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Q1RGK7

- TADA_RICBR

UniProt

Q1RGK7 - TADA_RICBR

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Protein

tRNA-specific adenosine deaminase

Gene

tadA

Organism
Rickettsia bellii (strain RML369-C)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).UniRule annotation

Catalytic activityi

Adenine(34) in tRNA + H2O = hypoxanthine(34) in tRNA + NH3.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi48 – 481Zinc; via pros nitrogen; catalyticUniRule annotation
Active sitei50 – 501Proton donorUniRule annotation
Metal bindingi78 – 781Zinc; catalyticUniRule annotation
Metal bindingi81 – 811Zinc; catalyticUniRule annotation

GO - Molecular functioni

  1. tRNA-specific adenosine-34 deaminase activity Source: UniProtKB-HAMAP
  2. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. tRNA wobble adenosine to inosine editing Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciRBEL336407:GJCY-1467-MONOMER.
RETL1328306-WGS:GSTH-847-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA-specific adenosine deaminaseUniRule annotation (EC:3.5.4.33UniRule annotation)
Gene namesi
Name:tadAUniRule annotation
Ordered Locus Names:RBE_1426
OrganismiRickettsia bellii (strain RML369-C)
Taxonomic identifieri336407 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group
ProteomesiUP000001951: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 145145tRNA-specific adenosine deaminasePRO_0000293135Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi336407.RBE_1426.

Structurei

3D structure databases

ProteinModelPortaliQ1RGK7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 9696CMP/dCMP deaminase zinc-bindingUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the cytidine and deoxycytidylate deaminase family.UniRule annotation
Contains 1 CMP/dCMP deaminase zinc-binding domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG0590.
HOGENOMiHOG000085050.
KOiK01485.
OrthoDBiEOG64FKGZ.

Family and domain databases

HAMAPiMF_00972. tRNA_aden_deaminase.
InterProiIPR016192. APOBEC/CMP_deaminase_Zn-bd.
IPR002125. CMP_dCMP_Zn-bd.
IPR016193. Cytidine_deaminase-like.
IPR028883. tRNA_aden_deaminase.
[Graphical view]
PfamiPF00383. dCMP_cyt_deam_1. 1 hit.
[Graphical view]
SUPFAMiSSF53927. SSF53927. 1 hit.
PROSITEiPS00903. CYT_DCMP_DEAMINASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1RGK7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MREALKQAEI AFSKNEVPVG AVIVDRENQK IISKSYNNTE EKNNALYHAE
60 70 80 90 100
IIAINEACRI ISSKNLSDYD IYVTLEPCAM CAAAIAHSRL KRLFYGASDS
110 120 130 140
KHGAVESNLR YFNSKACFHR PEIYSGIFAE DSALLMKGFF KKIRD
Length:145
Mass (Da):16,358
Last modified:July 10, 2007 - v2
Checksum:iCE6A27A9CE98A90D
GO

Sequence cautioni

The sequence ABE05507.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000087 Genomic DNA. Translation: ABE05507.1. Different initiation.
RefSeqiYP_538596.1. NC_007940.1.

Genome annotation databases

EnsemblBacteriaiABE05507; ABE05507; RBE_1426.
GeneIDi3995858.
KEGGirbe:RBE_1426.
PATRICi17884528. VBIRicBel102610_1609.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000087 Genomic DNA. Translation: ABE05507.1 . Different initiation.
RefSeqi YP_538596.1. NC_007940.1.

3D structure databases

ProteinModelPortali Q1RGK7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 336407.RBE_1426.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABE05507 ; ABE05507 ; RBE_1426 .
GeneIDi 3995858.
KEGGi rbe:RBE_1426.
PATRICi 17884528. VBIRicBel102610_1609.

Phylogenomic databases

eggNOGi COG0590.
HOGENOMi HOG000085050.
KOi K01485.
OrthoDBi EOG64FKGZ.

Enzyme and pathway databases

BioCyci RBEL336407:GJCY-1467-MONOMER.
RETL1328306-WGS:GSTH-847-MONOMER.

Family and domain databases

HAMAPi MF_00972. tRNA_aden_deaminase.
InterProi IPR016192. APOBEC/CMP_deaminase_Zn-bd.
IPR002125. CMP_dCMP_Zn-bd.
IPR016193. Cytidine_deaminase-like.
IPR028883. tRNA_aden_deaminase.
[Graphical view ]
Pfami PF00383. dCMP_cyt_deam_1. 1 hit.
[Graphical view ]
SUPFAMi SSF53927. SSF53927. 1 hit.
PROSITEi PS00903. CYT_DCMP_DEAMINASES. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens."
    Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D.
    PLoS Genet. 2:733-744(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RML369-C.

Entry informationi

Entry nameiTADA_RICBR
AccessioniPrimary (citable) accession number: Q1RGK7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 10, 2007
Last modified: November 26, 2014
This is version 53 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia bellii strain RML369-C
    Rickettsia bellii (strain RML369-C): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3