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Q1QZS5 (METE_CHRSD) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase
EC=2.1.1.14
Alternative name(s):
Cobalamin-independent methionine synthase
Methionine synthase, vitamin-B12 independent isozyme
Gene names
Name:metE
Ordered Locus Names:Csal_0672
OrganismChromohalobacter salexigens (strain DSM 3043 / ATCC BAA-138 / NCIMB 13768) [Complete proteome] [HAMAP]
Taxonomic identifier290398 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Oceanospirillales › Halomonadaceae › Chromohalobacter

Protein attributes

Sequence length761 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation By similarity. HAMAP MF_00172

Catalytic activity

5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine. HAMAP MF_00172

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP MF_00172

Pathway

Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetE route): step 1/1. HAMAP MF_00172

Sequence similarities

Belongs to the vitamin-B12 independent methionine synthase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 7617615-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase HAMAP MF_00172
PRO_1000017237

Sites

Metal binding6471Zinc By similarity
Metal binding6491Zinc By similarity
Metal binding7321Zinc By similarity

Sequences

Sequence LengthMass (Da)Tools
Q1QZS5 [UniParc].

Last modified May 16, 2006. Version 1.
Checksum: 58D0522695639728

FASTA76184,663
        10         20         30         40         50         60 
MALAHILGYP RIGANRELKK AVEAYWKGDI DQAELERRGQ ALRAEHWQAS RDAGLDFVTV 

        70         80         90        100        110        120 
GDFAFYDQVL NVSAMLGAVP PRFGAIDGDV DLDTTFRMAR GRAPSGTPAA ACEMTKYFDT 

       130        140        150        160        170        180 
NYHYLVPELH AGQRFRVAST RLFDEVAEAQ AAGHPVKVAL LGPVSWLWLG KEKSAGLDRL 

       190        200        210        220        230        240 
TLLDDVLSVY GEILERLAAQ GVEWVQLDEP ALVQDLPRDW RQAFESAYNK LQSAPVKLLL 

       250        260        270        280        290        300 
ATYFGALGDN LGLAAGLPVA GLHIDTVRAP EQLDAVLDRL PTYKVLSLGA IDGRNIWRAD 

       310        320        330        340        350        360 
LAALRERLQV ARARLGERLW ISASCSLLHV PVDLDAETDL DAELKSWLAF ARQKLDEIVT 

       370        380        390        400        410        420 
LAHLLDGRAT PEDTARLEAA TSALDARRQS PRIHKPAVGE RLAAVSADDA ERASPYATRA 

       430        440        450        460        470        480 
KAQHRHLDLP LFPTTTIGSF PQTQDIRAAR RAFKSGELSR DDYEARMRDE IAHAVERQEA 

       490        500        510        520        530        540 
LAIDVPVHGE PERNDMVEYF GELLDGFAFT RFGWVQSYGS RCVKPPVIFG DVSRPGPMTV 

       550        560        570        580        590        600 
RWSEYAQSLT DKPMKGMLTG PVTILQWSFV RDDQPRDATC RQIALSLRDE VADLEAAGIK 

       610        620        630        640        650        660 
IIQIDEPALR EGLPLRQGEW QEYLDWAVKS FKLSAAVARD ETQIHTHMCY SEFNDIIAAI 

       670        680        690        700        710        720 
AALDADVITI ETSRSDMELL DAFQDFAYPN EIGPGVYDIH SPNIPEVEWM VSLMEKAAEK 

       730        740        750        760 
IPAERLWVNP DCGLKTRGWA EVEPALANMV EAARELRRRY G

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000285 Genomic DNA. Translation: ABE58033.1.
RefSeqYP_572732.1. NC_007963.1.

3D structure databases

ProteinModelPortalQ1QZS5.
SMRQ1QZS5. Positions 4-759.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ1QZS5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4026700.
GenomeReviewsGene locus Csal_0672 in contig CP000285_GR.
KEGGcsa:Csal_0672.
NMPDRfig|290398.4.peg.569.
PATRIC21445120. VBIChrSal113723_0697.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0620.
HOGENOMHBG287495.
OMARNIWRAN.
ProtClustDBPRK05222.

Enzyme and pathway databases

BioCycCSAL290398:CSAL_0672-MONOMER.

Family and domain databases

HAMAPMF_00172. Meth_synth.
[Tree]
InterProIPR013215. Cbl-indep_Met_Synth_N.
IPR006276. Cobalamin-indep_Met_synthase.
IPR002629. Methionine_synth.
[Graphical view]
KOK00549.
PfamPF08267. Meth_synt_1. 1 hit.
PF01717. Meth_synt_2. 1 hit.
[Graphical view]
PIRSFPIRSF000382. MeTrfase_B12_ind. 1 hit.
TIGRFAMsTIGR01371. Met_syn_B12ind. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMETE_CHRSD
AccessionPrimary (citable) accession number: Q1QZS5
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 16, 2006
Last modified: January 25, 2012
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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