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Protein

Trans-aconitate 2-methyltransferase

Gene

tam

Organism
Escherichia coli (strain UTI89 / UPEC)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + trans-aconitate = S-adenosyl-L-homocysteine + (E)-3-(methoxycarbonyl)pent-2-enedioate.UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciECOL364106:GHPQ-1725-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Trans-aconitate 2-methyltransferaseUniRule annotation (EC:2.1.1.144UniRule annotation)
Gene namesi
Name:tamUniRule annotation
Ordered Locus Names:UTI89_C1738
OrganismiEscherichia coli (strain UTI89 / UPEC)
Taxonomic identifieri364106 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000001952 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 252252Trans-aconitate 2-methyltransferasePRO_1000056559Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ1RBP8.
SMRiQ1RBP8. Positions 6-250.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the methyltransferase superfamily. Tam family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000125295.
KOiK00598.
OMAiARVDVWR.
OrthoDBiEOG6716PV.

Family and domain databases

Gene3Di1.10.150.290. 1 hit.
3.40.50.150. 1 hit.
HAMAPiMF_00560. Tran_acon_Me_trans.
InterProiIPR029063. SAM-dependent_MTases.
IPR023506. Trans-aconitate_MeTrfase.
IPR023149. Trans_acon_MeTrfase_C.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1RBP8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDWNPSLYL HFAAERSRPA VELLARVSLE NIEYIADLGC GPGNSTALLH
60 70 80 90 100
QRWPAARITG IDSSPAMIAE ARSALPDCLF VEADIRNWQP EQALDLIFAN
110 120 130 140 150
ASLQWLPDHY ELFPHLVSLL SPLGVLAVQM PDNWLEPTHV LMREVAWEQN
160 170 180 190 200
YPDRGREPLA GVHAYYDILS EAGCEVDIWR TTYYHQMPSH QAIIDWVTAT
210 220 230 240 250
GLRPWLQDLT ESEQQHFLTR YHQMLEEQYP LQENGQILLA FPRLFIVARR

TE
Length:252
Mass (Da):28,957
Last modified:May 16, 2006 - v1
Checksum:i61D1CF3939D19869
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000243 Genomic DNA. Translation: ABE07216.1.
RefSeqiWP_001286588.1. NC_007946.1.

Genome annotation databases

EnsemblBacteriaiABE07216; ABE07216; UTI89_C1738.
KEGGieci:UTI89_C1738.
PATRICi18453066. VBIEscCol42261_1782.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000243 Genomic DNA. Translation: ABE07216.1.
RefSeqiWP_001286588.1. NC_007946.1.

3D structure databases

ProteinModelPortaliQ1RBP8.
SMRiQ1RBP8. Positions 6-250.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABE07216; ABE07216; UTI89_C1738.
KEGGieci:UTI89_C1738.
PATRICi18453066. VBIEscCol42261_1782.

Phylogenomic databases

HOGENOMiHOG000125295.
KOiK00598.
OMAiARVDVWR.
OrthoDBiEOG6716PV.

Enzyme and pathway databases

BioCyciECOL364106:GHPQ-1725-MONOMER.

Family and domain databases

Gene3Di1.10.150.290. 1 hit.
3.40.50.150. 1 hit.
HAMAPiMF_00560. Tran_acon_Me_trans.
InterProiIPR029063. SAM-dependent_MTases.
IPR023506. Trans-aconitate_MeTrfase.
IPR023149. Trans_acon_MeTrfase_C.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Identification of genes subject to positive selection in uropathogenic strains of Escherichia coli: a comparative genomics approach."
    Chen S.L., Hung C.-S., Xu J., Reigstad C.S., Magrini V., Sabo A., Blasiar D., Bieri T., Meyer R.R., Ozersky P., Armstrong J.R., Fulton R.S., Latreille J.P., Spieth J., Hooton T.M., Mardis E.R., Hultgren S.J., Gordon J.I.
    Proc. Natl. Acad. Sci. U.S.A. 103:5977-5982(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: UTI89 / UPEC.

Entry informationi

Entry nameiTAM_ECOUT
AccessioniPrimary (citable) accession number: Q1RBP8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 16, 2006
Last modified: November 11, 2015
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.