Q1RGM9 (AK_RICBR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aspartokinase
EC=2.7.2.4

Alternative name(s):
Aspartate kinase

Gene names

Name:	lysC
Ordered Locus Names:	RBE_1404

Organism

Rickettsia bellii (strain RML369-C) [Complete proteome] [HAMAP]

Taxonomic identifier

336407 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia

Protein attributes

Sequence length	406 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + L-aspartate = ADP + 4-phospho-L-aspartate.
Pathway	Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4. Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 1/3. Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 1/5.
Sequence similarities	Belongs to the aspartokinase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Diaminopimelate biosynthesis Lysine biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	diaminopimelate biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW aspartate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 406	406	Aspartokinase		PRO_0000288718

Sequences

	Sequence		Length	Mass (Da)
	Q1RGM9 [UniParc]. Last modified May 16, 2006. Version 1. Checksum: 8A27CD8A2A864AC6	FASTA	406	44,682
	10 20 30 40 50 60 MALIIQKFGG TSVTTIDRIK KIIPIIKAEI AKNNQVIIVV SAMAGVTNQL VTLCNEVSSL 70 80 90 100 110 120 NKSSQLAEYD VALSSGEIVT ASLLALALQE ENINARSFLA WQLPILTDDN HSKALVESVD 130 140 150 160 170 180 TNLLNECLQQ NIIPIIAGFQ GINKHNRLAT LGRGGSDTTA ALIAAAMKAD RCDIYTDVEG 190 200 210 220 230 240 VFAADPRIIP KAKKIDEIDF SEMLELALSG AKVLHSRAAE IVMRYQIDMR ILSTFAPEAG 250 260 270 280 290 300 CTLITSKDKI MEKRIISGIT SNKNLLYITI ESSSLNFIQV ASIIAQNNNH IEVMQEIEPN 310 320 330 340 350 360 KRYSFITNLT DKNSLHILLT NLKNNNQISN FTFDTEIATV SIIGHGIKND LKLLEVILSK 370 380 390 400 LAKDNINVQM VQISEIKIIL LINDKQVEKT VLDLYDLLKI SETGHC

References

[1]

"Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens." Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D. PLoS Genet. 2:733-744(2006) [PubMed: 16703114] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: RML369-C.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000087 Genomic DNA. Translation: ABE05485.1.
RefSeq	YP_538574.1. NC_007940.1.
3D structure databases
ProteinModelPortal	Q1RGM9.
ModBase	Search...
Protein-protein interaction databases
STRING	Q1RGM9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3995472.
GenomeReviews	Gene locus RBE_1404 in contig CP000087_GR.
KEGG	rbe:RBE_1404.
PATRIC	17884474. VBIRicBel102610_1583.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0527.
HOGENOM	HBG724395.
OMA	NFTFDTE.
ProtClustDB	PRK06635.
Enzyme and pathway databases
BioCyc	RBEL336407:RBE_1404-MONOMER.
Family and domain databases
InterPro	IPR001048. Asp/Glu/Uridylate_kinase. IPR005260. Asp_kin_monofn. IPR001341. Asp_kinase_dom. IPR018042. Aspartate_kinase_CS. [Graphical view]
Gene3D	G3DSA:3.40.1160.10. Aa_kinase. 1 hit.
KO	K00928.
Pfam	PF00696. AA_kinase. 1 hit. [Graphical view]
PIRSF	PIRSF000726. Asp_kin. 1 hit.
SUPFAM	SSF53633. Aa_kinase. 1 hit.
TIGRFAMs	TIGR00657. Asp_kinases. 1 hit.
PROSITE	PS00324. ASPARTOKINASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AK_RICBR

Accession

Primary (citable) accession number: Q1RGM9

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 29, 2007
Last sequence update:	May 16, 2006
Last modified:	January 25, 2012
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program