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Protein

Oxygen-dependent choline dehydrogenase 1

Gene

betA1

Organism
Chromohalobacter salexigens (strain DSM 3043 / ATCC BAA-138 / NCIMB 13768)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate.UniRule annotation

Catalytic activityi

Choline + acceptor = betaine aldehyde + reduced acceptor.UniRule annotation
Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

Cofactori

FADUniRule annotation

Pathwayi: betaine biosynthesis via choline pathway

This protein is involved in step 1 of the subpathway that synthesizes betaine aldehyde from choline (cytochrome c reductase route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Oxygen-dependent choline dehydrogenase 1 (betA1), Oxygen-dependent choline dehydrogenase (betA)
This subpathway is part of the pathway betaine biosynthesis via choline pathway, which is itself part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes betaine aldehyde from choline (cytochrome c reductase route), the pathway betaine biosynthesis via choline pathway and in Amine and polyamine biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei475Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi8 – 37FADUniRule annotationAdd BLAST30

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandFAD, Flavoprotein, NAD

Enzyme and pathway databases

BioCyciCSAL290398:G1GJB-1554-MONOMER
UniPathwayiUPA00529; UER00385

Names & Taxonomyi

Protein namesi
Recommended name:
Oxygen-dependent choline dehydrogenase 1UniRule annotation (EC:1.1.99.1UniRule annotation)
Short name:
CDH 1UniRule annotation
Short name:
CHD 1UniRule annotation
Alternative name(s):
Betaine aldehyde dehydrogenase 1UniRule annotation (EC:1.2.1.8UniRule annotation)
Short name:
BADH 1UniRule annotation
Gene namesi
Name:betA1UniRule annotation
Synonyms:betA
Ordered Locus Names:Csal_1514
OrganismiChromohalobacter salexigens (strain DSM 3043 / ATCC BAA-138 / NCIMB 13768)
Taxonomic identifieri290398 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaOceanospirillalesHalomonadaceaeChromohalobacter
Proteomesi
  • UP000000239 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002453161 – 560Oxygen-dependent choline dehydrogenase 1Add BLAST560

Interactioni

Protein-protein interaction databases

STRINGi290398.Csal_1514

Structurei

3D structure databases

ProteinModelPortaliQ1QXE1
SMRiQ1QXE1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GMC oxidoreductase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CZ6 Bacteria
COG2303 LUCA
HOGENOMiHOG000139600
KOiK00108
OMAiGWDYAHC
OrthoDBiPOG091H04UT

Family and domain databases

Gene3Di3.50.50.60, 4 hits
4.10.450.10, 2 hits
HAMAPiMF_00750 Choline_dehydrogen, 1 hit
InterProiView protein in InterPro
IPR011533 BetA
IPR036188 FAD/NAD-bd_sf
IPR027424 Glucose_Oxidase_domain_2
IPR012132 GMC_OxRdtase
IPR000172 GMC_OxRdtase_N
IPR007867 GMC_OxRtase_C
PANTHERiPTHR11552:SF157 PTHR11552:SF157, 1 hit
PfamiView protein in Pfam
PF05199 GMC_oxred_C, 1 hit
PF00732 GMC_oxred_N, 1 hit
PIRSFiPIRSF000137 Alcohol_oxidase, 1 hit
SUPFAMiSSF51905 SSF51905, 2 hits
TIGRFAMsiTIGR01810 betA, 1 hit
PROSITEiView protein in PROSITE
PS00623 GMC_OXRED_1, 1 hit
PS00624 GMC_OXRED_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q1QXE1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQAREYDYI IIGAGSAGNV LATRLTEDPD VQVLLLEAGG PDYRFDFRTQ
60 70 80 90 100
MPAALAYPLQ GKRYNWAFET DPEPYMNNRR MECGRGKGLG GSSLINGMCY
110 120 130 140 150
LRGNALDYDN WAKIPGLEDW NYLQCLPYFK RAETRDIGPN DYHGGDGPVS
160 170 180 190 200
VATPKEGNNE LYGAFIRAGI EAGYPATEDV NGYQQEGFGP MDRTTTPNGR
210 220 230 240 250
RASTARGYLD IAKQRPNLTI ETHATTDVIE FEGKRAVGVS YERKGQAQRV
260 270 280 290 300
RARREVLLCA GAIASPQILQ RSGVGNPEHL EEFDIPVVHE LPGVGENLQD
310 320 330 340 350
HLEMYIQYEC KKPISLYPAL KWYNQPKIGA EWLFFGKGIG ASNQFEAAGF
360 370 380 390 400
IRTNDQEEWP NLQYHFLPIA ISYNGKSAVQ AHGFQAHVGS MRSMSRGRIR
410 420 430 440 450
LTSRDPKAAP SILFNYMSHD KDWQEFRDAI RITREIIEQP TMDEYRGREI
460 470 480 490 500
SPGPNVQSDA ELDEFVRQHA ETAYHPAGSC KMGSADDAMA VVDGAGRVHG
510 520 530 540 550
LEGLRVIDAS IMPVIATGNL NAPTIMIAEK MADKVRGRDP LPPAKVDYYV
560
ANGAPARRRA
Length:560
Mass (Da):62,246
Last modified:May 16, 2006 - v1
Checksum:i8C6D127276CBC454
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000285 Genomic DNA Translation: ABE58867.1
RefSeqiWP_011506813.1, NC_007963.1

Genome annotation databases

EnsemblBacteriaiABE58867; ABE58867; Csal_1514
KEGGicsa:Csal_1514

Similar proteinsi

Entry informationi

Entry nameiBETA1_CHRSD
AccessioniPrimary (citable) accession number: Q1QXE1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: May 16, 2006
Last modified: March 28, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health