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Protein

Glutamate decarboxylase

Gene

gadA

Organism
Escherichia coli (strain UTI89 / UPEC)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamate = 4-aminobutanoate + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. glutamate decarboxylase activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glutamate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

DecarboxylaseUniRule annotation, Lyase

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Enzyme and pathway databases

BioCyciECOL364106:GHPQ-4012-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate decarboxylaseUniRule annotation (EC:4.1.1.15UniRule annotation)
Gene namesi
Name:gadAImported
Ordered Locus Names:UTI89_C4049Imported
OrganismiEscherichia coli (strain UTI89 / UPEC)Imported
Taxonomic identifieri364106 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000001952 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi364106.UTI89_C4049.

Structurei

3D structure databases

ProteinModelPortaliQ1R586.
SMRiQ1R586. Positions 25-473.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0076.
HOGENOMiHOG000070228.
KOiK01580.
OMAiDPDLVWD.
OrthoDBiEOG6TFCPW.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR021115. Pyridoxal-P_BS.
[Graphical view]
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.
PROSITEiPS00392. DDC_GAD_HDC_YDC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1R586-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPLRINPTF LLPSNKFKEF EMDQKLLTDF RSELLDSRFG AKAISTIAES
60 70 80 90 100
KRFPLHEMRD DVAFQIINDE LYLDGNARQN LATFCQTWDD ENVHKLMDLS
110 120 130 140 150
INKNWIDKEE YPQSAAIDLR CVNMVADLWH APAPKNGQAV GTNTIGSSEA
160 170 180 190 200
CMLGGMAMKW RWRKRMEAAG KPTNKPNLVC GPVQICWHKF ARYWDVELRE
210 220 230 240 250
IPMRPGQLFM DPKRMIEACD ENTIGVVPTF GVTYTGNYEF PQPLHDALDK
260 270 280 290 300
FQADTGIDID MHIDAASGGF LAPFVAPDIV WDFRLPRVKS ISASGHKFGL
310 320 330 340 350
APLGCGWVIW RDEEALPQEL VFNVDYLGGQ IGTFAINFSR PAGQVIAQYY
360 370 380 390 400
EFLRLGREGY TKVQNASYQV AAYLADEIAK LGPYEFICTG RPDEGIPAVC
410 420 430 440 450
FKLKDGEDPG YTLYDLSERL RLRGWQVPAF TLGGEATDIV VMRIMCRRGF
460 470 480
EMDFAELLLE DYKASLKYLS DHPKLQGIAQ QNSFKHT
Length:487
Mass (Da):55,201
Last modified:May 16, 2006 - v1
Checksum:iDF925137BA525680
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000243 Genomic DNA. Translation: ABE09478.1.
RefSeqiWP_011478294.1. NC_007946.1.
YP_543009.1. NC_007946.1.

Genome annotation databases

EnsemblBacteriaiABE09478; ABE09478; UTI89_C4049.
KEGGieci:UTI89_C4049.
PATRICi18457527. VBIEscCol42261_3962.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000243 Genomic DNA. Translation: ABE09478.1.
RefSeqiWP_011478294.1. NC_007946.1.
YP_543009.1. NC_007946.1.

3D structure databases

ProteinModelPortaliQ1R586.
SMRiQ1R586. Positions 25-473.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi364106.UTI89_C4049.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABE09478; ABE09478; UTI89_C4049.
KEGGieci:UTI89_C4049.
PATRICi18457527. VBIEscCol42261_3962.

Phylogenomic databases

eggNOGiCOG0076.
HOGENOMiHOG000070228.
KOiK01580.
OMAiDPDLVWD.
OrthoDBiEOG6TFCPW.

Enzyme and pathway databases

BioCyciECOL364106:GHPQ-4012-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR021115. Pyridoxal-P_BS.
[Graphical view]
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.
PROSITEiPS00392. DDC_GAD_HDC_YDC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Identification of genes subject to positive selection in uropathogenic strains of Escherichia coli: a comparative genomics approach."
    Chen S.L., Hung C.-S., Xu J., Reigstad C.S., Magrini V., Sabo A., Blasiar D., Bieri T., Meyer R.R., Ozersky P., Armstrong J.R., Fulton R.S., Latreille J.P., Spieth J., Hooton T.M., Mardis E.R., Hultgren S.J., Gordon J.I.
    Proc. Natl. Acad. Sci. U.S.A. 103:5977-5982(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: UTI89 / UPECImported.

Entry informationi

Entry nameiQ1R586_ECOUT
AccessioniPrimary (citable) accession number: Q1R586
Entry historyi
Integrated into UniProtKB/TrEMBL: May 16, 2006
Last sequence update: May 16, 2006
Last modified: April 1, 2015
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.