ID   GLK_ECOUT               Reviewed;         321 AA.
AC   Q1R8X8;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-MAY-2006, sequence version 1.
DT   16-JUN-2009, entry version 20.
DE   RecName: Full=Glucokinase;
DE            EC=2.7.1.2;
DE   AltName: Full=Glucose kinase;
GN   Name=glk; OrderedLocusNames=UTI89_C2720;
OS   Escherichia coli (strain UTI89 / UPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=364106;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16585510; DOI=10.1073/pnas.0600938103;
RA   Chen S.L., Hung C.-S., Xu J., Reigstad C.S., Magrini V., Sabo A.,
RA   Blasiar D., Bieri T., Meyer R.R., Ozersky P., Armstrong J.R.,
RA   Fulton R.S., Latreille J.P., Spieth J., Hooton T.M., Mardis E.R.,
RA   Hultgren S.J., Gordon J.I.;
RT   "Identification of genes subject to positive selection in
RT   uropathogenic strains of Escherichia coli: a comparative genomics
RT   approach.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:5977-5982(2006).
CC   -!- FUNCTION: Not highly important in E.coli as glucose is transported
CC       into the cell by the PTS system already as glucose 6-phosphate.
CC   -!- CATALYTIC ACTIVITY: ATP + D-glucose = ADP + D-glucose 6-phosphate.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the bacterial glucokinase family.
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DR   EMBL; CP000243; ABE08186.1; -; Genomic_DNA.
DR   RefSeq; YP_541717.1; -.
DR   SMR; Q1R8X8; 2-321.
DR   GeneID; 3989780; -.
DR   GenomeReviews; CP000243_GR; UTI89_C2720.
DR   KEGG; eci:UTI89_C2720; -.
DR   HOGENOM; Q1R8X8; -.
DR   OMA; Q1R8X8; VDIGGTH.
DR   BioCyc; ECOL364106:UTI89_C2720-MON; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:HAMAP.
DR   GO; GO:0004340; F:glucokinase activity; IEA:HAMAP.
DR   GO; GO:0006096; P:glycolysis; IEA:HAMAP.
DR   HAMAP; MF_00524; -; 1.
DR   InterPro; IPR003836; Glucokinase.
DR   Pfam; PF02685; Glucokinase; 1.
DR   TIGRFAMs; TIGR00749; glk; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Cytoplasm; Glycolysis; Kinase;
KW   Nucleotide-binding; Transferase.
FT   CHAIN         1    321       Glucokinase.
FT                                /FTId=PRO_0000268772.
FT   NP_BIND       8     13       ATP (Potential).
SQ   SEQUENCE   321 AA;  34709 MW;  42ACBF56627A5C98 CRC64;
     MTKYALVGDV GGTNARLALC DIASGEISQA KTYSGLDYPS LEAVIRVYLE EHKVEVKDGC
     IAIACPITGD WVAMTNHTWA FSIAEMKKNL GFSHLEIIND FTAVSMAIPM LKKEHLIQFG
     GAEPVEGKPI AVYGAGTGLG VAHLVHVDKR WVSLPGEGGH VDFAPNSEEE GIILEILRAE
     IGHVSAERVL SGPGLVNLYR AIVKADNRLP ENLKPKDITE RALADSCTDC RRALSLFCVI
     MGRFGGNLAL NLGTFGGVFI AGGIVPRFLE FFKASGFRAA FEDKGRFKEY VHDIPVYLIV
     HDNPGLLGSG AHLRQTLGHI L
//