Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Catalase-peroxidase

Gene

katG

Organism
Chromohalobacter salexigens (strain DSM 3043 / ATCC BAA-138 / NCIMB 13768)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei88Transition state stabilizerUniRule annotation1
Active sitei92Proton acceptorUniRule annotation1
Metal bindingi260Iron (heme axial ligand)UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Protein family/group databases

PeroxiBasei2697. CsalCP01_DSM3043.

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidaseUniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CPUniRule annotation
Alternative name(s):
Peroxidase/catalaseUniRule annotation
Gene namesi
Name:katGUniRule annotation
Ordered Locus Names:Csal_0159
OrganismiChromohalobacter salexigens (strain DSM 3043 / ATCC BAA-138 / NCIMB 13768)
Taxonomic identifieri290398 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaOceanospirillalesHalomonadaceaeChromohalobacter
Proteomesi
  • UP000000239 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003547611 – 717Catalase-peroxidaseAdd BLAST717

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki91 ↔ 219Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-245)UniRule annotation
Cross-linki219 ↔ 245Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-91)UniRule annotation

Post-translational modificationi

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Proteomic databases

PRIDEiQ1R185.

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi290398.Csal_0159.

Structurei

3D structure databases

ProteinModelPortaliQ1R185.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiQPEEMML.
OrthoDBiPOG091H05R1.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1R185-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGKCPVMHG GNTSTGTSNK DWWPEGINLD ILHQHDRKTN PMDPDFNYRE
60 70 80 90 100
EVKKLDVQAL KNDLRQLMVD SQAWWPADWG SYVGMFARVA WHSAGSYRLA
110 120 130 140 150
DGRGGGGTGN QRFAPLNSWP DNVNTDKGRR LLWPIKKKYG NKISWADLMV
160 170 180 190 200
LSGTIAYEVA GLKTYGFAFG REDIWHPEKD IYWGDEKEWL APSDERYADV
210 220 230 240 250
EKPDTMENPL AAVQMGLIYV NPEGVNGQPD PQKTAEQVRE TFARMAMNDE
260 270 280 290 300
ETAALTAGGH TIGKCHGNGE AENLSAEPEA ADVEYQGIGW MNTKGRGIGR
310 320 330 340 350
DTVVSGIEGA WTKNPTQWDM GWFDMLFNHE WELKKSPAGA WQWEPVDIAE
360 370 380 390 400
EDMPVDVEDP SIRRMPIMTD ADMAMKVDPV YNEICRKFMD DPEYFSETFA
410 420 430 440 450
KAWFKLTHRD LGPKARYIGP DVPADDLIWQ DPIPAGSIAY CEEVVKQKIA
460 470 480 490 500
ESGLSIGEMV STAWDSARTY RGSDMRGGAN GARIRLAPQK TWPGNEPERL
510 520 530 540 550
AKVLDVYERI SAETGASIAD VIVLGGSVGI ERAAKAAGHD VHVPFLKGRG
560 570 580 590 600
DATDEMTDAA SFAPLEPLAD GFRNWQKQDY VVKPEEMLLD RAQLMGLTGP
610 620 630 640 650
EMTVLIGGMR VLGTNHGGTR HGVFTDREGQ LTNDFFVNLT DMGNTWKPAG
660 670 680 690 700
NNVYEIRDRE TDAVKWTASR VDLVFGSNSL LRSYAEVYAQ DDNEEKFVND
710
FVAAWTKVMN ADRFDVA
Length:717
Mass (Da):80,005
Last modified:May 16, 2006 - v1
Checksum:i38EB720EB9D80F35
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000285 Genomic DNA. Translation: ABE57523.1.
RefSeqiWP_011505469.1. NC_007963.1.

Genome annotation databases

EnsemblBacteriaiABE57523; ABE57523; Csal_0159.
KEGGicsa:Csal_0159.
PATRICi21444008. VBIChrSal113723_0163.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000285 Genomic DNA. Translation: ABE57523.1.
RefSeqiWP_011505469.1. NC_007963.1.

3D structure databases

ProteinModelPortaliQ1R185.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi290398.Csal_0159.

Protein family/group databases

PeroxiBasei2697. CsalCP01_DSM3043.

Proteomic databases

PRIDEiQ1R185.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABE57523; ABE57523; Csal_0159.
KEGGicsa:Csal_0159.
PATRICi21444008. VBIChrSal113723_0163.

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiQPEEMML.
OrthoDBiPOG091H05R1.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKATG_CHRSD
AccessioniPrimary (citable) accession number: Q1R185
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: May 16, 2006
Last modified: October 5, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.