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Reviewed, UniProtKB/Swiss-Prot Q1R1C8 (DCUP_CHRSD)

Last modified June 16, 2009. Version 27. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Uroporphyrinogen decarboxylase
      Short name=URO-D
      Short name=UPD
    EC=4.1.1.37
Gene names
Name: hemE
Ordered Locus Names: Csal_0116
OrganismChromohalobacter salexigens (strain DSM 3043 / ATCC BAA-138 / NCIMB 13768) [Complete proteome] [HAMAP]
Taxonomic identifier290398 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Oceanospirillales › Halomonadaceae › Chromohalobacter

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Protein attributes

Sequence length353 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III By similarity.

Catalytic activity

Uroporphyrinogen III = coproporphyrinogen + 4 CO2. HAMAP MF_00218

Pathway

Porphyrin metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4. HAMAP MF_00218

Subunit structure

Homodimer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the uroporphyrinogen decarboxylase family.

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Ontologies

Keywords
   Biological processPorphyrin biosynthesis
   Cellular componentCytoplasm
   Molecular functionDecarboxylase
Lyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processporphyrin biosynthetic process

Inferred from electronic annotation. Source: HAMAP

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionuroporphyrinogen decarboxylase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 353353Uroporphyrinogen decarboxylase HAMAP MF_00218
PRO_0000325633

Regions

Region26 – 305Substrate binding By similarity

Sites

Binding site761Substrate By similarity
Binding site1531Substrate By similarity
Binding site2081Substrate By similarity
Binding site3261Substrate By similarity
Site761Transition state stabilizer By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q1R1C8-1 [UniParc].

Last modified May 16, 2006. Version 1.
Checksum: 83C5FDBF155A9CEA

FASTA35339,041
        10         20         30         40         50         60 
MPLQNDRLLR ALARQPVDRT PVWMMRQAGR YLPEYRETRG QAGSFMDLCR NAELACEVTM 

        70         80         90        100        110        120 
QPLRRYALDA AILFSDILTI PDAMDLGLYF ETGEGPKFRK TVRSAEAVDA LPVPDAERDL 

       130        140        150        160        170        180 
DYVMNAVRTI RHELADSVPL IGFSGSPWTL ATYMIEGGSS KDFRHAKALM YGDPAAMHAL 

       190        200        210        220        230        240 
LDKLARSVTD YLNAQIRAGA QIVQIFDTWG GVLSTPAYRE FSLAYMARIV EGLIREHEGR 

       250        260        270        280        290        300 
HVPVILFTKQ GGQWLETIAD SGADAVGLDW TTELSDARAR VGDRVALQGN LDPNVLFASP 

       310        320        330        340        350 
QAIRDEVARI LASYGSGPGH VFNLGHGVSQ FTDPDHVAAF IEALHELSPR YHG

« Hide

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References

[1]"Complete sequence of Chromohalobacter salexigens DSM 3043."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Saunders E., Schmutz J. expand/collapse author list , Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Csonka L.N., O'Conner K., Vreeland R.H., Oren A., Vargas C., Nieto J., Arahal D.R., Goodner B., Wheeler C., Hall P., Ewing A., Benson L., McBeath D., Canovas D., Richardson P.
Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

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Cross-references

Sequence databases

CP000285 Genomic DNA. Translation: ABE57480.1.
RefSeqYP_572179.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID4027042.
GenomeReviewsGene locus Csal_0116 in contig CP000285_GR.
KEGGcsa:Csal_0116.
NMPDRfig|290398.4.peg.447.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ1R1C8.
OMAQ1R1C8. VFTKGGG.

Enzyme and pathway databases

BioCycCSAL290398:CSAL_0116-MON.

Family and domain databases

HAMAPMF_00218.
[Tree]
InterProIPR006361. Uroporphyrinogen_deCO2ase_HemE.
IPR000257. Uroporphyrinogen_deCOase.
[Graphical view]
PANTHERPTHR21091:SF2. HemE. 1 hit.
PfamPF01208. URO-D. 1 hit.
[Graphical view]
ProDomPD003225. Uro_decarbxyls. 1 hit.
[Graphical view] [Entries sharing at least one domain]
TIGRFAMsTIGR01464. hemE. 1 hit.
PROSITEPS00906. UROD_1. 1 hit.
PS00907. UROD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameDCUP_CHRSD
AccessionPrimary (citable) accession number: Q1R1C8
Entry history
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: May 16, 2006
Last modified: June 16, 2009
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents