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Protein

Pseudouridine synthase

Gene

rluD

Organism
Escherichia coli (strain UTI89 / UPEC)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Responsible for synthesis of pseudouridine from uracil.UniRule annotation

Catalytic activityi

RNA uridine = RNA pseudouridine.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotation, LyaseImported

Enzyme and pathway databases

BioCyciECOL364106:GHPQ-2904-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Pseudouridine synthaseUniRule annotation (EC:5.4.99.-UniRule annotation)
Gene namesi
Name:rluDImported
Ordered Locus Names:UTI89_C2927Imported
OrganismiEscherichia coli (strain UTI89 / UPEC)Imported
Taxonomic identifieri364106 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000001952 Componenti: Chromosome

Structurei

3D structure databases

ProteinModelPortaliQ1R8D1.
SMRiQ1R8D1. Positions 2-325.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pseudouridine synthase RluA family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0564.
HOGENOMiHOG000275919.
KOiK06180.
OMAiTYGGRPR.
OrthoDBiEOG6P070X.

Family and domain databases

Gene3Di3.10.290.10. 1 hit.
InterProiIPR020103. PsdUridine_synth_cat_dom.
IPR006225. PsdUridine_synth_RluC/D.
IPR006224. PsdUridine_synth_RluC/D_CS.
IPR006145. PsdUridine_synth_RsuA/RluD.
IPR002942. S4_RNA-bd.
[Graphical view]
PfamiPF00849. PseudoU_synth_2. 1 hit.
PF01479. S4. 1 hit.
[Graphical view]
SMARTiSM00363. S4. 1 hit.
[Graphical view]
SUPFAMiSSF55120. SSF55120. 1 hit.
TIGRFAMsiTIGR00005. rluA_subfam. 1 hit.
PROSITEiPS01129. PSI_RLU. 1 hit.
PS50889. S4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1R8D1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQRVQLTAT VSENQLGQRL DQALAEMFPD YSRSRIKEWI LDQRVLVNGK
60 70 80 90 100
VCDKPKEKVL GGEQVAINAE IEEEARFEPQ DIPLDIVYED EDIIVINKPR
110 120 130 140 150
DLVVHPGAGN PDGTVLNALL HYYPPIADVP RAGIVHRLDK DTTGLMVVAK
160 170 180 190 200
TVPAQTRLVE SLQRREITRE YEAVAIGHMT AGGTVDEPIS RHPTKRTHMA
210 220 230 240 250
VHPMGKPAVT HYRIMEHFRV HTRLRLRLET GRTHQIRVHM AHITHPLVGD
260 270 280 290 300
PVYGGRPRPP KGASEAFIST LRKFDRQSLH ATMLRLYHPI SGIEMEWHAP
310 320
IPQDMVELIE VMRADFEEHK DEVDWL
Length:326
Mass (Da):37,124
Last modified:May 16, 2006 - v1
Checksum:i11CF5F1D30CF882D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000243 Genomic DNA. Translation: ABE08383.1.
RefSeqiWP_000079114.1. NC_007946.1.
YP_541914.1. NC_007946.1.

Genome annotation databases

EnsemblBacteriaiABE08383; ABE08383; UTI89_C2927.
KEGGieci:UTI89_C2927.
PATRICi18455382. VBIEscCol42261_2917.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000243 Genomic DNA. Translation: ABE08383.1.
RefSeqiWP_000079114.1. NC_007946.1.
YP_541914.1. NC_007946.1.

3D structure databases

ProteinModelPortaliQ1R8D1.
SMRiQ1R8D1. Positions 2-325.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABE08383; ABE08383; UTI89_C2927.
KEGGieci:UTI89_C2927.
PATRICi18455382. VBIEscCol42261_2917.

Phylogenomic databases

eggNOGiCOG0564.
HOGENOMiHOG000275919.
KOiK06180.
OMAiTYGGRPR.
OrthoDBiEOG6P070X.

Enzyme and pathway databases

BioCyciECOL364106:GHPQ-2904-MONOMER.

Family and domain databases

Gene3Di3.10.290.10. 1 hit.
InterProiIPR020103. PsdUridine_synth_cat_dom.
IPR006225. PsdUridine_synth_RluC/D.
IPR006224. PsdUridine_synth_RluC/D_CS.
IPR006145. PsdUridine_synth_RsuA/RluD.
IPR002942. S4_RNA-bd.
[Graphical view]
PfamiPF00849. PseudoU_synth_2. 1 hit.
PF01479. S4. 1 hit.
[Graphical view]
SMARTiSM00363. S4. 1 hit.
[Graphical view]
SUPFAMiSSF55120. SSF55120. 1 hit.
TIGRFAMsiTIGR00005. rluA_subfam. 1 hit.
PROSITEiPS01129. PSI_RLU. 1 hit.
PS50889. S4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Identification of genes subject to positive selection in uropathogenic strains of Escherichia coli: a comparative genomics approach."
    Chen S.L., Hung C.-S., Xu J., Reigstad C.S., Magrini V., Sabo A., Blasiar D., Bieri T., Meyer R.R., Ozersky P., Armstrong J.R., Fulton R.S., Latreille J.P., Spieth J., Hooton T.M., Mardis E.R., Hultgren S.J., Gordon J.I.
    Proc. Natl. Acad. Sci. U.S.A. 103:5977-5982(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: UTI89 / UPECImported.

Entry informationi

Entry nameiQ1R8D1_ECOUT
AccessioniPrimary (citable) accession number: Q1R8D1
Entry historyi
Integrated into UniProtKB/TrEMBL: May 16, 2006
Last sequence update: May 16, 2006
Last modified: June 24, 2015
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.