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Q1R3B6

- CH60_ECOUT

UniProt

Q1R3B6 - CH60_ECOUT

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Protein

60 kDa chaperonin

Gene
groL, groEL, UTI89_C4741
Organism
Escherichia coli (strain UTI89 / UPEC)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions By similarity.UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. protein refolding Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciECOL364106:GHPQ-4694-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
60 kDa chaperonin
Alternative name(s):
GroEL protein
Protein Cpn60
Gene namesi
Name:groL
Synonyms:groEL
Ordered Locus Names:UTI89_C4741
OrganismiEscherichia coli (strain UTI89 / UPEC)
Taxonomic identifieri364106 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000001952: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 54854860 kDa chaperoninUniRule annotationPRO_0000256909Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei117 – 1171N6-acetyllysine By similarity

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiQ1R3B6.

Interactioni

Subunit structurei

Oligomer of 14 subunits composed of two stacked rings of 7 subunits By similarity.

Protein-protein interaction databases

DIPiDIP-59993N.
STRINGi364106.UTI89_C4741.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2YNJelectron microscopy8.40A/B/C/D/E/F/G/H/I/J/K/L/M/N2-525[»]
3E76X-ray3.94A/B/C/D/E/F/G/H/I/J/K/L/M/N2-548[»]
ProteinModelPortaliQ1R3B6.

Miscellaneous databases

EvolutionaryTraceiQ1R3B6.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0459.
HOGENOMiHOG000076290.
KOiK04077.
OMAiVLFGNDA.
OrthoDBiEOG6JDWBZ.

Family and domain databases

Gene3Di1.10.560.10. 2 hits.
3.50.7.10. 1 hit.
HAMAPiMF_00600. CH60.
InterProiIPR018370. Chaperonin_Cpn60_CS.
IPR001844. Chaprnin_Cpn60.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
[Graphical view]
PANTHERiPTHR11353. PTHR11353. 1 hit.
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00298. CHAPERONIN60.
SUPFAMiSSF48592. SSF48592. 2 hits.
SSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02348. GroEL. 1 hit.
PROSITEiPS00296. CHAPERONINS_CPN60. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1R3B6-1 [UniParc]FASTAAdd to Basket

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MAAKDVKFGN DARVKMLRGV NVLADAVKVT LGPKGRNVVL DKSFGAPTIT    50
KDGVSVAREI ELEDKFENMG AQMVKEVASK ANDAAGDGTT TATVLAQAII 100
TEGLKAVAAG MNPMDLKRGI DKAVTAAVEE LKALSVPCSD SKAIAQVGTI 150
SANSDETVGK LIAEAMDKVG KEGVITVEDG TGLQDELDVV EGMQFDRGYL 200
SPYFINKPET GAVELESPFI LLADKKISNI REMLPVLEAV AKAGKPLLII 250
AEDVEGEALA TLVVNTMRGI VKVAAVKAPG FGDRRKAMLQ DIATLTGGTV 300
ISEEIGMELE KATLEDLGQA KRVVINKDTT TIIDGVGEEA AIQGRVAQIR 350
QQIEEATSDY DREKLQERVA KLAGGVAVIK VGAATEVEMK EKKARVEDAL 400
HATRAAVEEG VVAGGGVALI RVASKLADLR GQNEDQNVGI KVALRAMEAP 450
LRQIVLNCGE EPSVVANTVK GGDGNYGYNA ATEEYGNMID MGILDPTKVT 500
RSALQYAASV AGLMITTECM VTDLPKNDAA DLGAAGGMGG MGGMGGMM 548
Length:548
Mass (Da):57,329
Last modified:May 16, 2006 - v1
Checksum:iCD3A0FB505F74AD1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000243 Genomic DNA. Translation: ABE10148.1.
RefSeqiYP_543679.1. NC_007946.1.

Genome annotation databases

EnsemblBacteriaiABE10148; ABE10148; UTI89_C4741.
GeneIDi3991044.
KEGGieci:UTI89_C4741.
PATRICi18458884. VBIEscCol42261_4618.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000243 Genomic DNA. Translation: ABE10148.1 .
RefSeqi YP_543679.1. NC_007946.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2YNJ electron microscopy 8.40 A/B/C/D/E/F/G/H/I/J/K/L/M/N 2-525 [» ]
3E76 X-ray 3.94 A/B/C/D/E/F/G/H/I/J/K/L/M/N 2-548 [» ]
ProteinModelPortali Q1R3B6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-59993N.
STRINGi 364106.UTI89_C4741.

Proteomic databases

PRIDEi Q1R3B6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABE10148 ; ABE10148 ; UTI89_C4741 .
GeneIDi 3991044.
KEGGi eci:UTI89_C4741.
PATRICi 18458884. VBIEscCol42261_4618.

Phylogenomic databases

eggNOGi COG0459.
HOGENOMi HOG000076290.
KOi K04077.
OMAi VLFGNDA.
OrthoDBi EOG6JDWBZ.

Enzyme and pathway databases

BioCyci ECOL364106:GHPQ-4694-MONOMER.

Miscellaneous databases

EvolutionaryTracei Q1R3B6.

Family and domain databases

Gene3Di 1.10.560.10. 2 hits.
3.50.7.10. 1 hit.
HAMAPi MF_00600. CH60.
InterProi IPR018370. Chaperonin_Cpn60_CS.
IPR001844. Chaprnin_Cpn60.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
[Graphical view ]
PANTHERi PTHR11353. PTHR11353. 1 hit.
Pfami PF00118. Cpn60_TCP1. 1 hit.
[Graphical view ]
PRINTSi PR00298. CHAPERONIN60.
SUPFAMi SSF48592. SSF48592. 2 hits.
SSF52029. SSF52029. 1 hit.
TIGRFAMsi TIGR02348. GroEL. 1 hit.
PROSITEi PS00296. CHAPERONINS_CPN60. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Identification of genes subject to positive selection in uropathogenic strains of Escherichia coli: a comparative genomics approach."
    Chen S.L., Hung C.-S., Xu J., Reigstad C.S., Magrini V., Sabo A., Blasiar D., Bieri T., Meyer R.R., Ozersky P., Armstrong J.R., Fulton R.S., Latreille J.P., Spieth J., Hooton T.M., Mardis E.R., Hultgren S.J., Gordon J.I.
    Proc. Natl. Acad. Sci. U.S.A. 103:5977-5982(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: UTI89 / UPEC.

Entry informationi

Entry nameiCH60_ECOUT
AccessioniPrimary (citable) accession number: Q1R3B6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: May 16, 2006
Last modified: June 11, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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