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Q1R0B2 (ISPH_CHRSD) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
4-hydroxy-3-methylbut-2-enyl diphosphate reductase
EC=1.17.1.2
Gene names
Name:ispH
Ordered Locus Names:Csal_0484
OrganismChromohalobacter salexigens (strain DSM 3043 / ATCC BAA-138 / NCIMB 13768) [Complete proteome] [HAMAP]
Taxonomic identifier290398 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Oceanospirillales › Halomonadaceae › Chromohalobacter

Protein attributes

Sequence length317 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) By similarity. HAMAP MF_00191

Catalytic activity

Isopentenyl diphosphate + NAD(P)+ + H2O = (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H. HAMAP MF_00191

Dimethylallyl diphosphate + NAD(P)+ + H2O = (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H. HAMAP MF_00191

Cofactor

Binds 1 3Fe-4S cluster By similarity. HAMAP MF_00191

Pathway

Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from (2E)-4-hydroxy-3-methylbutenyl diphosphate: step 1/1. HAMAP MF_00191

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 6/6. HAMAP MF_00191

Sequence similarities

Belongs to the IspH family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3173174-hydroxy-3-methylbut-2-enyl diphosphate reductase HAMAP MF_00191
PRO_1000021103

Sequences

Sequence LengthMass (Da)Tools
Q1R0B2 [UniParc].

Last modified May 16, 2006. Version 1.
Checksum: 45BF582982AFD3C9

FASTA31734,913
        10         20         30         40         50         60 
MQIKLANPRG FCAGVDRAIE IVNRALDVFG PPIYVRHEVV HNRFVVDSLR ERGAVFVEEL 

        70         80         90        100        110        120 
HEVPDDVIVI FSAHGVSRAV QQEAERRGLR IFDATCPLVT KVHMEVLRYA KRGQECVLIG 

       130        140        150        160        170        180 
HAGHPEVEGT MGRYDTSFGG QIYLVEDEAD VENLEVNGPE RLAFVTQTTL SMDDTSRVID 

       190        200        210        220        230        240 
ALRAKFPQID GPRKDDICYA TQNRQDAVRG LASESDLVLV VGSPNSSNSN RLRELAERTG 

       250        260        270        280        290        300 
TPAYLIDTAE QIRPEWLTDV SAIGITAGAS APEVLVQAVI ERLQSLGAEA PDELAGQAEN 

       310 
ITFSMPQELR ERVIASE

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000285 Genomic DNA. Translation: ABE57846.1.
RefSeqYP_572545.1. NC_007963.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGQ1R0B2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4026508.
GenomeReviewsGene locus Csal_0484 in contig CP000285_GR.
KEGGcsa:Csal_0484.
NMPDRfig|290398.4.peg.43.
PATRIC21444700. VBIChrSal113723_0499.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0761.
HOGENOMHBG335228.
OMAVQEMQLL.

Enzyme and pathway databases

BioCycCSAL290398:CSAL_0484-MONOMER.

Family and domain databases

HAMAPMF_00191. IspH.
[Tree]
InterProIPR003451. LytB.
[Graphical view]
KOK03527.
PfamPF02401. LYTB. 1 hit.
[Graphical view]
TIGRFAMsTIGR00216. IspH_lytB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameISPH_CHRSD
AccessionPrimary (citable) accession number: Q1R0B2
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 16, 2006
Last modified: January 25, 2012
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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