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Q1QXE1

- BETA1_CHRSD

UniProt

Q1QXE1 - BETA1_CHRSD

Protein

Oxygen-dependent choline dehydrogenase 1

Gene

betA1

Organism
Chromohalobacter salexigens (strain DSM 3043 / ATCC BAA-138 / NCIMB 13768)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (16 May 2006)
      Previous versions | rss
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    Functioni

    Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate.UniRule annotation

    Catalytic activityi

    Choline + acceptor = betaine aldehyde + reduced acceptor.UniRule annotation
    Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

    Cofactori

    FAD.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei475 – 4751UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi8 – 3730FADUniRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-EC
    2. choline dehydrogenase activity Source: UniProtKB-HAMAP
    3. flavin adenine dinucleotide binding Source: InterPro

    GO - Biological processi

    1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    FAD, Flavoprotein, NAD

    Enzyme and pathway databases

    UniPathwayiUPA00529; UER00385.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Oxygen-dependent choline dehydrogenase 1UniRule annotation (EC:1.1.99.1UniRule annotation)
    Short name:
    CDH 1UniRule annotation
    Short name:
    CHD 1UniRule annotation
    Alternative name(s):
    Betaine aldehyde dehydrogenase 1UniRule annotation (EC:1.2.1.8UniRule annotation)
    Short name:
    BADH 1UniRule annotation
    Gene namesi
    Name:betA1UniRule annotation
    Synonyms:betA
    Ordered Locus Names:Csal_1514
    OrganismiChromohalobacter salexigens (strain DSM 3043 / ATCC BAA-138 / NCIMB 13768)
    Taxonomic identifieri290398 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaOceanospirillalesHalomonadaceaeChromohalobacter
    ProteomesiUP000000239: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 560560Oxygen-dependent choline dehydrogenase 1PRO_0000245316Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi290398.Csal_1514.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1QXE1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GMC oxidoreductase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2303.
    HOGENOMiHOG000139600.
    KOiK00108.
    OMAiYLQYACT.
    OrthoDBiEOG67HJQP.

    Family and domain databases

    HAMAPiMF_00750. Choline_dehydrogen.
    InterProiIPR011533. BetA.
    IPR012132. GMC_OxRdtase.
    IPR000172. GMC_OxRdtase_N.
    IPR007867. GMC_OxRtase_C.
    [Graphical view]
    PfamiPF05199. GMC_oxred_C. 1 hit.
    PF00732. GMC_oxred_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000137. Alcohol_oxidase. 1 hit.
    TIGRFAMsiTIGR01810. betA. 1 hit.
    PROSITEiPS00623. GMC_OXRED_1. 1 hit.
    PS00624. GMC_OXRED_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q1QXE1-1 [UniParc]FASTAAdd to Basket

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    MTQAREYDYI IIGAGSAGNV LATRLTEDPD VQVLLLEAGG PDYRFDFRTQ    50
    MPAALAYPLQ GKRYNWAFET DPEPYMNNRR MECGRGKGLG GSSLINGMCY 100
    LRGNALDYDN WAKIPGLEDW NYLQCLPYFK RAETRDIGPN DYHGGDGPVS 150
    VATPKEGNNE LYGAFIRAGI EAGYPATEDV NGYQQEGFGP MDRTTTPNGR 200
    RASTARGYLD IAKQRPNLTI ETHATTDVIE FEGKRAVGVS YERKGQAQRV 250
    RARREVLLCA GAIASPQILQ RSGVGNPEHL EEFDIPVVHE LPGVGENLQD 300
    HLEMYIQYEC KKPISLYPAL KWYNQPKIGA EWLFFGKGIG ASNQFEAAGF 350
    IRTNDQEEWP NLQYHFLPIA ISYNGKSAVQ AHGFQAHVGS MRSMSRGRIR 400
    LTSRDPKAAP SILFNYMSHD KDWQEFRDAI RITREIIEQP TMDEYRGREI 450
    SPGPNVQSDA ELDEFVRQHA ETAYHPAGSC KMGSADDAMA VVDGAGRVHG 500
    LEGLRVIDAS IMPVIATGNL NAPTIMIAEK MADKVRGRDP LPPAKVDYYV 550
    ANGAPARRRA 560
    Length:560
    Mass (Da):62,246
    Last modified:May 16, 2006 - v1
    Checksum:i8C6D127276CBC454
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000285 Genomic DNA. Translation: ABE58867.1.
    RefSeqiYP_573566.1. NC_007963.1.

    Genome annotation databases

    EnsemblBacteriaiABE58867; ABE58867; Csal_1514.
    GeneIDi4029210.
    KEGGicsa:Csal_1514.
    PATRICi21446808. VBIChrSal113723_1521.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000285 Genomic DNA. Translation: ABE58867.1 .
    RefSeqi YP_573566.1. NC_007963.1.

    3D structure databases

    ProteinModelPortali Q1QXE1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 290398.Csal_1514.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABE58867 ; ABE58867 ; Csal_1514 .
    GeneIDi 4029210.
    KEGGi csa:Csal_1514.
    PATRICi 21446808. VBIChrSal113723_1521.

    Phylogenomic databases

    eggNOGi COG2303.
    HOGENOMi HOG000139600.
    KOi K00108.
    OMAi YLQYACT.
    OrthoDBi EOG67HJQP.

    Enzyme and pathway databases

    UniPathwayi UPA00529 ; UER00385 .

    Family and domain databases

    HAMAPi MF_00750. Choline_dehydrogen.
    InterProi IPR011533. BetA.
    IPR012132. GMC_OxRdtase.
    IPR000172. GMC_OxRdtase_N.
    IPR007867. GMC_OxRtase_C.
    [Graphical view ]
    Pfami PF05199. GMC_oxred_C. 1 hit.
    PF00732. GMC_oxred_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000137. Alcohol_oxidase. 1 hit.
    TIGRFAMsi TIGR01810. betA. 1 hit.
    PROSITEi PS00623. GMC_OXRED_1. 1 hit.
    PS00624. GMC_OXRED_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 3043 / ATCC BAA-138 / NCIMB 13768.

    Entry informationi

    Entry nameiBETA1_CHRSD
    AccessioniPrimary (citable) accession number: Q1QXE1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2006
    Last sequence update: May 16, 2006
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3