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Q1R153

- GCH4_CHRSD

UniProt

Q1R153 - GCH4_CHRSD

Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Chromohalobacter salexigens (strain DSM 3043 / ATCC BAA-138 / NCIMB 13768)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (16 May 2006)
      Previous versions | rss
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    • Comment

    Functioni

    Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

    Catalytic activityi

    GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei153 – 1531May be catalytically importantUniRule annotation

    GO - Molecular functioni

    1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    UniPathwayiUPA00848; UER00151.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
    Gene namesi
    Name:folE2UniRule annotation
    Ordered Locus Names:Csal_0191
    OrganismiChromohalobacter salexigens (strain DSM 3043 / ATCC BAA-138 / NCIMB 13768)
    Taxonomic identifieri290398 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaOceanospirillalesHalomonadaceaeChromohalobacter
    ProteomesiUP000000239: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 304304GTP cyclohydrolase FolE2PRO_0000289485Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi290398.Csal_0191.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1R153.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GTP cyclohydrolase IV family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1469.
    HOGENOMiHOG000247517.
    KOiK09007.
    OMAiAGRTTIQ.
    OrthoDBiEOG6X6RBH.

    Family and domain databases

    HAMAPiMF_01527_B. GTP_cyclohydrol_B.
    InterProiIPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view]
    PfamiPF02649. GCHY-1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q1R153-1 [UniParc]FASTAAdd to Basket

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    MQEPKNSQTL HDVANGASDL EGPLAWVGME DIALPFRLAN SAVNGRASAG    50
    VSLDATSARG IHMSRLYLAL EALEHEEVTL SGLGAVLQRF LASHDGLART 100
    AFLDLSGDVL IKRPALISPR AGWKAYPCAL RCRQDTQGMQ AVLEVTIGYS 150
    STCPCSAALA RQSIQQAFDE DFTDMPISHE AVRTWLGSEQ GILATPHSQR 200
    SQAHLSLRLA DDLETLPVTA LIDTVEDALG TALQTAVKRV DEQAFALANG 250
    QNLMFCEDAA RRVRHALQAR DEVQGFRVRI VHAESLHAHD AVAHAEWNWT 300
    PNSP 304
    Length:304
    Mass (Da):32,972
    Last modified:May 16, 2006 - v1
    Checksum:i39011AF05A0127BC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000285 Genomic DNA. Translation: ABE57555.1.
    RefSeqiWP_011505501.1. NC_007963.1.
    YP_572254.1. NC_007963.1.

    Genome annotation databases

    EnsemblBacteriaiABE57555; ABE57555; Csal_0191.
    GeneIDi4026757.
    KEGGicsa:Csal_0191.
    PATRICi21444074. VBIChrSal113723_0196.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000285 Genomic DNA. Translation: ABE57555.1 .
    RefSeqi WP_011505501.1. NC_007963.1.
    YP_572254.1. NC_007963.1.

    3D structure databases

    ProteinModelPortali Q1R153.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 290398.Csal_0191.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABE57555 ; ABE57555 ; Csal_0191 .
    GeneIDi 4026757.
    KEGGi csa:Csal_0191.
    PATRICi 21444074. VBIChrSal113723_0196.

    Phylogenomic databases

    eggNOGi COG1469.
    HOGENOMi HOG000247517.
    KOi K09007.
    OMAi AGRTTIQ.
    OrthoDBi EOG6X6RBH.

    Enzyme and pathway databases

    UniPathwayi UPA00848 ; UER00151 .

    Family and domain databases

    HAMAPi MF_01527_B. GTP_cyclohydrol_B.
    InterProi IPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view ]
    Pfami PF02649. GCHY-1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 3043 / ATCC BAA-138 / NCIMB 13768.

    Entry informationi

    Entry nameiGCH4_CHRSD
    AccessioniPrimary (citable) accession number: Q1R153
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: May 16, 2006
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3