ID   NUDC_ECOUT              Reviewed;         257 AA.
AC   Q1R5W2;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-MAY-2006, sequence version 1.
DT   16-JUN-2009, entry version 24.
DE   RecName: Full=NADH pyrophosphatase;
DE            EC=3.6.1.22;
GN   Name=nudC; OrderedLocusNames=UTI89_C3823;
OS   Escherichia coli (strain UTI89 / UPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=364106;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16585510; DOI=10.1073/pnas.0600938103;
RA   Chen S.L., Hung C.-S., Xu J., Reigstad C.S., Magrini V., Sabo A.,
RA   Blasiar D., Bieri T., Meyer R.R., Ozersky P., Armstrong J.R.,
RA   Fulton R.S., Latreille J.P., Spieth J., Hooton T.M., Mardis E.R.,
RA   Hultgren S.J., Gordon J.I.;
RT   "Identification of genes subject to positive selection in
RT   uropathogenic strains of Escherichia coli: a comparative genomics
RT   approach.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:5977-5982(2006).
CC   -!- CATALYTIC ACTIVITY: NAD(+) + H(2)O = AMP + NMN.
CC   -!- COFACTOR: Divalent ions. Manganese or magnesium (By similarity).
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SIMILARITY: Belongs to the Nudix hydrolase family. NudC subfamily.
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DR   EMBL; CP000243; ABE09252.1; -; Genomic_DNA.
DR   RefSeq; YP_542783.1; -.
DR   SMR; Q1R5W2; 1-257.
DR   GeneID; 3990796; -.
DR   GenomeReviews; CP000243_GR; UTI89_C3823.
DR   KEGG; eci:UTI89_C3823; -.
DR   HOGENOM; Q1R5W2; -.
DR   OMA; Q1R5W2; SPCIIVA.
DR   BioCyc; ECOL364106:UTI89_C3823-MON; -.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:HAMAP.
DR   GO; GO:0030145; F:manganese ion binding; IEA:HAMAP.
DR   GO; GO:0000210; F:NAD+ diphosphatase activity; IEA:HAMAP.
DR   HAMAP; MF_00297; -; 1.
DR   InterPro; IPR015375; NADH_PPase-like_N.
DR   InterPro; IPR000086; NUDIX_hydrolase_core.
DR   InterPro; IPR015376; Znr_NADH_PPase.
DR   Gene3D; G3DSA:3.90.79.10; NUDIX_hydrolase; 1.
DR   Pfam; PF00293; NUDIX; 1.
DR   Pfam; PF09296; NUDIX-like; 1.
DR   Pfam; PF09297; zf-NADH-PPase; 1.
DR   PROSITE; PS00893; NUDIX; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Hydrolase; Magnesium; Manganese; NAD.
FT   CHAIN         1    257       NADH pyrophosphatase.
FT                                /FTId=PRO_1000021906.
FT   MOTIF       159    180       Nudix box.
SQ   SEQUENCE   257 AA;  29711 MW;  BC1CB18239B43F3E CRC64;
     MDRIIEKLDH GWWVVSHEQK LWLPKGELPY GEAANFDLVG QRALQIGEWQ GEPVWLVQLQ
     RRHDMGSVRQ VIDLDVGLFQ LAGRGVQLAE FYRSHKYCGY CGHEMYPSKT EWAMLCSHCR
     ERYYPQIAPC IIVAIRRDDS ILLAQHTRHR NGVHTVLAGF VEVGETLEQA VAREVMEESG
     IKVKNLRYVT SQPWPFPQSL MTAFMAEYDS GEIVIDPKEL LEAHWYRYDD LPLLPPPGTV
     ARRLIEDTVA MCRAEYE
//