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Q1R586

- Q1R586_ECOUT

UniProt

Q1R586 - Q1R586_ECOUT

Protein

Glutamate decarboxylase

Gene

gadA

Organism
Escherichia coli (strain UTI89 / UPEC)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (16 May 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    L-glutamate = 4-aminobutanoate + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glutamate decarboxylase activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glutamate metabolic process Source: InterPro

    Keywords - Molecular functioni

    DecarboxylaseUniRule annotation, Lyase

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotation

    Enzyme and pathway databases

    BioCyciECOL364106:GHPQ-4012-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate decarboxylaseUniRule annotation (EC:4.1.1.15UniRule annotation)
    Gene namesi
    Name:gadAImported
    Ordered Locus Names:UTI89_C4049Imported
    OrganismiEscherichia coli (strain UTI89 / UPEC)Imported
    Taxonomic identifieri364106 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000001952: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi364106.UTI89_C4049.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1R586.
    SMRiQ1R586. Positions 25-473.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the group II decarboxylase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0076.
    HOGENOMiHOG000070228.
    KOiK01580.
    OMAiMIGRLFN.
    OrthoDBiEOG6TFCPW.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    InterProiIPR010107. Glutamate_decarboxylase.
    IPR002129. PyrdxlP-dep_de-COase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR021115. Pyridoxal-P_BS.
    [Graphical view]
    PfamiPF00282. Pyridoxal_deC. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.
    PROSITEiPS00392. DDC_GAD_HDC_YDC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q1R586-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLPLRINPTF LLPSNKFKEF EMDQKLLTDF RSELLDSRFG AKAISTIAES    50
    KRFPLHEMRD DVAFQIINDE LYLDGNARQN LATFCQTWDD ENVHKLMDLS 100
    INKNWIDKEE YPQSAAIDLR CVNMVADLWH APAPKNGQAV GTNTIGSSEA 150
    CMLGGMAMKW RWRKRMEAAG KPTNKPNLVC GPVQICWHKF ARYWDVELRE 200
    IPMRPGQLFM DPKRMIEACD ENTIGVVPTF GVTYTGNYEF PQPLHDALDK 250
    FQADTGIDID MHIDAASGGF LAPFVAPDIV WDFRLPRVKS ISASGHKFGL 300
    APLGCGWVIW RDEEALPQEL VFNVDYLGGQ IGTFAINFSR PAGQVIAQYY 350
    EFLRLGREGY TKVQNASYQV AAYLADEIAK LGPYEFICTG RPDEGIPAVC 400
    FKLKDGEDPG YTLYDLSERL RLRGWQVPAF TLGGEATDIV VMRIMCRRGF 450
    EMDFAELLLE DYKASLKYLS DHPKLQGIAQ QNSFKHT 487
    Length:487
    Mass (Da):55,201
    Last modified:May 16, 2006 - v1
    Checksum:iDF925137BA525680
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000243 Genomic DNA. Translation: ABE09478.1.
    RefSeqiYP_543009.1. NC_007946.1.

    Genome annotation databases

    EnsemblBacteriaiABE09478; ABE09478; UTI89_C4049.
    GeneIDi3991128.
    KEGGieci:UTI89_C4049.
    PATRICi18457527. VBIEscCol42261_3962.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000243 Genomic DNA. Translation: ABE09478.1 .
    RefSeqi YP_543009.1. NC_007946.1.

    3D structure databases

    ProteinModelPortali Q1R586.
    SMRi Q1R586. Positions 25-473.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 364106.UTI89_C4049.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABE09478 ; ABE09478 ; UTI89_C4049 .
    GeneIDi 3991128.
    KEGGi eci:UTI89_C4049.
    PATRICi 18457527. VBIEscCol42261_3962.

    Phylogenomic databases

    eggNOGi COG0076.
    HOGENOMi HOG000070228.
    KOi K01580.
    OMAi MIGRLFN.
    OrthoDBi EOG6TFCPW.

    Enzyme and pathway databases

    BioCyci ECOL364106:GHPQ-4012-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    InterProi IPR010107. Glutamate_decarboxylase.
    IPR002129. PyrdxlP-dep_de-COase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR021115. Pyridoxal-P_BS.
    [Graphical view ]
    Pfami PF00282. Pyridoxal_deC. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR01788. Glu-decarb-GAD. 1 hit.
    PROSITEi PS00392. DDC_GAD_HDC_YDC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of genes subject to positive selection in uropathogenic strains of Escherichia coli: a comparative genomics approach."
      Chen S.L., Hung C.-S., Xu J., Reigstad C.S., Magrini V., Sabo A., Blasiar D., Bieri T., Meyer R.R., Ozersky P., Armstrong J.R., Fulton R.S., Latreille J.P., Spieth J., Hooton T.M., Mardis E.R., Hultgren S.J., Gordon J.I.
      Proc. Natl. Acad. Sci. U.S.A. 103:5977-5982(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: UTI89 / UPECImported.

    Entry informationi

    Entry nameiQ1R586_ECOUT
    AccessioniPrimary (citable) accession number: Q1R586
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 16, 2006
    Last sequence update: May 16, 2006
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3