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Q1R4V1

- Q1R4V1_ECOUT

UniProt

Q1R4V1 - Q1R4V1_ECOUT

Protein

Nucleoid occlusion factor SlmA

Gene

ttk

Organism
Escherichia coli (strain UTI89 / UPEC)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (16 May 2006)
      Previous versions | rss
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    Functioni

    Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions.UniRule annotationSAAS annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi47 – 6620H-T-H motifUniRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. negative regulation of barrier septum assembly Source: InterPro

    Keywords - Biological processi

    Cell cycle, Cell divisionUniRule annotationSAAS annotation

    Keywords - Ligandi

    DNA-bindingUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciECOL364106:GHPQ-4147-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nucleoid occlusion factor SlmAUniRule annotation
    Gene namesi
    Name:ttkImported
    Synonyms:slmAUniRule annotation
    Ordered Locus Names:UTI89_C4185Imported
    OrganismiEscherichia coli (strain UTI89 / UPEC)Imported
    Taxonomic identifieri364106 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000001952: Chromosome

    Subcellular locationi

    Cytoplasmnucleoid UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. bacterial nucleoid Source: UniProtKB-HAMAP
    2. cytoplasm Source: UniProtKB-HAMAP

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    Interactioni

    Subunit structurei

    Homodimer. Interacts with FtsZ.UniRule annotation

    Protein-protein interaction databases

    STRINGi364106.UTI89_C4185.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4GCLX-ray2.65A/B/C/D/E/F/G/H1-212[»]
    ProteinModelPortaliQ1R4V1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini24 – 8461HTH tetR-typeUniRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili131 – 15828UniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the nucleoid occlusion factor SlmA family.UniRule annotation
    Contains 1 HTH tetR-type DNA-binding domain.UniRule annotation
    Contains HTH tetR-type DNA-binding domain.SAAS annotation

    Keywords - Domaini

    Coiled coilUniRule annotation

    Phylogenomic databases

    eggNOGiCOG1309.
    HOGENOMiHOG000266053.
    KOiK05501.
    OMAiEKDTSAR.
    OrthoDBiEOG6G7R3C.

    Family and domain databases

    Gene3Di1.10.357.10. 1 hit.
    HAMAPiMF_01839. NO_factor_SlmA.
    InterProiIPR023772. DNA-bd_HTH_TetR-type_CS.
    IPR009057. Homeodomain-like.
    IPR001647. HTH_TetR.
    IPR023769. NO_SlmA.
    IPR015893. Tet_transcr_reg_TetR-like_C.
    IPR011075. Tet_transcr_reg_TetR-rel_C.
    [Graphical view]
    PfamiPF00440. TetR_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    SSF48498. SSF48498. 1 hit.
    PROSITEiPS01081. HTH_TETR_1. 1 hit.
    PS50977. HTH_TETR_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q1R4V1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPPGKCLFSG VFCNMAEKQT AKRNRREEIL QSLALMLESS DGSQRITTAK    50
    LAASVGVSEA ALYRHFPSKT RMFDSLIEFI EDSLITRINL ILKDEKDTTA 100
    RLRLIVLLLL GFGERNPGLT RILTGHALMF EQDRLQGRIN QLFERIEAQL 150
    RQVLREKRMR EGEGYATDET LLASQILAFC EGMLSRFVRS EFKYRPTDDF 200
    DARWPLIAAQ LQ 212
    Length:212
    Mass (Da):24,288
    Last modified:May 16, 2006 - v1
    Checksum:i378A696615488F38
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000243 Genomic DNA. Translation: ABE09613.1.
    RefSeqiYP_543144.2. NC_007946.1.

    Genome annotation databases

    EnsemblBacteriaiABE09613; ABE09613; UTI89_C4185.
    GeneIDi3991319.
    KEGGieci:UTI89_C4185.
    PATRICi18457790. VBIEscCol42261_4092.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000243 Genomic DNA. Translation: ABE09613.1 .
    RefSeqi YP_543144.2. NC_007946.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4GCL X-ray 2.65 A/B/C/D/E/F/G/H 1-212 [» ]
    ProteinModelPortali Q1R4V1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 364106.UTI89_C4185.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABE09613 ; ABE09613 ; UTI89_C4185 .
    GeneIDi 3991319.
    KEGGi eci:UTI89_C4185.
    PATRICi 18457790. VBIEscCol42261_4092.

    Phylogenomic databases

    eggNOGi COG1309.
    HOGENOMi HOG000266053.
    KOi K05501.
    OMAi EKDTSAR.
    OrthoDBi EOG6G7R3C.

    Enzyme and pathway databases

    BioCyci ECOL364106:GHPQ-4147-MONOMER.

    Family and domain databases

    Gene3Di 1.10.357.10. 1 hit.
    HAMAPi MF_01839. NO_factor_SlmA.
    InterProi IPR023772. DNA-bd_HTH_TetR-type_CS.
    IPR009057. Homeodomain-like.
    IPR001647. HTH_TetR.
    IPR023769. NO_SlmA.
    IPR015893. Tet_transcr_reg_TetR-like_C.
    IPR011075. Tet_transcr_reg_TetR-rel_C.
    [Graphical view ]
    Pfami PF00440. TetR_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    SSF48498. SSF48498. 1 hit.
    PROSITEi PS01081. HTH_TETR_1. 1 hit.
    PS50977. HTH_TETR_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of genes subject to positive selection in uropathogenic strains of Escherichia coli: a comparative genomics approach."
      Chen S.L., Hung C.-S., Xu J., Reigstad C.S., Magrini V., Sabo A., Blasiar D., Bieri T., Meyer R.R., Ozersky P., Armstrong J.R., Fulton R.S., Latreille J.P., Spieth J., Hooton T.M., Mardis E.R., Hultgren S.J., Gordon J.I.
      Proc. Natl. Acad. Sci. U.S.A. 103:5977-5982(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: UTI89 / UPECImported.
    2. "SlmA forms a higher-order structure on DNA that inhibits cytokinetic Z-ring formation over the nucleoid."
      Tonthat N.K., Milam S.L., Chinnam N., Whitfill T., Margolin W., Schumacher M.A.
      Proc. Natl. Acad. Sci. U.S.A. 110:10586-10591(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.65 ANGSTROMS).

    Entry informationi

    Entry nameiQ1R4V1_ECOUT
    AccessioniPrimary (citable) accession number: Q1R4V1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 16, 2006
    Last sequence update: May 16, 2006
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteomeImported

    External Data

    Dasty 3