Q1RGP3 (DHSB_RICBR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Succinate dehydrogenase iron-sulfur subunit
EC=1.3.99.1

Gene names

Name:	sdhB
Ordered Locus Names:	RBE_1390

Organism

Rickettsia bellii (strain RML369-C) [Complete proteome] [HAMAP]

Taxonomic identifier

336407 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia

Protein attributes

Sequence length	261 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Succinate + acceptor = fumarate + reduced acceptor.
Cofactor	Binds 1 2Fe-2S cluster. Binds 1 3Fe-4S cluster. Binds 1 4Fe-4S cluster.
Pathway	Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (bacterial route): step 1/1.
Subunit structure	Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur, cytochrome b-556, and an hydrophobic anchor protein.
Sequence similarities	Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. Contains 1 2Fe-2S ferredoxin-type domain. Contains 1 4Fe-4S ferredoxin-type domain.

Ontologies

Keywords
Biological process	Electron transport Transport Tricarboxylic acid cycle
Ligand	2Fe-2S 3Fe-4S 4Fe-4S Iron Iron-sulfur Metal-binding
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW transport Inferred from electronic annotation. Source: UniProtKB-KW tricarboxylic acid cycle Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	2 iron, 2 sulfur cluster binding Inferred from electronic annotation. Source: UniProtKB-KW 3 iron, 4 sulfur cluster binding Inferred from electronic annotation. Source: UniProtKB-KW 4 iron, 4 sulfur cluster binding Inferred from electronic annotation. Source: UniProtKB-KW electron carrier activity Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW succinate dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 261	261	Succinate dehydrogenase iron-sulfur subunit		PRO_0000280982
Regions
	Domain	28 – 119	92	2Fe-2S ferredoxin-type
	Domain	161 – 191	31	4Fe-4S ferredoxin-type
Sites
	Metal binding	80	1	Iron-sulfur 1 (2Fe-2S) By similarity
	Metal binding	85	1	Iron-sulfur 1 (2Fe-2S) By similarity
	Metal binding	100	1	Iron-sulfur 1 (2Fe-2S) By similarity
	Metal binding	171	1	Iron-sulfur 2 (4Fe-4S) By similarity
	Metal binding	174	1	Iron-sulfur 2 (4Fe-4S) By similarity
	Metal binding	177	1	Iron-sulfur 2 (4Fe-4S) By similarity
	Metal binding	181	1	Iron-sulfur 3 (3Fe-4S) By similarity
	Metal binding	228	1	Iron-sulfur 3 (3Fe-4S) By similarity
	Metal binding	234	1	Iron-sulfur 3 (3Fe-4S) By similarity
	Metal binding	238	1	Iron-sulfur 2 (4Fe-4S) By similarity
	Binding site	186	1	Ubiquinone; shared with sdhD subunit By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q1RGP3 [UniParc]. Last modified May 16, 2006. Version 1. Checksum: 841BDB90E88F7376	FASTA	261	29,426
	10 20 30 40 50 60 MAELRLPPNS VVKKGKEHKA KGDVSNLRKI KIYRYDPDLD ENPTIDSFEI DLSKTGPMVL 70 80 90 100 110 120 DALIKIKNEI DSTVTFRRSC REGICGSCAM NIDGTNTLAC IKPIEEISGD IKIYPLPHMK 130 140 150 160 170 180 VVKDLVPDMS HFYAQYESIE PWLKTDSPAP SNAERLQSIK DREKLDGLYE CILCACCSTS 190 200 210 220 230 240 CPSYWWNGDK YLGPAILLQA YRWIADSRDD HTGERLEALE DPFKLYRCHT IMNCTKTCPK 250 260 GLNPAKAISE IKGLIAERHG V

References

[1]

"Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens." Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D. PLoS Genet. 2:733-744(2006) [PubMed: 16703114] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: RML369-C.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000087 Genomic DNA. Translation: ABE05471.1.
RefSeq	YP_538560.1. NC_007940.1.
3D structure databases
ProteinModelPortal	Q1RGP3.
SMR	Q1RGP3. Positions 25-256.
ModBase	Search...
Protein-protein interaction databases
STRING	Q1RGP3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3995557.
GenomeReviews	Gene locus RBE_1390 in contig CP000087_GR.
KEGG	rbe:RBE_1390.
PATRIC	17884444. VBIRicBel102610_1568.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0479.
HOGENOM	HBG616382.
OMA	IQVTQAI.
ProtClustDB	PRK05950.
Enzyme and pathway databases
BioCyc	RBEL336407:RBE_1390-MONOMER.
Family and domain databases
InterPro	IPR006058. 2Fe2S_fd_BS. IPR017896. 4Fe4S_Fe-S-bd. IPR017900. 4Fe4S_Fe_S_CS. IPR012675. Beta-grasp_ferredoxin-type. IPR001041. Ferredoxin. IPR012285. Fum_reductase_C. IPR009051. Helical_ferredxn. IPR004489. Succ_DH/fum_Rdtase_Fe-S. [Graphical view]
Gene3D	G3DSA:3.10.20.30. Ferredoxin_fold. 1 hit. G3DSA:1.10.1060.10. Fum_reductase_C. 1 hit.
KO	K00240.
SUPFAM	SSF54292. Ferredoxin. 1 hit. SSF46548. Helical_ferredxn. 1 hit.
TIGRFAMs	TIGR00384. DhsB. 1 hit.
PROSITE	PS00197. 2FE2S_FER_1. 1 hit. PS51085. 2FE2S_FER_2. 1 hit. PS00198. 4FE4S_FER_1. 1 hit. PS51379. 4FE4S_FER_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DHSB_RICBR

Accession

Primary (citable) accession number: Q1RGP3

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 20, 2007
Last sequence update:	May 16, 2006
Last modified:	January 25, 2012
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program