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Reviewed, UniProtKB/Swiss-Prot Q1R0J2 (LLDD_CHRSD)

Last modified June 16, 2009. Version 27. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    L-lactate dehydrogenase [cytochrome]
    EC=1.1.2.3
Gene names
Name: lldD
Ordered Locus Names: Csal_0404
OrganismChromohalobacter salexigens (strain DSM 3043 / ATCC BAA-138 / NCIMB 13768) [Complete proteome] [HAMAP]
Taxonomic identifier290398 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Oceanospirillales › Halomonadaceae › Chromohalobacter

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Protein attributes

Sequence length392 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Catalytic activity

(S)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c + 2 H+. HAMAP MF_01559

Cofactor

FMN By similarity.

Sequence similarities

Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.

Contains 1 FMN hydroxy acid dehydrogenase domain.

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Ontologies

Keywords
   LigandFMN
Flavoprotein
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processoxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionFMN binding

Inferred from electronic annotation. Source: InterPro

L-lactate dehydrogenase (cytochrome) activity

Inferred from electronic annotation. Source: HAMAP

electron carrier activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 392392L-lactate dehydrogenase [cytochrome] HAMAP MF_01559
PRO_1000068977

Regions

Domain1 – 380380FMN hydroxy acid dehydrogenase
Nucleotide binding306 – 33025FMN By similarity

Sites

Active site2751Proton acceptor By similarity
Binding site241Substrate Potential
Binding site1061FMN By similarity
Binding site1271FMN By similarity
Binding site1291Substrate By similarity
Binding site1551FMN By similarity
Binding site1641Substrate By similarity
Binding site2511FMN By similarity
Binding site2781Substrate Potential

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Sequences

Sequence LengthMass (Da)Tools
Q1R0J2-1 [UniParc].

Last modified May 16, 2006. Version 1.
Checksum: 631A171A271F1091

FASTA39242,414
        10         20         30         40         50         60 
MIISASTDYR HAAKRRLPPF LFHYADGGAY AEHTLRRNVE DLAGIALRQR VLKDMSHLSL 

        70         80         90        100        110        120 
ETELFGEPLA MPVALAPVGL AGMYARRGEV QAARAAASKG IPFTLSTVSV CPIAEVASAI 

       130        140        150        160        170        180 
ERPLWFQLYV LRDRGFMKHV LERAKAAGVK TLVFTVDMPV PGARYRDAHS GMSGKHGGLR 

       190        200        210        220        230        240 
RMLQAVTHPS WAWDVGLHGR PHDLGNVSDY RGQPTELEDY IAWLGNNFDP SISWKDLEWI 

       250        260        270        280        290        300 
REFWDGPMII KGILDPEDAR DAVRFGADGI VVSNHGGRQL DGVPSTARAL PAIADAVKGD 

       310        320        330        340        350        360 
LAILADSGVR NGLDVVRMIA MGADTILLGR AYIYALATAG EAGVAHLLEL FEKEMRVAMT 

       370        380        390 
LTGARSIAEL GSDSLVTGSA AASIERTLSP SL

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References

[1]"Complete sequence of Chromohalobacter salexigens DSM 3043."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Saunders E., Schmutz J. expand/collapse author list , Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Csonka L.N., O'Conner K., Vreeland R.H., Oren A., Vargas C., Nieto J., Arahal D.R., Goodner B., Wheeler C., Hall P., Ewing A., Benson L., McBeath D., Canovas D., Richardson P.
Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

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Cross-references

Sequence databases

CP000285 Genomic DNA. Translation: ABE57766.1.
RefSeqYP_572465.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID4025998.
GenomeReviewsGene locus Csal_0404 in contig CP000285_GR.
KEGGcsa:Csal_0404.
NMPDRfig|290398.4.peg.512.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ1R0J2.
OMAQ1R0J2. NFDPSIG.

Enzyme and pathway databases

BioCycCSAL290398:CSAL_0404-MON.

Family and domain databases

HAMAPMF_01559.
[Tree]
InterProIPR012133. a-Hydoxy_acid_DH_FMN.
IPR013785. Aldolase_TIM.
IPR000262. FMN-dep_DH.
IPR017934. FMN-dep_OHA_DH.
IPR008259. FMN_hydac_DH_AS.
[Graphical view]
Gene3DG3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
PfamPF01070. FMN_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000138. Al-hdrx_acd_dh. 1 hit.
PROSITEPS00557. FMN_HYDROXY_ACID_DH_1. 1 hit.
PS51349. FMN_HYDROXY_ACID_DH_2. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameLLDD_CHRSD
AccessionPrimary (citable) accession number: Q1R0J2
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 16, 2006
Last modified: June 16, 2009
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents