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Protein

Nucleoid occlusion factor SlmA

Gene

ttk

Organism
Escherichia coli (strain UTI89 / UPEC)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions.UniRule annotationSAAS annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi47 – 66H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingUniRule annotationSAAS annotation
Biological processCell cycle, Cell divisionUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoid occlusion factor SlmAUniRule annotationSAAS annotation
Gene namesi
Name:ttkImported
Synonyms:slmAUniRule annotation
Ordered Locus Names:UTI89_C4185Imported
OrganismiEscherichia coli (strain UTI89 / UPEC)Imported
Taxonomic identifieri364106 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000001952 Componenti: Chromosome

Subcellular locationi

  • Cytoplasmnucleoid SAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homodimer. Interacts with FtsZ.SAAS annotation

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4GCLX-ray2.65A/B/C/D/E/F/G/H1-212[»]
ProteinModelPortaliQ1R4V1.
SMRiQ1R4V1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 84HTH tetR-type DNA-bindingInterPro annotationAdd BLAST61

Sequence similaritiesi

Belongs to the nucleoid occlusion factor SlmA family.UniRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSAAS annotation

Phylogenomic databases

HOGENOMiHOG000266053.
KOiK05501.
OMAiRNPGITR.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
HAMAPiMF_01839. NO_factor_SlmA. 1 hit.
InterProiView protein in InterPro
IPR023772. DNA-bd_HTH_TetR-type_CS.
IPR009057. Homeobox-like.
IPR001647. HTH_TetR.
IPR023769. NO_SlmA.
IPR011075. Tet_transcr_reg_TetR-rel_C.
PfamiView protein in Pfam
PF00440. TetR_N. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF48498. SSF48498. 1 hit.
PROSITEiView protein in PROSITE
PS01081. HTH_TETR_1. 1 hit.
PS50977. HTH_TETR_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1R4V1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPGKCLFSG VFCNMAEKQT AKRNRREEIL QSLALMLESS DGSQRITTAK
60 70 80 90 100
LAASVGVSEA ALYRHFPSKT RMFDSLIEFI EDSLITRINL ILKDEKDTTA
110 120 130 140 150
RLRLIVLLLL GFGERNPGLT RILTGHALMF EQDRLQGRIN QLFERIEAQL
160 170 180 190 200
RQVLREKRMR EGEGYATDET LLASQILAFC EGMLSRFVRS EFKYRPTDDF
210
DARWPLIAAQ LQ
Length:212
Mass (Da):24,288
Last modified:May 16, 2006 - v1
Checksum:i378A696615488F38
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000243 Genomic DNA. Translation: ABE09613.1.

Genome annotation databases

EnsemblBacteriaiABE09613; ABE09613; UTI89_C4185.
KEGGieci:UTI89_C4185.
PATRICi18457790. VBIEscCol42261_4092.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000243 Genomic DNA. Translation: ABE09613.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4GCLX-ray2.65A/B/C/D/E/F/G/H1-212[»]
ProteinModelPortaliQ1R4V1.
SMRiQ1R4V1.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABE09613; ABE09613; UTI89_C4185.
KEGGieci:UTI89_C4185.
PATRICi18457790. VBIEscCol42261_4092.

Phylogenomic databases

HOGENOMiHOG000266053.
KOiK05501.
OMAiRNPGITR.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
HAMAPiMF_01839. NO_factor_SlmA. 1 hit.
InterProiView protein in InterPro
IPR023772. DNA-bd_HTH_TetR-type_CS.
IPR009057. Homeobox-like.
IPR001647. HTH_TetR.
IPR023769. NO_SlmA.
IPR011075. Tet_transcr_reg_TetR-rel_C.
PfamiView protein in Pfam
PF00440. TetR_N. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF48498. SSF48498. 1 hit.
PROSITEiView protein in PROSITE
PS01081. HTH_TETR_1. 1 hit.
PS50977. HTH_TETR_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ1R4V1_ECOUT
AccessioniPrimary (citable) accession number: Q1R4V1
Entry historyiIntegrated into UniProtKB/TrEMBL: May 16, 2006
Last sequence update: May 16, 2006
Last modified: April 12, 2017
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.