ID   NAGK_ECOUT              Reviewed;         303 AA.
AC   Q1RD35;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-MAY-2006, sequence version 1.
DT   16-JUN-2009, entry version 22.
DE   RecName: Full=N-acetyl-D-glucosamine kinase;
DE            EC=2.7.1.59;
DE   AltName: Full=GlcNAc kinase;
GN   Name=nagK; OrderedLocusNames=UTI89_C1247;
OS   Escherichia coli (strain UTI89 / UPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=364106;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16585510; DOI=10.1073/pnas.0600938103;
RA   Chen S.L., Hung C.-S., Xu J., Reigstad C.S., Magrini V., Sabo A.,
RA   Blasiar D., Bieri T., Meyer R.R., Ozersky P., Armstrong J.R.,
RA   Fulton R.S., Latreille J.P., Spieth J., Hooton T.M., Mardis E.R.,
RA   Hultgren S.J., Gordon J.I.;
RT   "Identification of genes subject to positive selection in
RT   uropathogenic strains of Escherichia coli: a comparative genomics
RT   approach.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:5977-5982(2006).
CC   -!- FUNCTION: Catalyzes the phosphorylation of N-acetyl-D-glucosamine
CC       (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P
CC       (By similarity).
CC   -!- CATALYTIC ACTIVITY: ATP + N-acetyl-D-glucosamine = ADP + N-acetyl-
CC       D-glucosamine 6-phosphate.
CC   -!- PATHWAY: Cell wall biogenesis; peptidoglycan recycling.
CC   -!- SIMILARITY: Belongs to the ROK (nagC/xylR) family. NagK subfamily.
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DR   EMBL; CP000243; ABE06729.1; -; Genomic_DNA.
DR   RefSeq; YP_540260.1; -.
DR   SMR; Q1RD35; 1-303.
DR   GeneID; 3992705; -.
DR   GenomeReviews; CP000243_GR; UTI89_C1247.
DR   KEGG; eci:UTI89_C1247; -.
DR   HOGENOM; Q1RD35; -.
DR   OMA; Q1RD35; HVERFME.
DR   BioCyc; ECOL364106:UTI89_C1247-MON; -.
DR   GO; GO:0005524; F:ATP binding; IEA:HAMAP.
DR   GO; GO:0045127; F:N-acetylglucosamine kinase activity; IEA:HAMAP.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006044; P:N-acetylglucosamine metabolic process; IEA:HAMAP.
DR   GO; GO:0009254; P:peptidoglycan turnover; IEA:HAMAP.
DR   HAMAP; MF_01271; -; 1.
DR   InterPro; IPR000600; ROK.
DR   Pfam; PF00480; ROK; 1.
DR   PROSITE; PS01125; ROK; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Carbohydrate metabolism; Complete proteome; Kinase;
KW   Metal-binding; Nucleotide-binding; Transferase; Zinc.
FT   CHAIN         1    303       N-acetyl-D-glucosamine kinase.
FT                                /FTId=PRO_0000270104.
FT   NP_BIND       4     11       ATP (Potential).
FT   NP_BIND     133    140       ATP (Potential).
FT   METAL       157    157       Zinc (By similarity).
FT   METAL       177    177       Zinc (By similarity).
FT   METAL       179    179       Zinc (By similarity).
FT   METAL       184    184       Zinc (By similarity).
SQ   SEQUENCE   303 AA;  33085 MW;  0757E639EB22510C CRC64;
     MYYGFDIGGT KIALGVFDSG RQLQWEKRVP TPRDSYDAFL DAVCELVAEA DRRFGCKGSV
     GIGIPGMPET EDGTLYAANV PAASGKPLRA DLSARLDRDV RLDNDANCFA LSEAWDDEFT
     QYPLVMGLIL GTGVGGGLIF NGKPITGKSY ITGEFGHMRL PVDALTMMGL DFPLRRCGCG
     QHGCIENYLS GRGFAWLYQH YYHQPLQAPE IIALYDQGDE QARAHVERYL DLLAVCLGNI
     LTIVDPDLVV IGGGLSNFPA ITTQLAERLP RHLLPVARVP RIERARHGDA GGMRGAAFLH
     LTD
//