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Protein

Nucleoid occlusion factor SlmA

Gene

ttk

Organism
Escherichia coli (strain UTI89 / UPEC)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions.UniRule annotationSAAS annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi47 – 66H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingUniRule annotationSAAS annotation
Biological processCell cycle, Cell divisionUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoid occlusion factor SlmAUniRule annotationSAAS annotation
Gene namesi
Name:ttkImported
Synonyms:slmAUniRule annotation
Ordered Locus Names:UTI89_C4185Imported
OrganismiEscherichia coli (strain UTI89 / UPEC)Imported
Taxonomic identifieri364106 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000001952 Componenti: Chromosome

Subcellular locationi

  • nucleoid SAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homodimer. Interacts with FtsZ.SAAS annotation

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4GCLX-ray2.65A/B/C/D/E/F/G/H1-212[»]
ProteinModelPortaliQ1R4V1
SMRiQ1R4V1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 84HTH tetR-typeInterPro annotationAdd BLAST61

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili132 – 152Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the nucleoid occlusion factor SlmA family.UniRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

HOGENOMiHOG000266053
KOiK05501
OMAiIEQTVFG

Family and domain databases

HAMAPiMF_01839 NO_factor_SlmA, 1 hit
InterProiView protein in InterPro
IPR023772 DNA-bd_HTH_TetR-type_CS
IPR009057 Homeobox-like_sf
IPR001647 HTH_TetR
IPR023769 NO_SlmA
IPR036271 Tet_transcr_reg_TetR-rel_C_sf
PfamiView protein in Pfam
PF00440 TetR_N, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
SSF48498 SSF48498, 1 hit
PROSITEiView protein in PROSITE
PS01081 HTH_TETR_1, 1 hit
PS50977 HTH_TETR_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q1R4V1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPGKCLFSG VFCNMAEKQT AKRNRREEIL QSLALMLESS DGSQRITTAK
60 70 80 90 100
LAASVGVSEA ALYRHFPSKT RMFDSLIEFI EDSLITRINL ILKDEKDTTA
110 120 130 140 150
RLRLIVLLLL GFGERNPGLT RILTGHALMF EQDRLQGRIN QLFERIEAQL
160 170 180 190 200
RQVLREKRMR EGEGYATDET LLASQILAFC EGMLSRFVRS EFKYRPTDDF
210
DARWPLIAAQ LQ
Length:212
Mass (Da):24,288
Last modified:May 16, 2006 - v1
Checksum:i378A696615488F38
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000243 Genomic DNA Translation: ABE09613.1

Genome annotation databases

EnsemblBacteriaiABE09613; ABE09613; UTI89_C4185
KEGGieci:UTI89_C4185

Similar proteinsi

Entry informationi

Entry nameiQ1R4V1_ECOUT
AccessioniPrimary (citable) accession number: Q1R4V1
Entry historyiIntegrated into UniProtKB/TrEMBL: May 16, 2006
Last sequence update: May 16, 2006
Last modified: March 28, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteomeImported
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Main funding by: National Institutes of Health