Q1R8V2 (PDXK_ECOUT) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 40.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Pyridoxine kinase EC=2.7.1.35 Alternative name(s): PN/PL/PM kinase Pyridoxal kinase Pyridoxamine kinase Vitamin B6 kinase | ||||
| Gene names |
| ||||
| Organism | Escherichia coli (strain UTI89 / UPEC) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 364106 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia |
Protein attributes
| Sequence length | 283 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Phosphorylates B6 vitamers; functions in a salvage pathway. Uses pyridoxal, pyridoxine, and pyridoxamine as substrates By similarity. HAMAP MF_01638 |
| Catalytic activity | ATP + pyridoxal = ADP + pyridoxal 5'-phosphate. HAMAP MF_01638 |
| Cofactor | Zinc or magnesium By similarity. HAMAP MF_01638 |
| Sequence similarities | Belongs to the pyridoxine kinase family. |
Ontologies
| Keywords | |
|---|---|
| Ligand | ATP-binding Magnesium Metal-binding Nucleotide-binding Zinc |
| Molecular function | Kinase Transferase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | pyridoxal 5'-phosphate salvage Inferred from electronic annotation. Source: InterPro |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW metal ion bindingInferred from electronic annotation. Source: UniProtKB-KW pyridoxal kinase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 283 | 283 | Pyridoxine kinase HAMAP MF_01638 | PRO_0000268835 | |||||
Regions | |||||||||
| Nucleotide binding | 195 – 196 | 2 | ATP By similarity | ||||||
| Nucleotide binding | 220 – 232 | 13 | ATP By similarity | ||||||
Sites | |||||||||
| Binding site | 23 | 1 | Substrate By similarity | ||||||
| Binding site | 136 | 1 | Substrate By similarity | ||||||
| Binding site | 233 | 1 | Substrate By similarity | ||||||
Sequences
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References
| [1] | "Identification of genes subject to positive selection in uropathogenic strains of Escherichia coli: a comparative genomics approach." Chen S.L., Hung C.-S., Xu J., Reigstad C.S., Magrini V., Sabo A., Blasiar D., Bieri T., Meyer R.R., Ozersky P., Armstrong J.R., Fulton R.S., Latreille J.P., Spieth J., Hooton T.M., Mardis E.R., Hultgren S.J., Gordon J.I. Proc. Natl. Acad. Sci. U.S.A. 103:5977-5982(2006) [PubMed: 16585510] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: UTI89 / UPEC. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | CP000243 Genomic DNA. Translation: ABE08212.1. |
| RefSeq | YP_541743.1. NC_007946.1. |
3D structure databases | |
| ProteinModelPortal | Q1R8V2. |
| SMR | Q1R8V2. Positions 2-280. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q1R8V2. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblBacteria | EBESCT00000067261; EBESCP00000064739; EBESCG00000066308. |
| GeneID | 3989917. |
| GenomeReviews | Gene locus UTI89_C2752 in contig CP000243_GR. |
| KEGG | eci:UTI89_C2752. |
| PATRIC | 18455056. VBIEscCol42261_2758. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| eggNOG | COG2240. |
| GeneTree | EBGT00050000009567. |
| HOGENOM | HBG661459. |
| OMA | TRDASFL. |
| ProtClustDB | PRK08176. |
Enzyme and pathway databases | |
| BioCyc | ECOL364106:UTI89_C2752-MONOMER. |
Family and domain databases | |
| HAMAP | MF_01638. PdxK. [Tree] |
| InterPro | IPR013749. HMP-P_kinase-1. IPR004625. PyrdxlP_synth_PyrdxlKinase. IPR023479. Pyridoxal_kinase_PdxK. [Graphical view] |
| KO | K00868. |
| PANTHER | PTHR10534. PTHR10534. 1 hit. |
| Pfam | PF08543. Phos_pyr_kin. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR00687. Pyridox_kin. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | PDXK_ECOUT | ||||||||
| Accession | Primary (citable) accession number: Q1R8V2 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |

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