ID   GAL1_ECOUT              Reviewed;         382 AA.
AC   Q1REH4;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-MAY-2006, sequence version 1.
DT   16-JUN-2009, entry version 21.
DE   RecName: Full=Galactokinase;
DE            EC=2.7.1.6;
DE   AltName: Full=Galactose kinase;
GN   Name=galK; OrderedLocusNames=UTI89_C0754;
OS   Escherichia coli (strain UTI89 / UPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=364106;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16585510; DOI=10.1073/pnas.0600938103;
RA   Chen S.L., Hung C.-S., Xu J., Reigstad C.S., Magrini V., Sabo A.,
RA   Blasiar D., Bieri T., Meyer R.R., Ozersky P., Armstrong J.R.,
RA   Fulton R.S., Latreille J.P., Spieth J., Hooton T.M., Mardis E.R.,
RA   Hultgren S.J., Gordon J.I.;
RT   "Identification of genes subject to positive selection in
RT   uropathogenic strains of Escherichia coli: a comparative genomics
RT   approach.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:5977-5982(2006).
CC   -!- CATALYTIC ACTIVITY: ATP + D-galactose = ADP + alpha-D-galactose 1-
CC       phosphate.
CC   -!- PATHWAY: Carbohydrate metabolism; galactose metabolism.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (Potential).
CC   -!- SIMILARITY: Belongs to the GHMP kinase family. GalK subfamily.
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DR   EMBL; CP000243; ABE06240.1; -; Genomic_DNA.
DR   RefSeq; YP_539771.1; -.
DR   GeneID; 3991531; -.
DR   GenomeReviews; CP000243_GR; UTI89_C0754.
DR   KEGG; eci:UTI89_C0754; -.
DR   HOGENOM; Q1REH4; -.
DR   OMA; Q1REH4; YNDGFVM.
DR   BioCyc; ECOL364106:UTI89_C0754-MON; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:HAMAP.
DR   GO; GO:0004335; F:galactokinase activity; IEA:HAMAP.
DR   GO; GO:0046835; P:carbohydrate phosphorylation; IEA:InterPro.
DR   GO; GO:0006012; P:galactose metabolic process; IEA:HAMAP.
DR   HAMAP; MF_00246; -; 1.
DR   InterPro; IPR000705; Galactokinase.
DR   InterPro; IPR019741; Galactokinase_CS.
DR   InterPro; IPR019539; GalKase_gal_bd.
DR   InterPro; IPR006204; GHMP_kinase.
DR   InterPro; IPR013750; GHMP_kinase_C.
DR   InterPro; IPR006203; GHMP_knse_ATP_bd_CS.
DR   InterPro; IPR006206; Mev_galkinase.
DR   InterPro; IPR014721; Ribosomal_S5_D2-type_fold.
DR   Gene3D; G3DSA:3.30.230.10; Ribosomal_S5_D2-type_fold; 1.
DR   Pfam; PF10509; GalKase_gal_bdg; 1.
DR   Pfam; PF08544; GHMP_kinases_C; 1.
DR   Pfam; PF00288; GHMP_kinases_N; 1.
DR   PIRSF; PIRSF000530; Galactokinase; 1.
DR   PRINTS; PR00473; GALCTOKINASE.
DR   PRINTS; PR00959; MEVGALKINASE.
DR   TIGRFAMs; TIGR00131; gal_kin; 1.
DR   PROSITE; PS00106; GALACTOKINASE; 1.
DR   PROSITE; PS00627; GHMP_KINASES_ATP; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Carbohydrate metabolism; Complete proteome; Cytoplasm;
KW   Galactose metabolism; Kinase; Nucleotide-binding; Transferase.
FT   CHAIN         1    382       Galactokinase.
FT                                /FTId=PRO_1000005750.
FT   NP_BIND     122    132       ATP (Potential).
SQ   SEQUENCE   382 AA;  41476 MW;  BE4B6CE6FC48F9A8 CRC64;
     MSLKEKTQSL FANAFGYPAT HTIQAPGRVN LIGEHTDYND GFVLPCAIDY QTVISCAPRD
     DRKVRVMAAD YENQLDEFSL DAPIVAHENY QWANYVRGVV KHLQLRNNSF GGVDMVISGN
     VPQGAGLSSS ASLEVAVGTV LQQLYHLPLD GAQIALNGQE AENQFVGCNC GIMDQLISAL
     GKKDHALLID CRSLGTKAVS MPKGVAVVII NSNFKRTLVG SEYNTRREQC ETGARFFQQP
     ALRDVTIEEF NAVAHELDPI VAKRVRHILT ENARTVEAAS ALEQGDLKRM GELMAESHAS
     MRDDFEITVP QIDTLVEIVK AVIGDKGGVR MTGGGFGGCI VALFPEELVP AVQQAVAEQY
     EAKTGIKETF YVCKPSQGAG QC
//