PATRICi 17884444. VBIRicBel102610_1568.

    Phylogenomic databases

    eggNOGi COG0479.
    HOGENOMi HOG000160590.
    KOi K00240.
    OMAi IMNCSRT.
    OrthoDBi EOG6CK7MG.

    Enzyme and pathway databases

    UniPathwayi UPA00223 ; UER01005 .
    BioCyci RBEL336407:GJCY-1430-MONOMER.
    RETL1328306-WGS:GSTH-3982-MONOMER.

    Family and domain databases

    Gene3Di 3.10.20.30. 1 hit.
    InterProi IPR001041. 2Fe-2S_ferredoxin-type.
    IPR006058. 2Fe2S_fd_BS.
    IPR017896. 4Fe4S_Fe-S-bd.
    IPR017900. 4Fe4S_Fe_S_CS.
    IPR012675. Beta-grasp_dom.
    IPR009051. Helical_ferredxn.
    IPR004489. Succ_DH/fum_Rdtase_Fe-S.
    IPR025192. Succ_DH/fum_Rdtase_N.
    [Graphical view ]
    Pfami PF13085. Fer2_3. 1 hit.
    PF13183. Fer4_8. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46548. SSF46548. 1 hit.
    SSF54292. SSF54292. 1 hit.
    TIGRFAMsi TIGR00384. dhsB. 1 hit.
    PROSITEi PS00197. 2FE2S_FER_1. 1 hit.
    PS51085. 2FE2S_FER_2. 1 hit.
    PS00198. 4FE4S_FER_1. 1 hit.
    PS51379. 4FE4S_FER_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens."
      Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D.
      PLoS Genet. 2:733-744(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RML369-C.

    Entry informationi

    Entry nameiSDHB_RICBR
    AccessioniPrimary (citable) accession number: Q1RGP3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 20, 2007
    Last sequence update: May 16, 2006
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Rickettsia bellii strain RML369-C
      Rickettsia bellii (strain RML369-C): entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3