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Reviewed, UniProtKB/Swiss-Prot Q1R3P7 (UBIC_ECOUT)

Last modified January 19, 2010. Version 27. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Chorismate--pyruvate lyase
      Short name=CL
      Short name=CPL
    EC=4.1.3.40
Gene names
Name: ubiC
Ordered Locus Names: UTI89_C4609
OrganismEscherichia coli (strain UTI89 / UPEC) [Complete proteome] [HAMAP]
Taxonomic identifier364106 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Protein attributes

Sequence length165 AA.
Sequence statusComplete.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway By similarity. HAMAP MF_01632

Catalytic activity

Chorismate = 4-hydroxybenzoate + pyruvate. HAMAP MF_01632

Pathway

Cofactor biosynthesis; ubiquinone biosynthesis. HAMAP MF_01632

Subunit structure

Monomer By similarity. HAMAP MF_01632

Subcellular location

Cytoplasm By similarity HAMAP MF_01632.

Sequence similarities

Belongs to the ubiC family.

Ontologies

Keywords
   Biological processUbiquinone biosynthesis
   Cellular componentCytoplasm
   LigandPyruvate
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processpyruvate biosynthetic process

Inferred from electronic annotation. Source: HAMAP

ubiquinone biosynthetic process

Inferred from electronic annotation. Source: HAMAP

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionchorismate lyase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 165165Chorismate--pyruvate lyase HAMAP MF_01632
PRO_0000255907

Sites

Binding site351Substrate; via amide nitrogen By similarity
Binding site771Substrate By similarity
Binding site1151Substrate; via amide nitrogen By similarity

Sequences

Sequence LengthMass (Da)Tools
Q1R3P7-1 [UniParc].

Last modified May 16, 2006. Version 1.
Checksum: 7705434B48859FB6

FASTA16518,808
        10         20         30         40         50         60 
MSHPALTQLR ALRYFTEIPA LEPQLLDWLL LEDSMTKRFE QQGKTVSVTM IREGFVEQNE 

        70         80         90        100        110        120 
IPEELPLLPK ESRYWLREIL LCADGEPWLA GRTVVPVSTL SGPELALQKL GKTPLGRYLF 

       130        140        150        160 
TSSTLTRDFI EIGRDAGLWG RRSRLRLSGK PLLLTELFLP ASPLY 

« Hide

References

[1]"Identification of genes subject to positive selection in uropathogenic strains of Escherichia coli: a comparative genomics approach."
Chen S.L., Hung C.-S., Xu J., Reigstad C.S., Magrini V., Sabo A., Blasiar D., Bieri T., Meyer R.R., Ozersky P., Armstrong J.R., Fulton R.S., Latreille J.P., Spieth J., Hooton T.M., Mardis E.R., Hultgren S.J., Gordon J.I.
Proc. Natl. Acad. Sci. U.S.A. 103:5977-5982(2006) [PubMed: 16585510] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000243 Genomic DNA. Translation: ABE10017.1.
RefSeqYP_543548.1.

3D structure databases

SMRQ1R3P7. Positions 2-165.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ1R3P7.

Genome annotation databases

GeneID3991086.
GenomeReviewsGene locus UTI89_C4609 in contig CP000243_GR.
KEGGeci:UTI89_C4609.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG3161.
HOGENOMHBG644467.
OMAQPWVFAR.

Enzyme and pathway databases

BioCycECOL364106:UTI89_C4609-MONOMER.

Family and domain databases

HAMAPMF_01632. UbiC.
[Tree]
InterProIPR007440. Chorismate--pyruvate_lyase.
[Graphical view]
PfamPF04345. Chor_lyase. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUBIC_ECOUT
AccessionPrimary (citable) accession number: Q1R3P7
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: May 16, 2006
Last modified: January 19, 2010
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents