Q1QZ29 (APAH_CHRSD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Bis(5'-nucleosyl)-tetraphosphatase, symmetrical
EC=3.6.1.41

Alternative name(s):
Ap4A hydrolase
Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase
Diadenosine tetraphosphatase

Gene names

Name:	apaH
Ordered Locus Names:	Csal_0922

Organism

Chromohalobacter salexigens (strain DSM 3043 / ATCC BAA-138 / NCIMB 13768) [Complete proteome] [HAMAP]

Taxonomic identifier

290398 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Oceanospirillales › Halomonadaceae › Chromohalobacter

Protein attributes

Sequence length	272 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP By similarity. HAMAP MF_00199
Catalytic activity	P1,P(4)-bis(5'-adenosyl) tetraphosphate + H2O = 2 ADP. HAMAP MF_00199
Sequence similarities	Belongs to the Ap4A hydrolase family.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 272	272	Bis(5'-nucleosyl)-tetraphosphatase, symmetrical HAMAP MF_00199		PRO_1000012053

Sequences

	Sequence		Length	Mass (Da)
	Q1QZ29 [UniParc]. Last modified May 16, 2006. Version 1. Checksum: F7989695BBE54BAD	FASTA	272	29,679
	10 20 30 40 50 60 MSTYAIGDLQ GCHAEFEALL ERIAFEPRRD RLWLVGDLVN RGPGSLACLR AVKALGDSAR 70 80 90 100 110 120 VVLGNHDLHL LAAAWAGAPL KRSDTLAPIL EADDRDELLD WLRRQPLLVR DDELDAVMTH 130 140 150 160 170 180 AGLPPHWSVT QAAEHAAEVE RALRGEAVGD FLAAMYGNSP ARWTDELEGI DRLRVIVNTF 190 200 210 220 230 240 TRMRFIAADG TLDFAAKEGL DSAPEGFAPW FTYARDDDPR IVFGHWAALQ GATPGARVRA 250 260 270 LALDTGCVWG GALTALDLVS GEYHVEPAHA SR

References

[1]

"Complete sequence of Chromohalobacter salexigens DSM 3043." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Saunders E., Schmutz J. , Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Csonka L.N., O'Conner K., Vreeland R.H., Oren A., Vargas C., Nieto J., Arahal D.R., Goodner B., Wheeler C., Hall P., Ewing A., Benson L., McBeath D., Canovas D., Richardson P. Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 3043 / ATCC BAA-138 / NCIMB 13768.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000285 Genomic DNA. Translation: ABE58279.1.
RefSeq	YP_572978.1. NC_007963.1.
3D structure databases
ProteinModelPortal	Q1QZ29.
SMR	Q1QZ29. Positions 2-268.
ModBase	Search...
Protein-protein interaction databases
STRING	Q1QZ29.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4027429.
GenomeReviews	Gene locus Csal_0922 in contig CP000285_GR.
KEGG	csa:Csal_0922.
NMPDR	fig|290398.4.peg.914.
PATRIC	21445628. VBIChrSal113723_0940.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0639.
HOGENOM	HBG724457.
OMA	LVFGHWA.
ProtClustDB	PRK00166.
Enzyme and pathway databases
BioCyc	CSAL290398:CSAL_0922-MONOMER.
Family and domain databases
HAMAP	MF_00199. ApaH. [Tree]
InterPro	IPR004617. ApaH. IPR004843. Metallo_PEstase_dom. [Graphical view]
KO	K01525.
Pfam	PF00149. Metallophos. 1 hit. [Graphical view]
PIRSF	PIRSF000903. B5n-ttraPtase_sm. 1 hit.
TIGRFAMs	TIGR00668. ApaH. 1 hit.
ProtoNet	Search...

Entry information

Entry name

APAH_CHRSD

Accession

Primary (citable) accession number: Q1QZ29

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	May 16, 2006
Last modified:	January 25, 2012
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program