Reviewed, UniProtKB/Swiss-Prot Q1QYD9 (BIOD_CHRSD)

Names and origin

Protein names

Recommended name:
    Dethiobiotin synthetase
    EC=6.3.3.3
Alternative name(s):
    Dethiobiotin synthase
    DTB synthetase
      Short name=DTBS

Gene names

Name:	bioD
Ordered Locus Names:	Csal_1163

Organism

Chromohalobacter salexigens (strain DSM 3043 / ATCC BAA-138 / NCIMB 13768) [Complete proteome] [HAMAP]

Taxonomic identifier

290398 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Oceanospirillales › Halomonadaceae › Chromohalobacter

Protein attributes

Sequence length	237 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + 7,8-diaminononanoate + CO2 = ADP + phosphate + dethiobiotin. HAMAP MF_00336
Cofactor	Magnesium By similarity.
Pathway	Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 1/2. HAMAP MF_00336
Sequence similarities	Belongs to the dethiobiotin synthetase family.

Ontologies

Keywords
Biological process	Biotin biosynthesis
Ligand	ATP-binding Magnesium Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	biotin biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP dethiobiotin synthase activity Inferred from electronic annotation. Source: HAMAP magnesium ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 237	237	Dethiobiotin synthetase HAMAP MF_00336		PRO_0000302497
Regions
	Nucleotide binding	8 – 16	9	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q1QYD9-1 [UniParc]. Last modified May 16, 2006. Version 1. Checksum: 798C42FAF3A66E1F	FASTA	237	24,790
	10 20 30 40 50 60 MTTYFVTGTD TDAGKTLVAS GLLALARRRG LTTLGLKPVA SGCESTTEGL RNIDALTLQA 70 80 90 100 110 120 QSMPTPPYAT LNPYAYAPAI APHLAARRAG RIPTLDALVA HVADPLAEKR DLTLIEGAGG 130 140 150 160 170 180 WRVPLNDDED LAGLAVRLEL PVILVVGLEL GCLNHARLSA EAIRADGLPL AGWVGNLIDP 190 200 210 220 230 GLSFDEVADE ACYRDNLATL ERTLEAPCLG IVPRLAAATP DARAHAAADY LTLPGDA

References

[1]

"Complete sequence of Chromohalobacter salexigens DSM 3043." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Saunders E., Schmutz J. , Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Csonka L.N., O'Conner K., Vreeland R.H., Oren A., Vargas C., Nieto J., Arahal D.R., Goodner B., Wheeler C., Hall P., Ewing A., Benson L., McBeath D., Canovas D., Richardson P. Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000285 Genomic DNA. Translation: ABE58519.1.
RefSeq	YP_573218.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q1QYD9.
Genome annotation databases
GeneID	4028102.
GenomeReviews	Gene locus Csal_1163 in contig CP000285_GR.
KEGG	csa:Csal_1163.
NMPDR	fig|290398.4.peg.1186.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q1QYD9.
OMA	CLIEGAG.
Enzyme and pathway databases
BioCyc	CSAL290398:CSAL_1163-MON.
Family and domain databases
HAMAP	MF_00336. [Tree]
InterPro	IPR004472. BioD_synth. [Graphical view]
PIRSF	PIRSF006755. DTB_synth. 1 hit.
TIGRFAMs	TIGR00347. bioD. 1 hit.
ProtoNet	Search...

Entry information

Entry name

BIOD_CHRSD

Accession

Primary (citable) accession number: Q1QYD9

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	May 16, 2006
Last modified:	November 3, 2009
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)