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Protein

Chaperone SurA

Gene

surA

Organism
Escherichia coli (strain UTI89 / UPEC)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation.UniRule annotation

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone, Isomerase, Rotamase

Names & Taxonomyi

Protein namesi
Recommended name:
Chaperone SurAUniRule annotation
Alternative name(s):
Peptidyl-prolyl cis-trans isomerase SurAUniRule annotation (EC:5.2.1.8UniRule annotation)
Short name:
PPIase SurAUniRule annotation
Rotamase SurAUniRule annotation
Gene namesi
Name:surAUniRule annotation
Ordered Locus Names:UTI89_C0060
OrganismiEscherichia coli (strain UTI89 / UPEC)
Taxonomic identifieri364106 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000001952 Componenti: Chromosome

Subcellular locationi

  • Periplasm UniRule annotation

  • Note: Is capable of associating with the outer membrane.UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20UniRule annotationAdd BLAST20
ChainiPRO_000027001421 – 428Chaperone SurAAdd BLAST408

Structurei

3D structure databases

ProteinModelPortaliQ1RGE4.
SMRiQ1RGE4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini171 – 272PpiC 1UniRule annotationAdd BLAST102
Domaini282 – 382PpiC 2UniRule annotationAdd BLAST101

Domaini

The PPIase activity resides only in the second parvulin domain. The N-terminal region and the C-terminal tail are necessary and sufficient for the chaperone activity of SurA. The PPIase activity is dispensable for SurA to function as a chaperone. The N-terminal region and the C-terminal tail are also required for porin recognition.UniRule annotation

Sequence similaritiesi

Contains 2 PpiC domains.UniRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

HOGENOMiHOG000264337.
KOiK03771.
OMAiFGVHLIQ.

Family and domain databases

Gene3Di1.10.3120.10. 1 hit.
HAMAPiMF_01183. Chaperone_SurA. 1 hit.
InterProiIPR000297. PPIase_PpiC.
IPR023058. PPIase_PpiC_CS.
IPR023034. PPIase_SurA.
IPR015391. SurA_N.
IPR008880. Trigger_fac_C.
IPR027304. Trigger_fact/SurA_dom.
[Graphical view]
PfamiPF00639. Rotamase. 1 hit.
PF09312. SurA_N. 1 hit.
[Graphical view]
SUPFAMiSSF109998. SSF109998. 1 hit.
PROSITEiPS01096. PPIC_PPIASE_1. 2 hits.
PS50198. PPIC_PPIASE_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q1RGE4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNWKTLLLG IAMIANTSFA APQVVDKVAA VVNNGVVLES DVDGLMQSVK
60 70 80 90 100
LNAAQARQQL PDDATLRHQI MERLIMDQII LQMGQKMGVK ISDEQLDQAI
110 120 130 140 150
ANIAKQNNMT LDQMRSRLAY DGLNYNTYRN QIRKEMIISE VRNNEVRRRI
160 170 180 190 200
TILPQEVESL AQQVGNQNDA STELNLSHIL IPLPENPTSD QVNEAESQAR
210 220 230 240 250
AIVDQARNGA DFGKLAIAHS ADQQALNGGQ MGWGRIQELP GIFAQALSTA
260 270 280 290 300
KKGDIVGPIR SGVGFHILKV NDLRGESKNI SVTEVHARHI LLKPSPIMTD
310 320 330 340 350
EQARVKLEQI AADIKSGKTT FAAAAKEFSQ DPGSANQGGD LGWATPDIFD
360 370 380 390 400
PAFRDALTRL NKGQMSAPVH SSFGWHLIEL LDTRNVDKTD AAQKDRAYRM
410 420
LMNRKFSEEA ASWMQEQRAS AYVKILSN
Length:428
Mass (Da):47,284
Last modified:May 16, 2006 - v1
Checksum:i25F6AD4B903CBD8E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000243 Genomic DNA. Translation: ABE05570.1.
RefSeqiWP_000800457.1. NC_007946.1.

Genome annotation databases

EnsemblBacteriaiABE05570; ABE05570; UTI89_C0060.
KEGGieci:UTI89_C0060.
PATRICi18449821. VBIEscCol42261_0192.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000243 Genomic DNA. Translation: ABE05570.1.
RefSeqiWP_000800457.1. NC_007946.1.

3D structure databases

ProteinModelPortaliQ1RGE4.
SMRiQ1RGE4.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABE05570; ABE05570; UTI89_C0060.
KEGGieci:UTI89_C0060.
PATRICi18449821. VBIEscCol42261_0192.

Phylogenomic databases

HOGENOMiHOG000264337.
KOiK03771.
OMAiFGVHLIQ.

Family and domain databases

Gene3Di1.10.3120.10. 1 hit.
HAMAPiMF_01183. Chaperone_SurA. 1 hit.
InterProiIPR000297. PPIase_PpiC.
IPR023058. PPIase_PpiC_CS.
IPR023034. PPIase_SurA.
IPR015391. SurA_N.
IPR008880. Trigger_fac_C.
IPR027304. Trigger_fact/SurA_dom.
[Graphical view]
PfamiPF00639. Rotamase. 1 hit.
PF09312. SurA_N. 1 hit.
[Graphical view]
SUPFAMiSSF109998. SSF109998. 1 hit.
PROSITEiPS01096. PPIC_PPIASE_1. 2 hits.
PS50198. PPIC_PPIASE_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSURA_ECOUT
AccessioniPrimary (citable) accession number: Q1RGE4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: May 16, 2006
Last modified: November 30, 2016
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.