Reviewed, UniProtKB/Swiss-Prot Q1R8Z2 (FCTA_ECOUT)

Names and originHide

Protein names

Recommended name:
Formyl-coenzyme A transferase
Short name=Formyl-CoA transferase
EC=2.8.3.16

Gene names

Name:	frc
Ordered Locus Names:	UTI89_C2706

Organism

Escherichia coli (strain UTI89 / UPEC) [Complete proteome] [HAMAP]

Taxonomic identifier

364106 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributesHide

Sequence length	416 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)Hide

Function	Catalyzes the transfer of the CoA moiety from formyl-CoA to oxalate By similarity. HAMAP MF_00742
Catalytic activity	Formyl-CoA + oxalate = formate + oxalyl-CoA. HAMAP MF_00742
Pathway	Metabolic intermediate degradation; oxalate degradation; CO(2) and formate from oxalate: step 1/2. HAMAP MF_00742
Subunit structure	Homodimer By similarity. HAMAP MF_00742
Sequence similarities	Belongs to the caiB/baiF CoA-transferase family.

OntologiesHide

Keywords
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	formyl-CoA transferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)Hide

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 416	416	Formyl-coenzyme A transferase HAMAP MF_00742		PRO_0000300987
Sites
	Active site	169	1	Nucleophile By similarity
	Binding site	96	1	Coenzyme A By similarity

SequencesHide

	Sequence		Length	Mass (Da)
	Q1R8Z2-1 [UniParc]. Last modified May 16, 2006. Version 1. Checksum: 97F7FA4001073301	FASTA	416	45,828
	10 20 30 40 50 60 MSTPLQGIKV LDFTGVQSGP SCTQMLAWFG ADVIKIERPG VGDVTRHQLR DIPDIDALYF 70 80 90 100 110 120 TMLNSNKRSI ELNTKTAEGK EVMEKLIREA DILVENFHPG AIDHMGFTWE HIQEINPRLI 130 140 150 160 170 180 FGSIKGFDEC SPYVNVKAYE NVAQAAGGAA STTGFWDGPP LVSAAALGDS NTGMHLLIGL 190 200 210 220 230 240 LAALLHREKT GRGQRVTMSM QDAVLNLCRV KLRDQQRLDK LGYLEEYPQY PNGTFGDAVP 250 260 270 280 290 300 RGGNAGGGGQ PGWILKCKGW ETDPNAYIYF TIQEQNWENT CKAIGKPEWI TDPAYSTAHA 310 320 330 340 350 360 RQPHIFDIFA EIEKYTVTID KHEAVAYLTQ FDIPCAPVLS MKEISLDPSL RQSGSVVEVE 370 380 390 400 410 QPLRGKYLTV GCPMKFSAFT PDIKAAPLLG EHTAAVLQEL GYSDDEIAAM KQNHAI

ReferencesHide

[1]

"Identification of genes subject to positive selection in uropathogenic strains of Escherichia coli: a comparative genomics approach." Chen S.L., Hung C.-S., Xu J., Reigstad C.S., Magrini V., Sabo A., Blasiar D., Bieri T., Meyer R.R., Ozersky P., Armstrong J.R., Fulton R.S., Latreille J.P., Spieth J., Hooton T.M., Mardis E.R., Hultgren S.J., Gordon J.I. Proc. Natl. Acad. Sci. U.S.A. 103:5977-5982(2006) [PubMed: 16585510] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-referencesHide

Sequence databases
EMBL GenBank DDBJ	CP000243 Genomic DNA. Translation: ABE08172.1.
RefSeq	YP_541703.1.
3D structure databases
SMR	Q1R8Z2. Positions 1-416.
ModBase	Search...
Protein-protein interaction databases
STRING	Q1R8Z2.
Genome annotation databases
EnsemblBacteria	EBESCT00000070424; EBESCP00000067902; EBESCG00000069471.
GeneID	3989766.
GenomeReviews	Gene locus UTI89_C2706 in contig CP000243_GR.
KEGG	eci:UTI89_C2706.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1804.
HOGENOM	HBG659028.
OMA	DEWANDP.
ProtClustDB	PRK05398.
Enzyme and pathway databases
BioCyc	ECOL364106:UTI89_C2706-MONOMER.
Family and domain databases
HAMAP	MF_00742. Formyl-CoA_transfer. [Tree]
InterPro	IPR003673. CoA-Trfase_fam_III. IPR017659. Formyl-CoA_transferase. [Graphical view]
Gene3D	G3DSA:3.40.50.10540. CoA-Trfase_fam_III. 1 hit.
PANTHER	PTHR11837. CAIB_BAIF. 1 hit.
Pfam	PF02515. CoA_transf_3. 1 hit. [Graphical view]
SUPFAM	SSF89796. CoA-Trfase_fam_III. 1 hit.
TIGRFAMs	TIGR03253. oxalate_frc. 1 hit.
ProtoNet	Search...

Entry informationHide

Entry name

FCTA_ECOUT

Accession

Primary (citable) accession number: Q1R8Z2

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	May 16, 2006
Last modified:	July 13, 2010
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)