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Q1R3B6

- CH60_ECOUT

UniProt

Q1R3B6 - CH60_ECOUT

Protein

60 kDa chaperonin

Gene

groL

Organism
Escherichia coli (strain UTI89 / UPEC)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 56 (01 Oct 2014)
      Sequence version 1 (16 May 2006)
      Previous versions | rss
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    Functioni

    Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.UniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. protein refolding Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Chaperone

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciECOL364106:GHPQ-4694-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    60 kDa chaperoninUniRule annotation
    Alternative name(s):
    GroEL proteinUniRule annotation
    Protein Cpn60UniRule annotation
    Gene namesi
    Name:groLUniRule annotation
    Synonyms:groELUniRule annotation
    Ordered Locus Names:UTI89_C4741
    OrganismiEscherichia coli (strain UTI89 / UPEC)
    Taxonomic identifieri364106 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000001952: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 54854860 kDa chaperoninPRO_0000256909Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei117 – 1171N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PRIDEiQ1R3B6.

    Interactioni

    Subunit structurei

    Oligomer of 14 subunits composed of two stacked rings of 7 subunits.UniRule annotation

    Protein-protein interaction databases

    DIPiDIP-59993N.
    STRINGi364106.UTI89_C4741.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2YNJelectron microscopy8.40A/B/C/D/E/F/G/H/I/J/K/L/M/N2-525[»]
    3E76X-ray3.94A/B/C/D/E/F/G/H/I/J/K/L/M/N2-548[»]
    ProteinModelPortaliQ1R3B6.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ1R3B6.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the chaperonin (HSP60) family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0459.
    HOGENOMiHOG000076290.
    KOiK04077.
    OMAiVLFGNDA.
    OrthoDBiEOG6JDWBZ.

    Family and domain databases

    Gene3Di1.10.560.10. 2 hits.
    3.50.7.10. 1 hit.
    HAMAPiMF_00600. CH60.
    InterProiIPR018370. Chaperonin_Cpn60_CS.
    IPR001844. Chaprnin_Cpn60.
    IPR002423. Cpn60/TCP-1.
    IPR027409. GroEL-like_apical_dom.
    IPR027413. GROEL-like_equatorial.
    [Graphical view]
    PANTHERiPTHR11353. PTHR11353. 1 hit.
    PfamiPF00118. Cpn60_TCP1. 1 hit.
    [Graphical view]
    PRINTSiPR00298. CHAPERONIN60.
    SUPFAMiSSF48592. SSF48592. 2 hits.
    SSF52029. SSF52029. 1 hit.
    TIGRFAMsiTIGR02348. GroEL. 1 hit.
    PROSITEiPS00296. CHAPERONINS_CPN60. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q1R3B6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAKDVKFGN DARVKMLRGV NVLADAVKVT LGPKGRNVVL DKSFGAPTIT    50
    KDGVSVAREI ELEDKFENMG AQMVKEVASK ANDAAGDGTT TATVLAQAII 100
    TEGLKAVAAG MNPMDLKRGI DKAVTAAVEE LKALSVPCSD SKAIAQVGTI 150
    SANSDETVGK LIAEAMDKVG KEGVITVEDG TGLQDELDVV EGMQFDRGYL 200
    SPYFINKPET GAVELESPFI LLADKKISNI REMLPVLEAV AKAGKPLLII 250
    AEDVEGEALA TLVVNTMRGI VKVAAVKAPG FGDRRKAMLQ DIATLTGGTV 300
    ISEEIGMELE KATLEDLGQA KRVVINKDTT TIIDGVGEEA AIQGRVAQIR 350
    QQIEEATSDY DREKLQERVA KLAGGVAVIK VGAATEVEMK EKKARVEDAL 400
    HATRAAVEEG VVAGGGVALI RVASKLADLR GQNEDQNVGI KVALRAMEAP 450
    LRQIVLNCGE EPSVVANTVK GGDGNYGYNA ATEEYGNMID MGILDPTKVT 500
    RSALQYAASV AGLMITTECM VTDLPKNDAA DLGAAGGMGG MGGMGGMM 548
    Length:548
    Mass (Da):57,329
    Last modified:May 16, 2006 - v1
    Checksum:iCD3A0FB505F74AD1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000243 Genomic DNA. Translation: ABE10148.1.
    RefSeqiYP_543679.1. NC_007946.1.

    Genome annotation databases

    EnsemblBacteriaiABE10148; ABE10148; UTI89_C4741.
    GeneIDi3991044.
    KEGGieci:UTI89_C4741.
    PATRICi18458884. VBIEscCol42261_4618.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000243 Genomic DNA. Translation: ABE10148.1 .
    RefSeqi YP_543679.1. NC_007946.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2YNJ electron microscopy 8.40 A/B/C/D/E/F/G/H/I/J/K/L/M/N 2-525 [» ]
    3E76 X-ray 3.94 A/B/C/D/E/F/G/H/I/J/K/L/M/N 2-548 [» ]
    ProteinModelPortali Q1R3B6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-59993N.
    STRINGi 364106.UTI89_C4741.

    Proteomic databases

    PRIDEi Q1R3B6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABE10148 ; ABE10148 ; UTI89_C4741 .
    GeneIDi 3991044.
    KEGGi eci:UTI89_C4741.
    PATRICi 18458884. VBIEscCol42261_4618.

    Phylogenomic databases

    eggNOGi COG0459.
    HOGENOMi HOG000076290.
    KOi K04077.
    OMAi VLFGNDA.
    OrthoDBi EOG6JDWBZ.

    Enzyme and pathway databases

    BioCyci ECOL364106:GHPQ-4694-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei Q1R3B6.

    Family and domain databases

    Gene3Di 1.10.560.10. 2 hits.
    3.50.7.10. 1 hit.
    HAMAPi MF_00600. CH60.
    InterProi IPR018370. Chaperonin_Cpn60_CS.
    IPR001844. Chaprnin_Cpn60.
    IPR002423. Cpn60/TCP-1.
    IPR027409. GroEL-like_apical_dom.
    IPR027413. GROEL-like_equatorial.
    [Graphical view ]
    PANTHERi PTHR11353. PTHR11353. 1 hit.
    Pfami PF00118. Cpn60_TCP1. 1 hit.
    [Graphical view ]
    PRINTSi PR00298. CHAPERONIN60.
    SUPFAMi SSF48592. SSF48592. 2 hits.
    SSF52029. SSF52029. 1 hit.
    TIGRFAMsi TIGR02348. GroEL. 1 hit.
    PROSITEi PS00296. CHAPERONINS_CPN60. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of genes subject to positive selection in uropathogenic strains of Escherichia coli: a comparative genomics approach."
      Chen S.L., Hung C.-S., Xu J., Reigstad C.S., Magrini V., Sabo A., Blasiar D., Bieri T., Meyer R.R., Ozersky P., Armstrong J.R., Fulton R.S., Latreille J.P., Spieth J., Hooton T.M., Mardis E.R., Hultgren S.J., Gordon J.I.
      Proc. Natl. Acad. Sci. U.S.A. 103:5977-5982(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: UTI89 / UPEC.

    Entry informationi

    Entry nameiCH60_ECOUT
    AccessioniPrimary (citable) accession number: Q1R3B6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: May 16, 2006
    Last modified: October 1, 2014
    This is version 56 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3