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Reviewed, UniProtKB/Swiss-Prot Q1R8V2 (PDXK_ECOUT)

Last modified June 16, 2009. Version 20. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Pyridoxine kinase
    EC=2.7.1.35
Alternative name(s):
    Pyridoxal kinase
    Vitamin B6 kinase
    Pyridoxamine kinase
    PN/PL/PM kinase
Gene names
Name: pdxK
Ordered Locus Names: UTI89_C2752
OrganismEscherichia coli (strain UTI89 / UPEC) [Complete proteome] [HAMAP]
Taxonomic identifier364106 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Protein attributes

Sequence length283 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Phosphorylates B6 vitamers; functions in a salvage pathway. Uses pyridoxal, pyridoxine, and pyridoxamine as substrates By similarity.

Catalytic activity

ATP + pyridoxal = ADP + pyridoxal 5'-phosphate. HAMAP MF_01638

Cofactor

Zinc or magnesium By similarity.

Sequence similarities

Belongs to the pyridoxine kinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 283283Pyridoxine kinase HAMAP MF_01638
PRO_0000268835

Regions

Nucleotide binding195 – 1962ATP By similarity
Nucleotide binding220 – 23213ATP By similarity

Sites

Binding site231Substrate By similarity
Binding site1361Substrate By similarity
Binding site2331Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q1R8V2-1 [UniParc].

Last modified May 16, 2006. Version 1.
Checksum: 303C85C8DEDA369D

FASTA28330,848
        10         20         30         40         50         60 
MSSLLLFNDK SRALQADIVA VQSQVVYGSV GNSIAVPAIK QNGLNVFAVP TVLLSNTPHY 

        70         80         90        100        110        120 
DTFYGGAIPD EWFSGYLRAL QERDALRQLR AVTTGYMGTA SQIKILAEWL TALRKDHPDL 

       130        140        150        160        170        180 
LIMVDPVIGD IDSGIYVKPD LPEAYRQYLL PLAQGITPNI FELEILTGKD CRDLDSAIAA 

       190        200        210        220        230        240 
AKSLLSDTLK WVVITSASGN EENQEMQVVV VSADSVNVIS HSRVKTDLKG TGDLFCAQLI 

       250        260        270        280 
SGLLKGKALT DAVHRAGLRV LEVMRYTQQH ESDELILPPL AEA 

« Hide

References

[1]"Identification of genes subject to positive selection in uropathogenic strains of Escherichia coli: a comparative genomics approach."
Chen S.L., Hung C.-S., Xu J., Reigstad C.S., Magrini V., Sabo A., Blasiar D., Bieri T., Meyer R.R., Ozersky P., Armstrong J.R., Fulton R.S., Latreille J.P., Spieth J., Hooton T.M., Mardis E.R., Hultgren S.J., Gordon J.I.
Proc. Natl. Acad. Sci. U.S.A. 103:5977-5982(2006) [PubMed: 16585510] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

CP000243 Genomic DNA. Translation: ABE08212.1.
RefSeqYP_541743.1.

3D structure databases

SMRQ1R8V2. Positions 2-280.
ModBaseSearch...

Genome annotation databases

GeneID3989917.
GenomeReviewsGene locus UTI89_C2752 in contig CP000243_GR.
KEGGeci:UTI89_C2752.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ1R8V2.
OMAQ1R8V2. ACICNEL.

Enzyme and pathway databases

BioCycECOL364106:UTI89_C2752-MON.

Family and domain databases

HAMAPMF_01638.
[Tree]
InterProIPR013749. HMP-P_kinase-1.
IPR004625. PyrdxlP_synth_PyrdxlKinase.
[Graphical view]
PfamPF08543. Phos_pyr_kin. 1 hit.
[Graphical view]
TIGRFAMsTIGR00687. pyridox_kin. 1 hit.
ProtoNetSearch...

Entry information

Entry namePDXK_ECOUT
AccessionPrimary (citable) accession number: Q1R8V2
Entry history
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: May 16, 2006
Last modified: June 16, 2009
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents