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Q1QZX9 (PYRG_CHRSD) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
CTP synthase
EC=6.3.4.2
Alternative name(s):
CTP synthetase
UTP--ammonia ligase
Gene names
Name:pyrG
Ordered Locus Names:Csal_0617
OrganismChromohalobacter salexigens (strain DSM 3043 / ATCC BAA-138 / NCIMB 13768) [Complete proteome] [HAMAP]
Taxonomic identifier290398 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Oceanospirillales › Halomonadaceae › Chromohalobacter

Protein attributes

Sequence length548 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen By similarity. HAMAP MF_01227

Catalytic activity

ATP + UTP + NH3 = ADP + phosphate + CTP. HAMAP MF_01227

Enzyme regulation

Allosterically activated by GTP, when glutamine is the substrate. Inhibited by CTP By similarity. HAMAP MF_01227

Pathway

Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2. HAMAP MF_01227

Subunit structure

Homotetramer By similarity. HAMAP MF_01227

Sequence similarities

Belongs to the CTP synthase family.

Contains 1 glutamine amidotransferase type-1 domain.

Ontologies

Keywords
   Biological processPyrimidine biosynthesis
   DomainGlutamine amidotransferase
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processglutamine metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

pyrimidine nucleotide biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

CTP synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 548548CTP synthase HAMAP MF_01227
PRO_0000266095

Regions

Domain290 – 541252Glutamine amidotransferase type-1
Region1 – 252252Aminator domain HAMAP MF_01227

Sites

Active site3781Nucleophile By similarity
Active site5141 By similarity
Active site5161 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q1QZX9 [UniParc].

Last modified May 16, 2006. Version 1.
Checksum: F765AC07F2405337

FASTA54860,663
        10         20         30         40         50         60 
MTRYIFVTGG VVSSLGKGIA SASLAAILEA RGLKVTILKL DPYINVDPGT MSPFQHGEVF 

        70         80         90        100        110        120 
VTEDGAETDL DLGHYERFIR TKMTQGNNFT TGRVYEHVLR KERRGDYLGG TVQVIPHITD 

       130        140        150        160        170        180 
EIKRRVYEGG DGFDVALVEI GGTVGDIESL PFLEATRQIR SEKGANQAIF MHLTLVPYIK 

       190        200        210        220        230        240 
TAGETKTKPT QHSVKELRSI GIQPDILICR SEVELEESER RKIALFTNVE ERAVVPLQDA 

       250        260        270        280        290        300 
DTIYRIPLML HEHGLDDIIC DKLRIEADEV DLAEWVRVLD AKLNPLKSVN IAMVGKYMEL 

       310        320        330        340        350        360 
LDAYKSLNEA LIHAGIQGRV KVNIDYIDSE DIEHHGTERL AGKDAILVPG GFGERGVEGK 

       370        380        390        400        410        420 
IATARYAREN GVPYLGICLG MQVAVIEYAR HVAGWADANS TEFTHDTQHP VVGLITEWVN 

       430        440        450        460        470        480 
AEGKIELRDA ASDLGGTMRL GGQVCHLKPG TRAHEAYGLD EITERHRHRF EVNNQFVEAL 

       490        500        510        520        530        540 
ESAGLVISGK SADHSLVEMI ELPEHPWYVA CQFHPEFTST PRDGHPLFSG FVNAALAYKA 


ARARAQQS

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000285 Genomic DNA. Translation: ABE57979.1.
RefSeqYP_572678.1. NC_007963.1.

3D structure databases

ProteinModelPortalQ1QZX9.
SMRQ1QZX9. Positions 2-543.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ1QZX9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4029086.
GenomeReviewsGene locus Csal_0617 in contig CP000285_GR.
KEGGcsa:Csal_0617.
NMPDRfig|290398.4.peg.420.
PATRIC21444992. VBIChrSal113723_0636.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0504.
HOGENOMHBG597806.
OMARVTMQKL.
ProtClustDBPRK05380.

Enzyme and pathway databases

BioCycCSAL290398:CSAL_0617-MONOMER.

Family and domain databases

HAMAPMF_01227. PyrG.
[Tree]
InterProIPR004468. CTP_synthase.
IPR017456. CTP_synthase_N.
IPR017926. GATASE_1.
[Graphical view]
KOK01937.
PANTHERPTHR11550. PyrG_synth. 1 hit.
PfamPF06418. CTP_synth_N. 1 hit.
PF00117. GATase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00337. PyrG. 1 hit.
PROSITEPS51273. GATASE_TYPE_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePYRG_CHRSD
AccessionPrimary (citable) accession number: Q1QZX9
Entry history
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: May 16, 2006
Last modified: January 25, 2012
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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