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Q1RGK7 (TADA_RICBR) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
tRNA-specific adenosine deaminase

EC=3.5.4.33
Gene names
Name:tadA
Ordered Locus Names:RBE_1426
OrganismRickettsia bellii (strain RML369-C) [Complete proteome] [HAMAP]
Taxonomic identifier336407 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group

Protein attributes

Sequence length145 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) By similarity. HAMAP-Rule MF_00972

Catalytic activity

Adenine34 in tRNA + H2O = hypoxanthine34 in tRNA + NH3. HAMAP-Rule MF_00972

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP-Rule MF_00972

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00972

Sequence similarities

Belongs to the cytidine and deoxycytidylate deaminase family.

Contains 1 CMP/dCMP deaminase zinc-binding domain.

Sequence caution

The sequence ABE05507.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
   Biological processtRNA processing
   LigandMetal-binding
Zinc
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processtRNA wobble adenosine to inosine editing

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functiontRNA-specific adenosine-34 deaminase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 145145tRNA-specific adenosine deaminase HAMAP-Rule MF_00972
PRO_0000293135

Regions

Domain1 – 9696CMP/dCMP deaminase zinc-binding

Sites

Active site501Proton donor By similarity
Metal binding481Zinc; via pros nitrogen; catalytic By similarity
Metal binding781Zinc; catalytic By similarity
Metal binding811Zinc; catalytic By similarity

Sequences

Sequence LengthMass (Da)Tools
Q1RGK7 [UniParc].

Last modified July 10, 2007. Version 2.
Checksum: CE6A27A9CE98A90D

FASTA14516,358
        10         20         30         40         50         60 
MREALKQAEI AFSKNEVPVG AVIVDRENQK IISKSYNNTE EKNNALYHAE IIAINEACRI 

        70         80         90        100        110        120 
ISSKNLSDYD IYVTLEPCAM CAAAIAHSRL KRLFYGASDS KHGAVESNLR YFNSKACFHR 

       130        140 
PEIYSGIFAE DSALLMKGFF KKIRD 

« Hide

References

[1]"Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens."
Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D.
PLoS Genet. 2:733-744(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: RML369-C.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000087 Genomic DNA. Translation: ABE05507.1. Different initiation.
RefSeqYP_538596.1. NC_007940.1.

3D structure databases

ProteinModelPortalQ1RGK7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING336407.RBE_1426.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABE05507; ABE05507; RBE_1426.
GeneID3995858.
KEGGrbe:RBE_1426.
PATRIC17884528. VBIRicBel102610_1609.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0590.
HOGENOMHOG000085050.
KOK01485.
OrthoDBEOG64FKGZ.
ProtClustDBCLSK871102.

Enzyme and pathway databases

BioCycRBEL336407:GJCY-1467-MONOMER.

Family and domain databases

HAMAPMF_00972. tRNA_aden_deaminase.
InterProIPR016192. APOBEC/CMP_deaminase_Zn-bd.
IPR002125. CMP_dCMP_Zn-bd.
IPR016193. Cytidine_deaminase-like.
IPR028883. tRNA_aden_deaminase.
[Graphical view]
PfamPF00383. dCMP_cyt_deam_1. 1 hit.
[Graphical view]
SUPFAMSSF53927. SSF53927. 1 hit.
PROSITEPS00903. CYT_DCMP_DEAMINASES. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTADA_RICBR
AccessionPrimary (citable) accession number: Q1RGK7
Entry history
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 10, 2007
Last modified: April 16, 2014
This is version 49 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia bellii strain RML369-C

Rickettsia bellii (strain RML369-C): entries and gene names