ID   TTDA_ECOUT              Reviewed;         303 AA.
AC   Q1R6S0;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-MAY-2006, sequence version 1.
DT   16-JUN-2009, entry version 19.
DE   RecName: Full=L(+)-tartrate dehydratase subunit alpha;
DE            Short=L-TTD alpha;
DE            EC=4.2.1.32;
GN   Name=ttdA; OrderedLocusNames=UTI89_C3497;
OS   Escherichia coli (strain UTI89 / UPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=364106;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16585510; DOI=10.1073/pnas.0600938103;
RA   Chen S.L., Hung C.-S., Xu J., Reigstad C.S., Magrini V., Sabo A.,
RA   Blasiar D., Bieri T., Meyer R.R., Ozersky P., Armstrong J.R.,
RA   Fulton R.S., Latreille J.P., Spieth J., Hooton T.M., Mardis E.R.,
RA   Hultgren S.J., Gordon J.I.;
RT   "Identification of genes subject to positive selection in
RT   uropathogenic strains of Escherichia coli: a comparative genomics
RT   approach.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:5977-5982(2006).
CC   -!- CATALYTIC ACTIVITY: (R,R)-tartrate = oxaloacetate + H(2)O.
CC   -!- COFACTOR: Iron-sulfur (By similarity).
CC   -!- SUBUNIT: Tetramer of two alpha and two beta subunits (By
CC       similarity).
CC   -!- INDUCTION: Induced by tartrate, via ttdR (By similarity).
CC   -!- SIMILARITY: Belongs to the class-I fumarase family.
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DR   EMBL; CP000243; ABE08944.1; -; Genomic_DNA.
DR   RefSeq; YP_542475.1; -.
DR   GeneID; 3993903; -.
DR   GenomeReviews; CP000243_GR; UTI89_C3497.
DR   KEGG; eci:UTI89_C3497; -.
DR   HOGENOM; Q1R6S0; -.
DR   OMA; Q1R6S0; VNACPPL.
DR   BioCyc; ECOL364106:UTI89_C3497-MON; -.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0005506; F:iron ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0008730; F:L(+)-tartrate dehydratase activity; IEA:EC.
DR   InterPro; IPR004646; TtdA_fumA_fumB.
DR   Pfam; PF05681; Fumerase; 1.
DR   TIGRFAMs; TIGR00722; ttdA_fumA_fumB; 1.
PE   2: Evidence at transcript level;
KW   4Fe-4S; Complete proteome; Iron; Iron-sulfur; Lyase; Metal-binding.
FT   CHAIN         1    303       L(+)-tartrate dehydratase subunit alpha.
FT                                /FTId=PRO_0000262699.
FT   METAL        71     71       Iron-sulfur (By similarity).
FT   METAL       190    190       Iron-sulfur (By similarity).
FT   METAL       277    277       Iron-sulfur (By similarity).
SQ   SEQUENCE   303 AA;  32706 MW;  720CA4CDBA8B6136 CRC64;
     MMSESNKQQA VNKLTEIVAN FTAMISTRMP DDVVDKLKQL KDAETSSMGK IIYHTMFDNM
     QKAIDLNRPA CQDTGEIMFF VKVGSRFPLL GELQSILKQA VEEATVKAPL RHNAVEIFDE
     VNTGKNTGSG VPWVTWDIVP DGDDAEIEVY MAGGGCTLPG RSKVLMPSEG YEGVVKFVFE
     NISTLAVNAC PPVLVGVGIA TSVETAAVLS RKAILRPIGS RHPNPKAAEL ELRLEEGLNR
     LGIGPQGLTG NSSVMGVHIE SAARHPSTIG VAVSTGCWAH RRGTLRVHAD LTFENLSHTR
     SAL
//