ID   ARAA_ECOUT              Reviewed;         500 AA.
AC   Q1RGD7;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-MAY-2006, sequence version 1.
DT   16-JUN-2009, entry version 21.
DE   RecName: Full=L-arabinose isomerase;
DE            EC=5.3.1.4;
GN   Name=araA; OrderedLocusNames=UTI89_C0067;
OS   Escherichia coli (strain UTI89 / UPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=364106;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16585510; DOI=10.1073/pnas.0600938103;
RA   Chen S.L., Hung C.-S., Xu J., Reigstad C.S., Magrini V., Sabo A.,
RA   Blasiar D., Bieri T., Meyer R.R., Ozersky P., Armstrong J.R.,
RA   Fulton R.S., Latreille J.P., Spieth J., Hooton T.M., Mardis E.R.,
RA   Hultgren S.J., Gordon J.I.;
RT   "Identification of genes subject to positive selection in
RT   uropathogenic strains of Escherichia coli: a comparative genomics
RT   approach.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:5977-5982(2006).
CC   -!- FUNCTION: Catalyzes the conversion of L-arabinose to L-ribulose
CC       (By similarity).
CC   -!- CATALYTIC ACTIVITY: L-arabinose = L-ribulose.
CC   -!- COFACTOR: Binds 1 manganese ion per subunit (By similarity).
CC   -!- PATHWAY: Carbohydrate degradation; L-arabinose degradation via L-
CC       ribulose; D-xylulose 5-phosphate from L-arabinose (bacteria
CC       route): step 1/3.
CC   -!- SUBUNIT: Homohexamer (By similarity).
CC   -!- SIMILARITY: Belongs to the arabinose isomerase family.
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DR   EMBL; CP000243; ABE05577.1; -; Genomic_DNA.
DR   RefSeq; YP_539108.1; -.
DR   SMR; Q1RGD7; 1-498.
DR   GeneID; 3993628; -.
DR   GenomeReviews; CP000243_GR; UTI89_C0067.
DR   KEGG; eci:UTI89_C0067; -.
DR   HOGENOM; Q1RGD7; -.
DR   OMA; Q1RGD7; EVCPTIA.
DR   BioCyc; ECOL364106:UTI89_C0067-MON; -.
DR   GO; GO:0008733; F:L-arabinose isomerase activity; IEA:HAMAP.
DR   GO; GO:0030145; F:manganese ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0019568; P:arabinose catabolic process; IEA:HAMAP.
DR   HAMAP; MF_00519; -; 1.
DR   InterPro; IPR003762; Lara_isomerase.
DR   Pfam; PF02610; Arabinose_Isome; 1.
DR   PIRSF; PIRSF001478; L-ara_isomerase; 1.
DR   ProDom; PD018364; Lara_isomerase; 1.
PE   3: Inferred from homology;
KW   Arabinose catabolism; Carbohydrate metabolism; Complete proteome;
KW   Isomerase; Manganese; Metal-binding.
FT   CHAIN         1    500       L-arabinose isomerase.
FT                                /FTId=PRO_0000259337.
FT   METAL       306    306       Manganese (By similarity).
FT   METAL       333    333       Manganese (By similarity).
FT   METAL       350    350       Manganese (By similarity).
FT   METAL       450    450       Manganese (By similarity).
SQ   SEQUENCE   500 AA;  56103 MW;  E1B1B9F2FACF1FBD CRC64;
     MTIFDNYEVW FVIGSQHLYG PETLRQVTQH AEHVVNALNT EAKLPCKLVL KPLGTTPDEI
     TAICRDANYD DRCAGLVVWL HTFSPAKMWI NGLTMLNKPL LQFHTQFNAA LPWDSIDMDF
     MNLNQTAHGG REFGFIGARM RQQHAVVTGH WQDKQAHERI GSWMRQAVSK QDTRHLKVCR
     FGDNMREVAV TDGDKVAAQI KFGFSVNTWA VGDLVQVVNS ISDGDVNALV DEYESCYTMT
     PATQIHGEKR QNVLEAARIE LGMKRFLEQG GFHAFTTTFE DLHGLKQLPG LAVQRLMQQG
     YGFAGEGDWK TAALLRIMKV MSTGLQGGTS FMEDYTYHFE KGNDLVLGSH MLEVCPSIAV
     EEKPILDVQH LGIGGKDDPA RLIFNTQTGP AIVASLIDLG DRYRLLVNCI DTVKTPHSLP
     KLPVANALWK AQPDLPTASE AWILAGGAHH TVFSHALNLN DMRQFAEMHD IEITVIDNDT
     RLPAFKDALR WNEVYYGFRR
//