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Protein

Periplasmic trehalase

Gene

treA

Organism
Escherichia coli (strain UTI89 / UPEC)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system.UniRule annotation

Catalytic activityi

Alpha,alpha-trehalose + H2O = beta-D-glucose + alpha-D-glucose.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei152SubstrateUniRule annotation1
Binding sitei196SubstrateUniRule annotation1
Binding sitei310Substrate; via carbonyl oxygenUniRule annotation1
Active sitei312Proton donor/acceptorUniRule annotation1
Active sitei496Proton donor/acceptorUniRule annotation1
Binding sitei511SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Protein family/group databases

CAZyiGH37. Glycoside Hydrolase Family 37.

Names & Taxonomyi

Protein namesi
Recommended name:
Periplasmic trehalaseUniRule annotation (EC:3.2.1.28UniRule annotation)
Alternative name(s):
Alpha,alpha-trehalaseUniRule annotation
Alpha,alpha-trehalose glucohydrolaseUniRule annotation
Gene namesi
Name:treAUniRule annotation
Ordered Locus Names:UTI89_C1389
OrganismiEscherichia coli (strain UTI89 / UPEC)
Taxonomic identifieri364106 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000001952 Componenti: Chromosome

Subcellular locationi

  • Periplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30UniRule annotationAdd BLAST30
ChainiPRO_100006445431 – 565Periplasmic trehalaseAdd BLAST535

Interactioni

Subunit structurei

Monomer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ1RCP3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni159 – 160Substrate bindingUniRule annotation2
Regioni205 – 207Substrate bindingUniRule annotation3
Regioni277 – 279Substrate bindingUniRule annotation3

Sequence similaritiesi

Belongs to the glycosyl hydrolase 37 family.UniRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000215464.
KOiK01194.
OMAiWAGQLHQ.

Family and domain databases

HAMAPiMF_01060. Peripl_trehalase. 1 hit.
InterProiIPR008928. 6-hairpin_glycosidase-like.
IPR001661. Glyco_hydro_37.
IPR018232. Glyco_hydro_37_CS.
IPR023720. Trehalase_periplasmic.
[Graphical view]
PANTHERiPTHR23403. PTHR23403. 1 hit.
PfamiPF01204. Trehalase. 1 hit.
[Graphical view]
PRINTSiPR00744. GLHYDRLASE37.
SUPFAMiSSF48208. SSF48208. 1 hit.
PROSITEiPS00927. TREHALASE_1. 1 hit.
PS00928. TREHALASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q1RCP3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSPAPSRPQ KMALIPACIF LCFAALSVQA EETSVTPQPP DILLGPLFND
60 70 80 90 100
VQNAKLFPDQ KTFADAVPNS DPLMILADYR MQQNQSGFDL RHFVNVNFTL
110 120 130 140 150
PKEGEKYVPP EGQSLREHID GLWPVLTRST ENTEKWDSLL PLPKPYVVPG
160 170 180 190 200
GRFREVYYWD SYFTMLGLAE SGHWDKVADM VANFAHEIDN YGHIPNGNRS
210 220 230 240 250
YYLSRSQPPF FALMVELLAQ HEGDAALKQY LPQMQKEYAY WMDGVENLQA
260 270 280 290 300
GQQEKRVVKL QDGTLLNRYW DDRDTPRPES WVEDIATAKS NPNRPATEIY
310 320 330 340 350
RDLRSAAASG WDFSSRWMDN PQQLNTLRTT SIVPVDLNSL MFKMEKILAR
360 370 380 390 400
ASKAIGDNAM ANQYETLANA RQKGIEKYLW NDQQGWYADY DLKSHKVRNQ
410 420 430 440 450
LTAAALFPLY VNAAAKDRAS KMATATKTHL LQPGGLNTTS VKSGQQWDAP
460 470 480 490 500
NGWAPLQWVA TEGLQNYGQK EVAMDISWHF LTNVQHTYDR EKKLVEKYDV
510 520 530 540 550
STTGTGGGGG EYPLQDGFGW TNGVTLKMLD LICPKEQPCD NVPATRPLSE
560
STTQPLKQKE AEPTP
Length:565
Mass (Da):63,766
Last modified:May 16, 2006 - v1
Checksum:i627B94A895C87446
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000243 Genomic DNA. Translation: ABE06871.1.
RefSeqiWP_000841739.1. NC_007946.1.

Genome annotation databases

EnsemblBacteriaiABE06871; ABE06871; UTI89_C1389.
KEGGieci:UTI89_C1389.
PATRICi18452379. VBIEscCol42261_1443.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000243 Genomic DNA. Translation: ABE06871.1.
RefSeqiWP_000841739.1. NC_007946.1.

3D structure databases

ProteinModelPortaliQ1RCP3.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiGH37. Glycoside Hydrolase Family 37.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABE06871; ABE06871; UTI89_C1389.
KEGGieci:UTI89_C1389.
PATRICi18452379. VBIEscCol42261_1443.

Phylogenomic databases

HOGENOMiHOG000215464.
KOiK01194.
OMAiWAGQLHQ.

Family and domain databases

HAMAPiMF_01060. Peripl_trehalase. 1 hit.
InterProiIPR008928. 6-hairpin_glycosidase-like.
IPR001661. Glyco_hydro_37.
IPR018232. Glyco_hydro_37_CS.
IPR023720. Trehalase_periplasmic.
[Graphical view]
PANTHERiPTHR23403. PTHR23403. 1 hit.
PfamiPF01204. Trehalase. 1 hit.
[Graphical view]
PRINTSiPR00744. GLHYDRLASE37.
SUPFAMiSSF48208. SSF48208. 1 hit.
PROSITEiPS00927. TREHALASE_1. 1 hit.
PS00928. TREHALASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTREA_ECOUT
AccessioniPrimary (citable) accession number: Q1RCP3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 16, 2006
Last modified: November 2, 2016
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.