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Q1R153

- GCH4_CHRSD

UniProt

Q1R153 - GCH4_CHRSD

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Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Chromohalobacter salexigens (strain DSM 3043 / ATCC BAA-138 / NCIMB 13768)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei153 – 1531May be catalytically importantUniRule annotation

GO - Molecular functioni

  1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
Gene namesi
Name:folE2UniRule annotation
Ordered Locus Names:Csal_0191
OrganismiChromohalobacter salexigens (strain DSM 3043 / ATCC BAA-138 / NCIMB 13768)
Taxonomic identifieri290398 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaOceanospirillalesHalomonadaceaeChromohalobacter
ProteomesiUP000000239: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 304304GTP cyclohydrolase FolE2PRO_0000289485Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi290398.Csal_0191.

Structurei

3D structure databases

ProteinModelPortaliQ1R153.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1469.
HOGENOMiHOG000247517.
KOiK09007.
OMAiAGRTTIQ.
OrthoDBiEOG6X6RBH.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1R153 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQEPKNSQTL HDVANGASDL EGPLAWVGME DIALPFRLAN SAVNGRASAG
60 70 80 90 100
VSLDATSARG IHMSRLYLAL EALEHEEVTL SGLGAVLQRF LASHDGLART
110 120 130 140 150
AFLDLSGDVL IKRPALISPR AGWKAYPCAL RCRQDTQGMQ AVLEVTIGYS
160 170 180 190 200
STCPCSAALA RQSIQQAFDE DFTDMPISHE AVRTWLGSEQ GILATPHSQR
210 220 230 240 250
SQAHLSLRLA DDLETLPVTA LIDTVEDALG TALQTAVKRV DEQAFALANG
260 270 280 290 300
QNLMFCEDAA RRVRHALQAR DEVQGFRVRI VHAESLHAHD AVAHAEWNWT

PNSP
Length:304
Mass (Da):32,972
Last modified:May 16, 2006 - v1
Checksum:i39011AF05A0127BC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000285 Genomic DNA. Translation: ABE57555.1.
RefSeqiWP_011505501.1. NC_007963.1.
YP_572254.1. NC_007963.1.

Genome annotation databases

EnsemblBacteriaiABE57555; ABE57555; Csal_0191.
GeneIDi4026757.
KEGGicsa:Csal_0191.
PATRICi21444074. VBIChrSal113723_0196.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000285 Genomic DNA. Translation: ABE57555.1 .
RefSeqi WP_011505501.1. NC_007963.1.
YP_572254.1. NC_007963.1.

3D structure databases

ProteinModelPortali Q1R153.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 290398.Csal_0191.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABE57555 ; ABE57555 ; Csal_0191 .
GeneIDi 4026757.
KEGGi csa:Csal_0191.
PATRICi 21444074. VBIChrSal113723_0196.

Phylogenomic databases

eggNOGi COG1469.
HOGENOMi HOG000247517.
KOi K09007.
OMAi AGRTTIQ.
OrthoDBi EOG6X6RBH.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .

Family and domain databases

HAMAPi MF_01527_B. GTP_cyclohydrol_B.
InterProi IPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view ]
Pfami PF02649. GCHY-1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 3043 / ATCC BAA-138 / NCIMB 13768.

Entry informationi

Entry nameiGCH4_CHRSD
AccessioniPrimary (citable) accession number: Q1R153
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 16, 2006
Last modified: October 1, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3