Reviewed, UniProtKB/Swiss-Prot Q1R2Q6 (SDHD2_ECOUT)

Names and origin

Protein names

Recommended name:
    D-serine dehydratase 2
    EC=4.3.1.18
Alternative name(s):
    D-serine deaminase 2
      Short name=DSD 2

Gene names

Name:	dsdA2
Ordered Locus Names:	UTI89_C4955

Organism

Escherichia coli (strain UTI89 / UPEC) [Complete proteome] [HAMAP]

Taxonomic identifier

364106 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length	442 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-serine = pyruvate + NH3. HAMAP MF_01030
Cofactor	Pyridoxal phosphate By similarity.
Subunit structure	Monomer By similarity.
Sequence similarities	Belongs to the serine/threonine dehydratase family. DsdA subfamily.

Ontologies

Keywords
Ligand	Pyridoxal phosphate
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	D-amino acid metabolic process Inferred from electronic annotation. Source: HAMAP
Molecular function	D-serine ammonia-lyase activity Inferred from electronic annotation. Source: EC hydro-lyase activity Inferred from electronic annotation. Source: HAMAP pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 442	442	D-serine dehydratase 2 HAMAP MF_01030		PRO_0000291727
Amino acid modifications
	Modified residue	118	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q1R2Q6-1 [UniParc]. Last modified May 16, 2006. Version 1. Checksum: 9EE4AFA3FCC96D7F	FASTA	442	47,881
	10 20 30 40 50 60 MENAKMNSLI AQYPLVKDLV ALKETTWFNP GTTSLAEGLP YVGLTEQDVQ DAHARLSRFA 70 80 90 100 110 120 PYLAKAFPET AATGGIIESE LVAIPAMQKR LEKEYQQPIS GQLLLKKDSH LPISGSIKAR 130 140 150 160 170 180 GGIYEVLAHA EKLALEAGLL TLEDDYSKLL SPEFKQFFSQ YSIAVGSTGN LGLSIGIMSA 190 200 210 220 230 240 RIGFKVTVHM SADARAWKKA KLRSHGVTVV EYEQDYGVAV EEGRKAAQSD PNCFFIDDEN 250 260 270 280 290 300 SRTLFLGYSV AGQRLKAQFA QQGRIVDADN PLFVYLPCGV GGGPGGVAFG LKLAFGDHVH 310 320 330 340 350 360 CFFAEPTHSP CMLLGVHTGL HDQISVQDIG IDNLTAADGL AVGRASGFVG RAMERLLDGF 370 380 390 400 410 420 YTLSDQTMYD MLGWLAQEEG IRLEPSALAG MAGPQRVCAS VSYQQMHGFS AEQLRNATHL 430 440 VWATGGGMVP EEEMEQYLAK GH

References

[1]

"Identification of genes subject to positive selection in uropathogenic strains of Escherichia coli: a comparative genomics approach." Chen S.L., Hung C.-S., Xu J., Reigstad C.S., Magrini V., Sabo A., Blasiar D., Bieri T., Meyer R.R., Ozersky P., Armstrong J.R., Fulton R.S., Latreille J.P., Spieth J., Hooton T.M., Mardis E.R., Hultgren S.J., Gordon J.I. Proc. Natl. Acad. Sci. U.S.A. 103:5977-5982(2006) [PubMed: 16585510] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000243 Genomic DNA. Translation: ABE10358.1.
RefSeq	YP_543889.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3990843.
GenomeReviews	Gene locus UTI89_C4955 in contig CP000243_GR.
KEGG	eci:UTI89_C4955.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q1R2Q6.
OMA	Q1R2Q6. DHPLFVY.
Enzyme and pathway databases
BioCyc	ECOL364106:UTI89_C4955-MON.
Family and domain databases
HAMAP	MF_01030. [Tree]
InterPro	IPR011780. D_Ser_am_lyase. IPR001926. PyrdxlP-dep_enz_bsu. IPR000634. Ser/Thr_deHydtase_PyrdxlP-BS. [Graphical view]
PANTHER	PTHR10314:SF9. D_Ser_am_lyase. 1 hit.
Pfam	PF00291. PALP. 1 hit. [Graphical view]
TIGRFAMs	TIGR02035. D_Ser_am_lyase. 1 hit.
PROSITE	PS00165. DEHYDRATASE_SER_THR. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SDHD2_ECOUT

Accession

Primary (citable) accession number: Q1R2Q6

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 26, 2007
Last sequence update:	May 16, 2006
Last modified:	June 16, 2009
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)