Reviewed, UniProtKB/Swiss-Prot Q1R3P7 (UBIC_ECOUT)

Names and origin

Protein names

Recommended name:
    Chorismate--pyruvate lyase
      Short name=CL
      Short name=CPL
    EC=4.1.3.40

Gene names

Name:	ubiC
Ordered Locus Names:	UTI89_C4609

Organism

Escherichia coli (strain UTI89 / UPEC) [Complete proteome] [HAMAP]

Taxonomic identifier

364106 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length	165 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway By similarity. HAMAP MF_01632
Catalytic activity	Chorismate = 4-hydroxybenzoate + pyruvate. HAMAP MF_01632
Pathway	Cofactor biosynthesis; ubiquinone biosynthesis. HAMAP MF_01632
Subunit structure	Monomer By similarity. HAMAP MF_01632
Subcellular location	Cytoplasm By similarity HAMAP MF_01632.
Sequence similarities	Belongs to the ubiC family.

Ontologies

Keywords
Biological process	Ubiquinone biosynthesis
Cellular component	Cytoplasm
Ligand	Pyruvate
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	pyruvate biosynthetic process Inferred from electronic annotation. Source: HAMAP ubiquinone biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	chorismate lyase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 165	165	Chorismate--pyruvate lyase HAMAP MF_01632		PRO_0000255907
Sites
	Binding site	35	1	Substrate; via amide nitrogen By similarity
	Binding site	77	1	Substrate By similarity
	Binding site	115	1	Substrate; via amide nitrogen By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q1R3P7-1 [UniParc]. Last modified May 16, 2006. Version 1. Checksum: 7705434B48859FB6	FASTA	165	18,808
	10 20 30 40 50 60 MSHPALTQLR ALRYFTEIPA LEPQLLDWLL LEDSMTKRFE QQGKTVSVTM IREGFVEQNE 70 80 90 100 110 120 IPEELPLLPK ESRYWLREIL LCADGEPWLA GRTVVPVSTL SGPELALQKL GKTPLGRYLF 130 140 150 160 TSSTLTRDFI EIGRDAGLWG RRSRLRLSGK PLLLTELFLP ASPLY

References

[1]

"Identification of genes subject to positive selection in uropathogenic strains of Escherichia coli: a comparative genomics approach." Chen S.L., Hung C.-S., Xu J., Reigstad C.S., Magrini V., Sabo A., Blasiar D., Bieri T., Meyer R.R., Ozersky P., Armstrong J.R., Fulton R.S., Latreille J.P., Spieth J., Hooton T.M., Mardis E.R., Hultgren S.J., Gordon J.I. Proc. Natl. Acad. Sci. U.S.A. 103:5977-5982(2006) [PubMed: 16585510] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000243 Genomic DNA. Translation: ABE10017.1.
RefSeq	YP_543548.1.
3D structure databases
SMR	Q1R3P7. Positions 2-165.
ModBase	Search...
Protein-protein interaction databases
STRING	Q1R3P7.
Genome annotation databases
GeneID	3991086.
GenomeReviews	Gene locus UTI89_C4609 in contig CP000243_GR.
KEGG	eci:UTI89_C4609.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG3161.
HOGENOM	HBG644467.
OMA	QPWVFAR.
Enzyme and pathway databases
BioCyc	ECOL364106:UTI89_C4609-MONOMER.
Family and domain databases
HAMAP	MF_01632. UbiC. [Tree]
InterPro	IPR007440. Chorismate--pyruvate_lyase. [Graphical view]
Pfam	PF04345. Chor_lyase. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UBIC_ECOUT

Accession

Primary (citable) accession number: Q1R3P7

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	May 16, 2006
Last modified:	January 19, 2010
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)