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Q1R9I4 (UBIG_ECOUT) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-demethylubiquinone-9 3-methyltransferase

EC=2.1.1.64
Alternative name(s):
2-polyprenyl-6-hydroxyphenyl methylase
EC=2.1.1.222
3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase
Short name=DHHB methyltransferase
Gene names
Name:ubiG
Ordered Locus Names:UTI89_C2513
OrganismEscherichia coli (strain UTI89 / UPEC) [Complete proteome] [HAMAP]
Taxonomic identifier364106 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Protein attributes

Sequence length240 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Non-specific O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway By similarity.

Catalytic activity

S-adenosyl-L-methionine + 3-demethylubiquinone-n = S-adenosyl-L-homocysteine + ubiquinone-n. HAMAP MF_00472

S-adenosyl-L-methionine + 3-(all-trans-polyprenyl)benzene-1,2-diol = S-adenosyl-L-homocysteine + 2-methoxy-6-(all-trans-polyprenyl)phenol.

Pathway

Cofactor biosynthesis; ubiquinone biosynthesis. HAMAP MF_00472

Sequence similarities

Belongs to the methyltransferase superfamily. UbiG/COQ3 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 2402403-demethylubiquinone-9 3-methyltransferase HAMAP MF_00472
PRO_1000013900

Sequences

Sequence LengthMass (Da)Tools
Q1R9I4 [UniParc].

Last modified May 16, 2006. Version 1.
Checksum: D4EB4207F06B1657

FASTA24026,559
        10         20         30         40         50         60 
MNAEKSPVNH NVDHEEIAKF EAVASRWWDL EGEFKPLHRI NPLRLGYIAE RAGGLFGKKV 

        70         80         90        100        110        120 
LDVGCGGGIL AESMAREGAT VTGLDMGFEP LQVAKLHALE SGIQVDYVQE TVEEHAAKHA 

       130        140        150        160        170        180 
GQYDVVTCME MLEHVPDPQS VVRACAQLVK PGGDVFFSTL NRNGKSWLMA VVGAEYILRM 

       190        200        210        220        230        240 
VPKGTHDVKK FIKPAELLGW VDQTSLKERH MTGLHYNPIT NSFKLGPGVD VNYMLHTQNK 

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References

[1]"Identification of genes subject to positive selection in uropathogenic strains of Escherichia coli: a comparative genomics approach."
Chen S.L., Hung C.-S., Xu J., Reigstad C.S., Magrini V., Sabo A., Blasiar D., Bieri T., Meyer R.R., Ozersky P., Armstrong J.R., Fulton R.S., Latreille J.P., Spieth J., Hooton T.M., Mardis E.R., Hultgren S.J., Gordon J.I.
Proc. Natl. Acad. Sci. U.S.A. 103:5977-5982(2006) [PubMed: 16585510] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: UTI89 / UPEC.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000243 Genomic DNA. Translation: ABE07980.1.
RefSeqYP_541511.1. NC_007946.1.

3D structure databases

ProteinModelPortalQ1R9I4.
SMRQ1R9I4. Positions 46-157.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ1R9I4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBESCT00000070131; EBESCP00000067609; EBESCG00000069178.
GeneID3992355.
GenomeReviewsGene locus UTI89_C2513 in contig CP000243_GR.
KEGGeci:UTI89_C2513.
PATRIC18454606. VBIEscCol42261_2540.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2227.
GeneTreeEBGT00050000009368.
HOGENOMHBG738842.
OMADHAEIAK.
ProtClustDBPRK05134.

Enzyme and pathway databases

BioCycECOL364106:UTI89_C2513-MONOMER.

Family and domain databases

HAMAPMF_00472. UbiG.
[Tree]
InterProIPR013216. Methyltransf_11.
IPR010233. UbiG_MeTrfase.
[Graphical view]
KOK00568.
PANTHERPTHR23134. PTHR23134. 1 hit.
PfamPF08241. Methyltransf_11. 1 hit.
[Graphical view]
TIGRFAMsTIGR01983. UbiG. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUBIG_ECOUT
AccessionPrimary (citable) accession number: Q1R9I4
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 16, 2006
Last modified: January 25, 2012
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families