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Reviewed, UniProtKB/Swiss-Prot Q1R1N5 (HLDD_CHRSD)

Last modified June 16, 2009. Version 25. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    ADP-L-glycero-D-manno-heptose-6-epimerase
    EC=5.1.3.20
Alternative name(s):
    ADP-L-glycero-beta-D-manno-heptose-6-epimerase
      Short name=ADP-glyceromanno-heptose 6-epimerase
      Short name=ADP-hep 6-epimerase
      Short name=AGME
Gene names
Name: hldD
Ordered Locus Names: Csal_0008
OrganismChromohalobacter salexigens (strain DSM 3043 / ATCC BAA-138 / NCIMB 13768) [Complete proteome] [HAMAP]
Taxonomic identifier290398 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Oceanospirillales › Halomonadaceae › Chromohalobacter

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Protein attributes

Sequence length318 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

Catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose By similarity.

Catalytic activity

ADP-D-glycero-D-manno-heptose = ADP-L-glycero-D-manno-heptose. HAMAP MF_01601

Cofactor

Binds 1 NADP+ per subunit By similarity.

Pathway

Nucleotide-sugar biosynthesis; ADP-L-glycero-beta-D-manno-heptose biosynthesis; ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate: step 4/4. HAMAP MF_01601

Subunit structure

Homopentamer By similarity.

Domain

Contains a large N-terminal NADP-binding domain, and a smaller C-terminal substrate-binding domain By similarity.

Sequence similarities

Belongs to the sugar epimerase family. HldD subfamily.

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Ontologies

Keywords
   Biological processCarbohydrate metabolism
   LigandNADP
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processcarbohydrate metabolic process

Inferred from electronic annotation. Source: HAMAP

cellular metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular functionADP-glyceromanno-heptose 6-epimerase activity

Inferred from electronic annotation. Source: HAMAP

NADP or NADPH binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 318318ADP-L-glycero-D-manno-heptose-6-epimerase HAMAP MF_01601
PRO_0000255726

Regions

Nucleotide binding10 – 112NADP By similarity
Nucleotide binding31 – 322NADP By similarity
Nucleotide binding80 – 845NADP By similarity
Region205 – 2084Substrate binding By similarity

Sites

Active site1441Proton acceptor By similarity
Active site1821Proton acceptor By similarity
Binding site381NADP By similarity
Binding site531NADP By similarity
Binding site971NADP By similarity
Binding site1481NADP By similarity
Binding site1731Substrate By similarity
Binding site1741NADP; via amide nitrogen By similarity
Binding site1821NADP By similarity
Binding site1841Substrate; via carbonyl oxygen By similarity
Binding site1911Substrate By similarity
Binding site2181Substrate By similarity
Binding site2821Substrate By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q1R1N5-1 [UniParc].

Last modified October 31, 2006. Version 2.
Checksum: D87EC102A8046625

FASTA31835,939
        10         20         30         40         50         60 
MIVVTGGAGF IGANLVKALN ARGREDVLVV DDLSDGTKFV NLADCTLGDY LDKDDFLARV 

        70         80         90        100        110        120 
KAELRGEPSE LPPIEAIFHE GACSDTTEWD GKFMLENNFE YSKVLLHFCQ YKRIPFLYAS 

       130        140        150        160        170        180 
SAATYGGSEV FVEAPEHEKP LNVYGYSKLL FDQYVRVHWE SFDAQVVGFR YFNVYGPREQ 

       190        200        210        220        230        240 
HKGKMASVAY HHHSQVKRGE NPKLFGAWDG YEAGMQSRDF VYVGDVVDVN LWCLDHPEVS 

       250        260        270        280        290        300 
GIFNLGTGRA EPFKAIAETV IDYYATGKID YIDFPEELKG RYQSYTRADI SRLREAGYKA 

       310 
EFKTVREGVS AYLDWLNG

« Hide

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References

[1]"Complete sequence of Chromohalobacter salexigens DSM 3043."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Saunders E., Schmutz J. expand/collapse author list , Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Csonka L.N., O'Conner K., Vreeland R.H., Oren A., Vargas C., Nieto J., Arahal D.R., Goodner B., Wheeler C., Hall P., Ewing A., Benson L., McBeath D., Canovas D., Richardson P.
Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

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Cross-references

Sequence databases

CP000285 Genomic DNA. Translation: ABE57373.1. Different initiation.
RefSeqYP_572072.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID4027327.
GenomeReviewsGene locus Csal_0008 in contig CP000285_GR.
KEGGcsa:Csal_0008.
NMPDRfig|290398.4.peg.150.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ1R1N5.

Enzyme and pathway databases

BioCycCSAL290398:CSAL_0008-MON.

Family and domain databases

HAMAPMF_01601.
[Tree]
InterProIPR001509. Epimerase_deHydtase.
IPR011912. Heptose_epim.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHERPTHR10366:SF29. Heptose_epim. 1 hit.
PfamPF01370. Epimerase. 1 hit.
[Graphical view]
TIGRFAMsTIGR02197. heptose_epim. 1 hit.
ProtoNetSearch...

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Entry information

Entry nameHLDD_CHRSD
AccessionPrimary (citable) accession number: Q1R1N5
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 31, 2006
Last modified: June 16, 2009
This is version 25 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents