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Q1R020

- LPXB_CHRSD

UniProt

Q1R020 - LPXB_CHRSD

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Protein

Lipid-A-disaccharide synthase

Gene
lpxB, Csal_0576
Organism
Chromohalobacter salexigens (strain DSM 3043 / ATCC BAA-138 / NCIMB 13768)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthase (EC:2.4.1.182)
Gene namesi
Name:lpxB
Ordered Locus Names:Csal_0576
OrganismiChromohalobacter salexigens (strain DSM 3043 / ATCC BAA-138 / NCIMB 13768)
Taxonomic identifieri290398 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaOceanospirillalesHalomonadaceaeChromohalobacter
ProteomesiUP000000239: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 386386Lipid-A-disaccharide synthaseUniRule annotationPRO_0000255174Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi290398.Csal_0576.

Structurei

3D structure databases

ProteinModelPortaliQ1R020.

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018003.
KOiK00748.
OMAiVSPITYR.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1R020-1 [UniParc]FASTAAdd to Basket

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MRIYLVAGEL SGDILGAGLM QALKRRHPDA EFRGIGGPRM LAEGMQSLYP    50
LETLSVMGLV EVLKHLPGLI KVRRHLRRDA LAWQPDVMIG IDAPDFNLGL 100
ERQLRATGMR TVHYVSPSVW AWRQGRVKTI ARSVDAMLTF LPFEAAFYAR 150
HQVPVAFVGH PLADELPLVN DRQAARTALG LSSTAPLLAV LPGSRGNEIR 200
FLGPTFLDSA VWLRERVPGL QVVIPAASPA RRQELEVLLA THPAREFVHL 250
RDGESRQAMT AADAVLLASG TAALEAMLCH RPMVVAYKMA AATHWLAKRM 300
VKTEWISLPN LIAQETLVPE LVQEDASCEA IGEALLTWLG DETHRQATET 350
RFAALHATLQ RGASERAAEA IDSLVVHGRL PEEPTA 386
Length:386
Mass (Da):42,361
Last modified:May 16, 2006 - v1
Checksum:iDE844FE223171A53
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000285 Genomic DNA. Translation: ABE57938.1.
RefSeqiWP_011505884.1. NC_007963.1.
YP_572637.1. NC_007963.1.

Genome annotation databases

EnsemblBacteriaiABE57938; ABE57938; Csal_0576.
GeneIDi4026313.
KEGGicsa:Csal_0576.
PATRICi21444902. VBIChrSal113723_0591.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000285 Genomic DNA. Translation: ABE57938.1 .
RefSeqi WP_011505884.1. NC_007963.1.
YP_572637.1. NC_007963.1.

3D structure databases

ProteinModelPortali Q1R020.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 290398.Csal_0576.

Protein family/group databases

CAZyi GT19. Glycosyltransferase Family 19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABE57938 ; ABE57938 ; Csal_0576 .
GeneIDi 4026313.
KEGGi csa:Csal_0576.
PATRICi 21444902. VBIChrSal113723_0591.

Phylogenomic databases

eggNOGi COG0763.
HOGENOMi HOG000018003.
KOi K00748.
OMAi VSPITYR.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 3043 / ATCC BAA-138 / NCIMB 13768.

Entry informationi

Entry nameiLPXB_CHRSD
AccessioniPrimary (citable) accession number: Q1R020
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: May 16, 2006
Last modified: September 3, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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