Reviewed, UniProtKB/Swiss-Prot Q1R4R6 (ADEC_ECOUT)

Names and origin

Protein names

Recommended name:
    Adenine deaminase
      Short name=Adenase
      Short name=Adenine aminase
    EC=3.5.4.2

Gene names

Name:	ade
Ordered Locus Names:	UTI89_C4221

Organism

Escherichia coli (strain UTI89 / UPEC) [Complete proteome] [HAMAP]

Taxonomic identifier

364106 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length	588 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Adenine + H2O = hypoxanthine + NH3. HAMAP MF_01518
Cofactor	Manganese By similarity.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the adenine deaminase family.

Ontologies

Keywords
Ligand	Manganese
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	adenine catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	adenine deaminase activity Inferred from electronic annotation. Source: HAMAP manganese ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 588	588	Adenine deaminase HAMAP MF_01518		PRO_0000296723

Sequences

	Sequence		Length	Mass (Da)
	Q1R4R6-1 [UniParc]. Last modified May 16, 2006. Version 1. Checksum: EF00812CDD92F402	FASTA	588	63,851
	10 20 30 40 50 60 MNNSINHKFH HISRTEYQEL LAVSRGDAVA DYIIDNVSIL DLINGGEISG PIVIKGRYIA 70 80 90 100 110 120 GVGAEYADAP ALQRIDARGA TAVPGFIDAH LHIESSMMTP VTFETATLPR GLTTVICDPH 130 140 150 160 170 180 EIVNVMGEAG FAWFARCAEQ ARQNQYLQVS SCVPALEGCD VNGASFTLEQ MLAWRDHPQV 190 200 210 220 230 240 TGLAEMMDYP GVISGQNALL DKLDAFRHLT LDGHCPGLGG KELNAYIAAG IENCHESYQL 250 260 270 280 290 300 EEGRRKLQLG MSLMIREGSA ARNLNALAPL INEFNSPQCM LCTDDRNPWE IAHEGHIDAL 310 320 330 340 350 360 IRRLIEQHNV PLHVAYRVAS WSTARHFGLN HLGLLAPGKQ ADIVLLSDAR KVTVQQVLVK 370 380 390 400 410 420 GEPIDAQTLQ AEESARLAQS APPYGNTIDR QPVSASDFAL QFTPGKRYRV IEVIHNELIT 430 440 450 460 470 480 HSRSSVYSEN GFDRDDVCFI AVLERYGQRL APACGLLGGF GLNEGALAAT VSHDSHNIVV 490 500 510 520 530 540 IGRSAEEMAL AVNQVIQDGG GLCVVRNGQV QSHLPLPIAG LMSTDTAQSL AEQIDALKAA 550 560 570 580 ARECGPLPDE PFIQMAFLSL PVIPALKLTS QGLFDGEKFA FTTLEFTE

References

[1]

"Identification of genes subject to positive selection in uropathogenic strains of Escherichia coli: a comparative genomics approach." Chen S.L., Hung C.-S., Xu J., Reigstad C.S., Magrini V., Sabo A., Blasiar D., Bieri T., Meyer R.R., Ozersky P., Armstrong J.R., Fulton R.S., Latreille J.P., Spieth J., Hooton T.M., Mardis E.R., Hultgren S.J., Gordon J.I. Proc. Natl. Acad. Sci. U.S.A. 103:5977-5982(2006) [PubMed: 16585510] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000243 Genomic DNA. Translation: ABE09648.1.
RefSeq	YP_543179.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3991498.
GenomeReviews	Gene locus UTI89_C4221 in contig CP000243_GR.
KEGG	eci:UTI89_C4221.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q1R4R6.
OMA	Q1R4R6. IMIREGS.
Enzyme and pathway databases
BioCyc	ECOL364106:UTI89_C4221-MON.
Family and domain databases
HAMAP	MF_01518. [Tree]
InterPro	IPR006679. Adenine_deam. IPR006680. Amidohydro_1. [Graphical view]
Pfam	PF01979. Amidohydro_1. 1 hit. [Graphical view]
TIGRFAMs	TIGR01178. ade. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ADEC_ECOUT

Accession

Primary (citable) accession number: Q1R4R6

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 24, 2007
Last sequence update:	May 16, 2006
Last modified:	May 5, 2009
This is version 18 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)