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Protein

Carboxy-S-adenosyl-L-methionine synthase

Gene

cmoA

Organism
Escherichia coli (strain UTI89 / UPEC)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM).UniRule annotation

Catalytic activityi

Prephenate + S-adenosyl-L-methionine = phenylpyruvate + carboxy-S-adenosyl-L-methionine + H2O.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei39S-adenosyl-L-methionineUniRule annotation1
Binding sitei132S-adenosyl-L-methionineUniRule annotation1
Binding sitei199S-adenosyl-L-methionineUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
LigandS-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxy-S-adenosyl-L-methionine synthaseUniRule annotation (EC:2.1.3.-UniRule annotation)
Short name:
Cx-SAM synthaseUniRule annotation
Gene namesi
Name:cmoAUniRule annotation
Ordered Locus Names:UTI89_C2074
OrganismiEscherichia coli (strain UTI89 / UPEC)
Taxonomic identifieri364106 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000001952 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003143261 – 247Carboxy-S-adenosyl-L-methionine synthaseAdd BLAST247

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ1RAR4.
SMRiQ1RAR4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni64 – 66S-adenosyl-L-methionine bindingUniRule annotation3
Regioni89 – 90S-adenosyl-L-methionine bindingUniRule annotation2
Regioni117 – 118S-adenosyl-L-methionine bindingUniRule annotation2

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. Cx-SAM synthase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000218457.
KOiK15256.
OMAiMIELYYL.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01589. Cx_SAM_synthase. 1 hit.
InterProiView protein in InterPro
IPR005271. CmoA.
IPR029063. SAM-dependent_MTases.
PIRSFiPIRSF006325. MeTrfase_bac. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00740. TIGR00740. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1RAR4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHRDTLFSA PIARLGDWTF DERVAEVFPD MIQRSVPGYS NIISMIGMLA
60 70 80 90 100
ERFVQPGTQV YDLGCSLGAA TLSVRRNIHH DNCKIIAIDN SPAMIERCRR
110 120 130 140 150
HIDAYKAPTP VDVIEGDIRD IAIENASMVV LNFTLQFLEP SERQALLDKI
160 170 180 190 200
YQGLNPGGAL VLSEKFSFED AKVGELLFNM HHDFKRANGY SELEISQKRS
210 220 230 240
MLENVMLTDS VETHKARLHK AGFEHSELWF QCFNFGSLVA LKAEDAA
Length:247
Mass (Da):27,791
Last modified:May 16, 2006 - v1
Checksum:i2930565165A0A7F4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000243 Genomic DNA. Translation: ABE07550.1.
RefSeqiWP_000019588.1. NC_007946.1.

Genome annotation databases

EnsemblBacteriaiABE07550; ABE07550; UTI89_C2074.
KEGGieci:UTI89_C2074.
PATRICi18453724. VBIEscCol42261_2109.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000243 Genomic DNA. Translation: ABE07550.1.
RefSeqiWP_000019588.1. NC_007946.1.

3D structure databases

ProteinModelPortaliQ1RAR4.
SMRiQ1RAR4.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABE07550; ABE07550; UTI89_C2074.
KEGGieci:UTI89_C2074.
PATRICi18453724. VBIEscCol42261_2109.

Phylogenomic databases

HOGENOMiHOG000218457.
KOiK15256.
OMAiMIELYYL.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01589. Cx_SAM_synthase. 1 hit.
InterProiView protein in InterPro
IPR005271. CmoA.
IPR029063. SAM-dependent_MTases.
PIRSFiPIRSF006325. MeTrfase_bac. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00740. TIGR00740. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCMOA_ECOUT
AccessioniPrimary (citable) accession number: Q1RAR4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 16, 2006
Last modified: February 15, 2017
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.