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Q1R153 (GCH4_CHRSD) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GTP cyclohydrolase FolE2

EC=3.5.4.16
Gene names
Name:folE2
Ordered Locus Names:Csal_0191
OrganismChromohalobacter salexigens (strain DSM 3043 / ATCC BAA-138 / NCIMB 13768) [Complete proteome] [HAMAP]
Taxonomic identifier290398 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaOceanospirillalesHalomonadaceaeChromohalobacter

Protein attributes

Sequence length304 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts GTP to 7,8-dihydroneopterin triphosphate By similarity. HAMAP-Rule MF_01527

Catalytic activity

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP-Rule MF_01527

Pathway

Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP-Rule MF_01527

Sequence similarities

Belongs to the GTP cyclohydrolase IV family.

Ontologies

Keywords
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_process7,8-dihydroneopterin 3'-triphosphate biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionGTP cyclohydrolase I activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 304304GTP cyclohydrolase FolE2 HAMAP-Rule MF_01527
PRO_0000289485

Sites

Site1531May be catalytically important By similarity

Sequences

Sequence LengthMass (Da)Tools
Q1R153 [UniParc].

Last modified May 16, 2006. Version 1.
Checksum: 39011AF05A0127BC

FASTA30432,972
        10         20         30         40         50         60 
MQEPKNSQTL HDVANGASDL EGPLAWVGME DIALPFRLAN SAVNGRASAG VSLDATSARG 

        70         80         90        100        110        120 
IHMSRLYLAL EALEHEEVTL SGLGAVLQRF LASHDGLART AFLDLSGDVL IKRPALISPR 

       130        140        150        160        170        180 
AGWKAYPCAL RCRQDTQGMQ AVLEVTIGYS STCPCSAALA RQSIQQAFDE DFTDMPISHE 

       190        200        210        220        230        240 
AVRTWLGSEQ GILATPHSQR SQAHLSLRLA DDLETLPVTA LIDTVEDALG TALQTAVKRV 

       250        260        270        280        290        300 
DEQAFALANG QNLMFCEDAA RRVRHALQAR DEVQGFRVRI VHAESLHAHD AVAHAEWNWT 


PNSP 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000285 Genomic DNA. Translation: ABE57555.1.
RefSeqYP_572254.1. NC_007963.1.

3D structure databases

ProteinModelPortalQ1R153.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING290398.Csal_0191.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABE57555; ABE57555; Csal_0191.
GeneID4026757.
KEGGcsa:Csal_0191.
PATRIC21444074. VBIChrSal113723_0196.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1469.
HOGENOMHOG000247517.
KOK09007.
OMAAGRTTIQ.
OrthoDBEOG6X6RBH.

Enzyme and pathway databases

UniPathwayUPA00848; UER00151.

Family and domain databases

HAMAPMF_01527_B. GTP_cyclohydrol_B.
InterProIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamPF02649. GCHY-1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGCH4_CHRSD
AccessionPrimary (citable) accession number: Q1R153
Entry history
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 16, 2006
Last modified: May 14, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways