Reviewed, UniProtKB/Swiss-Prot Q1R9T0 (CDD_ECOUT)

Names and origin

Protein names

Recommended name:
    Cytidine deaminase
    EC=3.5.4.5
Alternative name(s):
    Cytidine aminohydrolase
      Short name=CDA

Gene names

Name:	cdd
Ordered Locus Names:	UTI89_C2416

Organism

Escherichia coli (strain UTI89 / UPEC) [Complete proteome] [HAMAP]

Taxonomic identifier

364106 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length	294 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis By similarity. HAMAP MF_01558
Catalytic activity	Cytidine + H2O = uridine + NH3. HAMAP MF_01558
Cofactor	Binds 1 zinc ion By similarity. HAMAP MF_01558
Subunit structure	Homodimer By similarity. HAMAP MF_01558
Sequence similarities	Belongs to the cytidine and deoxycytidylate deaminase family.

Ontologies

Keywords
Ligand	Metal-binding Zinc
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cytidine metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	cytidine deaminase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 294	294	Cytidine deaminase HAMAP MF_01558		PRO_1000068952
Regions
	Region	89 – 91	3	Substrate binding By similarity
Sites
	Active site	104	1	Proton donor By similarity
	Metal binding	102	1	Zinc; catalytic By similarity
	Metal binding	129	1	Zinc; catalytic By similarity
	Metal binding	132	1	Zinc; catalytic By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q1R9T0-1 [UniParc]. Last modified May 16, 2006. Version 1. Checksum: 69B5CD68AB145D6C	FASTA	294	31,567
	10 20 30 40 50 60 MHPRFQTAFA QLADNLQSAL EPILADKYFP ALLTGEQVSS LKSATGLDED ALAFALLPLA 70 80 90 100 110 120 AACARTPLSN FNVGAIARGV SGTWYFGANM EFIGATMQQT VHAEQSAISH AWLSGEKALA 130 140 150 160 170 180 AITVNYTPCG HCRQFMNELN SGLDLRIHLP GREAHALRDY LPDAFGPKDL EIKTLLMDEQ 190 200 210 220 230 240 DHGYALTGDA LSQAAIAAAN RSHMPYSKSP SGVALECKDG RIFSGSYAEN AAFNPTLPPL 250 260 270 280 290 QGALILLNLK GYDYPDIQRA VLAEKADAPL IQWDATSATL KALGCHNIDR VLLA

References

[1]

"Identification of genes subject to positive selection in uropathogenic strains of Escherichia coli: a comparative genomics approach." Chen S.L., Hung C.-S., Xu J., Reigstad C.S., Magrini V., Sabo A., Blasiar D., Bieri T., Meyer R.R., Ozersky P., Armstrong J.R., Fulton R.S., Latreille J.P., Spieth J., Hooton T.M., Mardis E.R., Hultgren S.J., Gordon J.I. Proc. Natl. Acad. Sci. U.S.A. 103:5977-5982(2006) [PubMed: 16585510] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000243 Genomic DNA. Translation: ABE07884.1.
RefSeq	YP_541415.1.
3D structure databases
SMR	Q1R9T0. Positions 1-294.
ModBase	Search...
Protein-protein interaction databases
STRING	Q1R9T0.
Genome annotation databases
GeneID	3990463.
GenomeReviews	Gene locus UTI89_C2416 in contig CP000243_GR.
KEGG	eci:UTI89_C2416.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0295.
HOGENOM	HBG591160.
OMA	NRSHAPY.
Enzyme and pathway databases
BioCyc	ECOL364106:UTI89_C2416-MONOMER.
Family and domain databases
HAMAP	MF_01558. Cyt_deam. [Tree]
InterPro	IPR016192. APOBEC/CMP_deaminase_Zn-bd. IPR002125. CMP_dCMP_Zn_bd. IPR013171. Cyd/dCyd_deaminase_Zn_bd. IPR006263. Cyt_deam_dimer. IPR016193. Cytidine_deaminase-like. IPR020797. Cytidine_deaminase_bacteria. [Graphical view]
Pfam	PF00383. dCMP_cyt_deam_1. 1 hit. PF08211. dCMP_cyt_deam_2. 1 hit. [Graphical view]
TIGRFAMs	TIGR01355. cyt_deam_dimer. 1 hit.
PROSITE	PS00903. CYT_DCMP_DEAMINASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CDD_ECOUT

Accession

Primary (citable) accession number: Q1R9T0

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	May 16, 2006
Last modified:	February 9, 2010
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)