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Q1R4V1 (Q1R4V1_ECOUT) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Nucleoid occlusion factor SlmA HAMAP-Rule MF_01839
Gene names
Name:ttk EMBL ABE09613.1
Synonyms:slmA HAMAP-Rule MF_01839
Ordered Locus Names:UTI89_C4185 EMBL ABE09613.1
OrganismEscherichia coli (strain UTI89 / UPEC) [Complete proteome] [HAMAP] EMBL ABE09613.1
Taxonomic identifier364106 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Protein attributes

Sequence length212 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions By similarity. HAMAP-Rule MF_01839 SAAS SAAS011075

Subunit structure

Homodimer. Interacts with FtsZ By similarity. HAMAP-Rule MF_01839

Subcellular location

Cytoplasmnucleoid By similarity HAMAP-Rule MF_01839 SAAS SAAS011075.

Sequence similarities

Belongs to the nucleoid occlusion factor SlmA family. HAMAP-Rule MF_01839

Contains 1 HTH tetR-type DNA-binding domain. HAMAP-Rule MF_01839

Contains HTH tetR-type DNA-binding domain. SAAS SAAS011075

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain24 – 8461HTH tetR-type By similarity HAMAP-Rule MF_01839
DNA binding47 – 6620H-T-H motif By similarity HAMAP-Rule MF_01839
Coiled coil131 – 15828 By similarity HAMAP-Rule MF_01839

Sequences

Sequence LengthMass (Da)Tools
Q1R4V1 [UniParc].

Last modified May 16, 2006. Version 1.
Checksum: 378A696615488F38

FASTA21224,288
        10         20         30         40         50         60 
MPPGKCLFSG VFCNMAEKQT AKRNRREEIL QSLALMLESS DGSQRITTAK LAASVGVSEA 

        70         80         90        100        110        120 
ALYRHFPSKT RMFDSLIEFI EDSLITRINL ILKDEKDTTA RLRLIVLLLL GFGERNPGLT 

       130        140        150        160        170        180 
RILTGHALMF EQDRLQGRIN QLFERIEAQL RQVLREKRMR EGEGYATDET LLASQILAFC 

       190        200        210 
EGMLSRFVRS EFKYRPTDDF DARWPLIAAQ LQ 

« Hide

References

« Hide 'large scale' references
[1]"Identification of genes subject to positive selection in uropathogenic strains of Escherichia coli: a comparative genomics approach."
Chen S.L., Hung C.S., Xu J., Reigstad C.S., Magrini V., Sabo A., Blasiar D., Bieri T., Meyer R.R., Ozersky P., Armstrong J.R., Fulton R.S., Latreille J.P., Spieth J., Hooton T.M., Mardis E.R., Hultgren S.J., Gordon J.I.
Proc. Natl. Acad. Sci. U.S.A. 103:5977-5982(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: UTI89 / UPEC.
[2]"SlmA forms a higher-order structure on DNA that inhibits cytokinetic Z-ring formation over the nucleoid."
Tonthat N.K., Milam S.L., Chinnam N., Whitfill T., Margolin W., Schumacher M.A.
Proc. Natl. Acad. Sci. U.S.A. 110:10586-10591(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.65 ANGSTROMS).

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000243 Genomic DNA. Translation: ABE09613.1.
RefSeqYP_543144.2. NC_007946.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4GCLX-ray2.65A/B/C/D/E/F/G/H1-212[»]
ProteinModelPortalQ1R4V1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING364106.UTI89_C4185.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABE09613; ABE09613; UTI89_C4185.
GeneID3991319.
KEGGeci:UTI89_C4185.
PATRIC18457790. VBIEscCol42261_4092.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1309.
HOGENOMHOG000266053.
KOK05501.
OMAEKDTSAR.
OrthoDBEOG6G7R3C.
ProtClustDBPRK09480.

Enzyme and pathway databases

BioCycECOL364106:GHPQ-4147-MONOMER.

Family and domain databases

Gene3D1.10.357.10. 1 hit.
HAMAPMF_01839. NO_factor_SlmA.
InterProIPR023772. DNA-bd_HTH_TetR-type_CS.
IPR009057. Homeodomain-like.
IPR001647. HTH_TetR.
IPR023769. NO_SlmA.
IPR015893. Tet_transcr_reg_TetR-like_C.
IPR011075. Tet_transcr_reg_TetR-rel_C.
[Graphical view]
PfamPF00440. TetR_N. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
SSF48498. SSF48498. 1 hit.
PROSITEPS01081. HTH_TETR_1. 1 hit.
PS50977. HTH_TETR_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ1R4V1_ECOUT
AccessionPrimary (citable) accession number: Q1R4V1
Entry history
Integrated into UniProtKB/TrEMBL: May 16, 2006
Last sequence update: May 16, 2006
Last modified: February 19, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)