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Q1RGP3 (SDHB_RICBR) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Succinate dehydrogenase iron-sulfur subunit

EC=1.3.5.1
Gene names
Name:sdhB
Ordered Locus Names:RBE_1390
OrganismRickettsia bellii (strain RML369-C) [Complete proteome] [HAMAP]
Taxonomic identifier336407 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group

Protein attributes

Sequence length261 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Succinate + a quinone = fumarate + a quinol.

Cofactor

Binds 1 2Fe-2S cluster.

Binds 1 3Fe-4S cluster.

Binds 1 4Fe-4S cluster.

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (bacterial route): step 1/1.

Subunit structure

Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur, cytochrome b-556, and a hydrophobic anchor protein.

Sequence similarities

Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.

Contains 1 2Fe-2S ferredoxin-type domain.

Contains 1 4Fe-4S ferredoxin-type domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 261261Succinate dehydrogenase iron-sulfur subunit
PRO_0000280982

Regions

Domain28 – 119922Fe-2S ferredoxin-type
Domain161 – 191314Fe-4S ferredoxin-type

Sites

Metal binding801Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding851Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding1001Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding1711Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding1741Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding1771Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding1811Iron-sulfur 3 (3Fe-4S) By similarity
Metal binding2281Iron-sulfur 3 (3Fe-4S) By similarity
Metal binding2341Iron-sulfur 3 (3Fe-4S) By similarity
Metal binding2381Iron-sulfur 2 (4Fe-4S) By similarity
Binding site1861Ubiquinone; shared with SdhD subunit By similarity

Sequences

Sequence LengthMass (Da)Tools
Q1RGP3 [UniParc].

Last modified May 16, 2006. Version 1.
Checksum: 841BDB90E88F7376

FASTA26129,426
        10         20         30         40         50         60 
MAELRLPPNS VVKKGKEHKA KGDVSNLRKI KIYRYDPDLD ENPTIDSFEI DLSKTGPMVL 

        70         80         90        100        110        120 
DALIKIKNEI DSTVTFRRSC REGICGSCAM NIDGTNTLAC IKPIEEISGD IKIYPLPHMK 

       130        140        150        160        170        180 
VVKDLVPDMS HFYAQYESIE PWLKTDSPAP SNAERLQSIK DREKLDGLYE CILCACCSTS 

       190        200        210        220        230        240 
CPSYWWNGDK YLGPAILLQA YRWIADSRDD HTGERLEALE DPFKLYRCHT IMNCTKTCPK 

       250        260 
GLNPAKAISE IKGLIAERHG V 

« Hide

References

[1]"Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens."
Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D.
PLoS Genet. 2:733-744(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: RML369-C.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000087 Genomic DNA. Translation: ABE05471.1.
RefSeqYP_538560.1. NC_007940.1.

3D structure databases

ProteinModelPortalQ1RGP3.
SMRQ1RGP3. Positions 25-256.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING336407.RBE_1390.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABE05471; ABE05471; RBE_1390.
GeneID3995557.
KEGGrbe:RBE_1390.
PATRIC17884444. VBIRicBel102610_1568.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0479.
HOGENOMHOG000160590.
KOK00240.
OMAIMNCSRT.
OrthoDBEOG6CK7MG.

Enzyme and pathway databases

BioCycRBEL336407:GJCY-1430-MONOMER.
RETL1328306-WGS:GSTH-3982-MONOMER.
UniPathwayUPA00223; UER01005.

Family and domain databases

Gene3D3.10.20.30. 1 hit.
InterProIPR001041. 2Fe-2S_ferredoxin-type.
IPR006058. 2Fe2S_fd_BS.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR012675. Beta-grasp_dom.
IPR009051. Helical_ferredxn.
IPR004489. Succ_DH/fum_Rdtase_Fe-S.
IPR025192. Succ_DH/fum_Rdtase_N.
[Graphical view]
PfamPF13085. Fer2_3. 1 hit.
PF13183. Fer4_8. 1 hit.
[Graphical view]
SUPFAMSSF46548. SSF46548. 1 hit.
SSF54292. SSF54292. 1 hit.
TIGRFAMsTIGR00384. dhsB. 1 hit.
PROSITEPS00197. 2FE2S_FER_1. 1 hit.
PS51085. 2FE2S_FER_2. 1 hit.
PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSDHB_RICBR
AccessionPrimary (citable) accession number: Q1RGP3
Entry history
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: May 16, 2006
Last modified: July 9, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia bellii strain RML369-C

Rickettsia bellii (strain RML369-C): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways