ID   ADD_ECOUT               Reviewed;         333 AA.
AC   Q1RBH5;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-MAY-2006, sequence version 1.
DT   16-JUN-2009, entry version 18.
DE   RecName: Full=Adenosine deaminase;
DE            EC=3.5.4.4;
DE   AltName: Full=Adenosine aminohydrolase;
GN   Name=add; OrderedLocusNames=UTI89_C1811;
OS   Escherichia coli (strain UTI89 / UPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=364106;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16585510; DOI=10.1073/pnas.0600938103;
RA   Chen S.L., Hung C.-S., Xu J., Reigstad C.S., Magrini V., Sabo A.,
RA   Blasiar D., Bieri T., Meyer R.R., Ozersky P., Armstrong J.R.,
RA   Fulton R.S., Latreille J.P., Spieth J., Hooton T.M., Mardis E.R.,
RA   Hultgren S.J., Gordon J.I.;
RT   "Identification of genes subject to positive selection in
RT   uropathogenic strains of Escherichia coli: a comparative genomics
RT   approach.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:5977-5982(2006).
CC   -!- CATALYTIC ACTIVITY: Adenosine + H(2)O = inosine + NH(3).
CC   -!- SIMILARITY: Belongs to the adenosine and AMP deaminases family.
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DR   EMBL; CP000243; ABE07289.1; -; Genomic_DNA.
DR   RefSeq; YP_540820.1; -.
DR   GeneID; 3992865; -.
DR   GenomeReviews; CP000243_GR; UTI89_C1811.
DR   KEGG; eci:UTI89_C1811; -.
DR   HOGENOM; Q1RBH5; -.
DR   OMA; Q1RBH5; FLKKLDW.
DR   BioCyc; ECOL364106:UTI89_C1811-MON; -.
DR   GO; GO:0004000; F:adenosine deaminase activity; IEA:HAMAP.
DR   GO; GO:0009168; P:purine ribonucleoside monophosphate biosynt...; IEA:HAMAP.
DR   HAMAP; MF_00540; -; 1.
DR   InterPro; IPR006650; A/AMP_deam_AS.
DR   InterPro; IPR001365; A/AMP_deaminase.
DR   InterPro; IPR006330; A_deaminase.
DR   PANTHER; PTHR11409; A/AMP_deaminase; 1.
DR   Pfam; PF00962; A_deaminase; 1.
DR   TIGRFAMs; TIGR01430; aden_deam; 1.
DR   PROSITE; PS00485; A_DEAMINASE; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Hydrolase; Nucleotide metabolism.
FT   CHAIN         1    333       Adenosine deaminase.
FT                                /FTId=PRO_1000017661.
FT   ACT_SITE    197    197       Potential.
FT   ACT_SITE    245    245       Potential.
FT   ACT_SITE    278    278       Potential.
FT   ACT_SITE    279    279       Potential.
SQ   SEQUENCE   333 AA;  36360 MW;  A89FCBC00F5D3F47 CRC64;
     MIDTTLPLTD IHRHLDGNIR PQTILELGRQ YNISLPAQSL ETLIPHVQVI ANEPDLVSFL
     TKLDWGVKVL ASLDACRRVA FENIEDAARN GLHYVELRFS PGYMAMAHQL PVAGVVEAVI
     DGVREGCRTF GVQAKLIGIM SRTFGEAACQ QELEAFLAHR DQITALDLAG DELGFPGSLF
     LSHFNRARDA GWHITVHAGE AAGPESIWQA IRELGAERIG HGVKAIEDRA LMDFLAEQQI
     GIESCLTSNI QTSTVADLAA HPLKTFLEHG IRASINTDDP GVQGVDIIHE YTVAAPAAGL
     SREQIRQAQI NGLEMAFLSA EEKRALREKV AAK
//