Reviewed, UniProtKB/Swiss-Prot Q1QXE1 (BETA1_CHRSD)

Names and origin

Protein names

Recommended name:
    Choline dehydrogenase
      Short name=CHD
      Short name=CDH
    EC=1.1.99.1

Gene names

Name:	betA
Ordered Locus Names:	Csal_1514

Organism

Chromohalobacter salexigens (strain DSM 3043 / ATCC BAA-138 / NCIMB 13768) [Complete proteome] [HAMAP]

Taxonomic identifier

290398 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Oceanospirillales › Halomonadaceae › Chromohalobacter

Protein attributes

Sequence length	560 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine By similarity.
Catalytic activity	Choline + acceptor = betaine aldehyde + reduced acceptor. HAMAP MF_00750
Cofactor	FAD By similarity.
Pathway	Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (cytochrome c reductase route): step 1/1. HAMAP MF_00750
Sequence similarities	Belongs to the GMC oxidoreductase family.

Ontologies

Keywords
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycine betaine biosynthetic process from choline Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	FAD binding Inferred from electronic annotation. Source: InterPro choline dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 560	560	Choline dehydrogenase HAMAP MF_00750		PRO_0000245316
Regions
	Nucleotide binding	8 – 37	30	FAD Probable
Sites
	Active site	475	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q1QXE1-1 [UniParc]. Last modified May 16, 2006. Version 1. Checksum: 8C6D127276CBC454	FASTA	560	62,246
	10 20 30 40 50 60 MTQAREYDYI IIGAGSAGNV LATRLTEDPD VQVLLLEAGG PDYRFDFRTQ MPAALAYPLQ 70 80 90 100 110 120 GKRYNWAFET DPEPYMNNRR MECGRGKGLG GSSLINGMCY LRGNALDYDN WAKIPGLEDW 130 140 150 160 170 180 NYLQCLPYFK RAETRDIGPN DYHGGDGPVS VATPKEGNNE LYGAFIRAGI EAGYPATEDV 190 200 210 220 230 240 NGYQQEGFGP MDRTTTPNGR RASTARGYLD IAKQRPNLTI ETHATTDVIE FEGKRAVGVS 250 260 270 280 290 300 YERKGQAQRV RARREVLLCA GAIASPQILQ RSGVGNPEHL EEFDIPVVHE LPGVGENLQD 310 320 330 340 350 360 HLEMYIQYEC KKPISLYPAL KWYNQPKIGA EWLFFGKGIG ASNQFEAAGF IRTNDQEEWP 370 380 390 400 410 420 NLQYHFLPIA ISYNGKSAVQ AHGFQAHVGS MRSMSRGRIR LTSRDPKAAP SILFNYMSHD 430 440 450 460 470 480 KDWQEFRDAI RITREIIEQP TMDEYRGREI SPGPNVQSDA ELDEFVRQHA ETAYHPAGSC 490 500 510 520 530 540 KMGSADDAMA VVDGAGRVHG LEGLRVIDAS IMPVIATGNL NAPTIMIAEK MADKVRGRDP 550 560 LPPAKVDYYV ANGAPARRRA

References

[1]

"Complete sequence of Chromohalobacter salexigens DSM 3043." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Saunders E., Schmutz J. , Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Csonka L.N., O'Conner K., Vreeland R.H., Oren A., Vargas C., Nieto J., Arahal D.R., Goodner B., Wheeler C., Hall P., Ewing A., Benson L., McBeath D., Canovas D., Richardson P. Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000285 Genomic DNA. Translation: ABE58867.1.
RefSeq	YP_573566.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q1QXE1.
Genome annotation databases
GeneID	4029210.
GenomeReviews	Gene locus Csal_1514 in contig CP000285_GR.
KEGG	csa:Csal_1514.
NMPDR	fig|290398.4.peg.2343.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q1QXE1.
OMA	PNLQYHF.
Enzyme and pathway databases
BioCyc	CSAL290398:CSAL_1514-MON.
Family and domain databases
HAMAP	MF_00750. [Tree]
InterPro	IPR011533. Choline_dehydrogenase. IPR012132. GMC_OxRdtase. IPR000172. GMC_OxRdtase_N. IPR007867. GMC_OxRtase_C. [Graphical view]
Pfam	PF05199. GMC_oxred_C. 1 hit. PF00732. GMC_oxred_N. 1 hit. [Graphical view]
PIRSF	PIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMs	TIGR01810. betA. 1 hit.
PROSITE	PS00623. GMC_OXRED_1. 1 hit. PS00624. GMC_OXRED_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BETA1_CHRSD

Accession

Primary (citable) accession number: Q1QXE1

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2006
Last sequence update:	May 16, 2006
Last modified:	November 3, 2009
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)