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Q1QXE1

- BETA1_CHRSD

UniProt

Q1QXE1 - BETA1_CHRSD

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Protein

Oxygen-dependent choline dehydrogenase 1

Gene

betA1

Organism
Chromohalobacter salexigens (strain DSM 3043 / ATCC BAA-138 / NCIMB 13768)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate.UniRule annotation

Catalytic activityi

Choline + acceptor = betaine aldehyde + reduced acceptor.UniRule annotation
Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

Cofactori

FAD.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei475 – 4751UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi8 – 3730FADUniRule annotationAdd
BLAST

GO - Molecular functioni

  1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-EC
  2. choline dehydrogenase activity Source: UniProtKB-HAMAP
  3. flavin adenine dinucleotide binding Source: InterPro

GO - Biological processi

  1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein, NAD

Enzyme and pathway databases

UniPathwayiUPA00529; UER00385.

Names & Taxonomyi

Protein namesi
Recommended name:
Oxygen-dependent choline dehydrogenase 1UniRule annotation (EC:1.1.99.1UniRule annotation)
Short name:
CDH 1UniRule annotation
Short name:
CHD 1UniRule annotation
Alternative name(s):
Betaine aldehyde dehydrogenase 1UniRule annotation (EC:1.2.1.8UniRule annotation)
Short name:
BADH 1UniRule annotation
Gene namesi
Name:betA1UniRule annotation
Synonyms:betA
Ordered Locus Names:Csal_1514
OrganismiChromohalobacter salexigens (strain DSM 3043 / ATCC BAA-138 / NCIMB 13768)
Taxonomic identifieri290398 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaOceanospirillalesHalomonadaceaeChromohalobacter
ProteomesiUP000000239: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 560560Oxygen-dependent choline dehydrogenase 1PRO_0000245316Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi290398.Csal_1514.

Structurei

3D structure databases

ProteinModelPortaliQ1QXE1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GMC oxidoreductase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2303.
HOGENOMiHOG000139600.
KOiK00108.
OMAiYLQYACT.
OrthoDBiEOG67HJQP.

Family and domain databases

HAMAPiMF_00750. Choline_dehydrogen.
InterProiIPR011533. BetA.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view]
PfamiPF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsiTIGR01810. betA. 1 hit.
PROSITEiPS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1QXE1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTQAREYDYI IIGAGSAGNV LATRLTEDPD VQVLLLEAGG PDYRFDFRTQ
60 70 80 90 100
MPAALAYPLQ GKRYNWAFET DPEPYMNNRR MECGRGKGLG GSSLINGMCY
110 120 130 140 150
LRGNALDYDN WAKIPGLEDW NYLQCLPYFK RAETRDIGPN DYHGGDGPVS
160 170 180 190 200
VATPKEGNNE LYGAFIRAGI EAGYPATEDV NGYQQEGFGP MDRTTTPNGR
210 220 230 240 250
RASTARGYLD IAKQRPNLTI ETHATTDVIE FEGKRAVGVS YERKGQAQRV
260 270 280 290 300
RARREVLLCA GAIASPQILQ RSGVGNPEHL EEFDIPVVHE LPGVGENLQD
310 320 330 340 350
HLEMYIQYEC KKPISLYPAL KWYNQPKIGA EWLFFGKGIG ASNQFEAAGF
360 370 380 390 400
IRTNDQEEWP NLQYHFLPIA ISYNGKSAVQ AHGFQAHVGS MRSMSRGRIR
410 420 430 440 450
LTSRDPKAAP SILFNYMSHD KDWQEFRDAI RITREIIEQP TMDEYRGREI
460 470 480 490 500
SPGPNVQSDA ELDEFVRQHA ETAYHPAGSC KMGSADDAMA VVDGAGRVHG
510 520 530 540 550
LEGLRVIDAS IMPVIATGNL NAPTIMIAEK MADKVRGRDP LPPAKVDYYV
560
ANGAPARRRA
Length:560
Mass (Da):62,246
Last modified:May 16, 2006 - v1
Checksum:i8C6D127276CBC454
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000285 Genomic DNA. Translation: ABE58867.1.
RefSeqiYP_573566.1. NC_007963.1.

Genome annotation databases

EnsemblBacteriaiABE58867; ABE58867; Csal_1514.
GeneIDi4029210.
KEGGicsa:Csal_1514.
PATRICi21446808. VBIChrSal113723_1521.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000285 Genomic DNA. Translation: ABE58867.1 .
RefSeqi YP_573566.1. NC_007963.1.

3D structure databases

ProteinModelPortali Q1QXE1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 290398.Csal_1514.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABE58867 ; ABE58867 ; Csal_1514 .
GeneIDi 4029210.
KEGGi csa:Csal_1514.
PATRICi 21446808. VBIChrSal113723_1521.

Phylogenomic databases

eggNOGi COG2303.
HOGENOMi HOG000139600.
KOi K00108.
OMAi YLQYACT.
OrthoDBi EOG67HJQP.

Enzyme and pathway databases

UniPathwayi UPA00529 ; UER00385 .

Family and domain databases

HAMAPi MF_00750. Choline_dehydrogen.
InterProi IPR011533. BetA.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view ]
Pfami PF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsi TIGR01810. betA. 1 hit.
PROSITEi PS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 3043 / ATCC BAA-138 / NCIMB 13768.

Entry informationi

Entry nameiBETA1_CHRSD
AccessioniPrimary (citable) accession number: Q1QXE1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: May 16, 2006
Last modified: October 1, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3