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Q1QXE1

- BETA1_CHRSD

UniProt

Q1QXE1 - BETA1_CHRSD

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Protein

Oxygen-dependent choline dehydrogenase 1

Gene
betA1, betA, Csal_1514
Organism
Chromohalobacter salexigens (strain DSM 3043 / ATCC BAA-138 / NCIMB 13768)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate By similarity.UniRule annotation

Catalytic activityi

Choline + acceptor = betaine aldehyde + reduced acceptor.UniRule annotation
Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

Cofactori

FAD By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei475 – 4751 By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi8 – 3730FAD By similarityAdd
BLAST

GO - Molecular functioni

  1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-EC
  2. choline dehydrogenase activity Source: UniProtKB-HAMAP
  3. flavin adenine dinucleotide binding Source: InterPro

GO - Biological processi

  1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein, NAD

Enzyme and pathway databases

UniPathwayiUPA00529; UER00385.

Names & Taxonomyi

Protein namesi
Recommended name:
Oxygen-dependent choline dehydrogenase 1 (EC:1.1.99.1)
Short name:
CDH 1
Short name:
CHD 1
Alternative name(s):
Betaine aldehyde dehydrogenase 1 (EC:1.2.1.8)
Short name:
BADH 1
Gene namesi
Name:betA1
Synonyms:betA
Ordered Locus Names:Csal_1514
OrganismiChromohalobacter salexigens (strain DSM 3043 / ATCC BAA-138 / NCIMB 13768)
Taxonomic identifieri290398 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaOceanospirillalesHalomonadaceaeChromohalobacter
ProteomesiUP000000239: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 560560Oxygen-dependent choline dehydrogenase 1UniRule annotationPRO_0000245316Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi290398.Csal_1514.

Structurei

3D structure databases

ProteinModelPortaliQ1QXE1.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2303.
HOGENOMiHOG000139600.
KOiK00108.
OMAiYLQYACT.
OrthoDBiEOG67HJQP.

Family and domain databases

HAMAPiMF_00750. Choline_dehydrogen.
InterProiIPR011533. BetA.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view]
PfamiPF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsiTIGR01810. betA. 1 hit.
PROSITEiPS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1QXE1-1 [UniParc]FASTAAdd to Basket

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MTQAREYDYI IIGAGSAGNV LATRLTEDPD VQVLLLEAGG PDYRFDFRTQ    50
MPAALAYPLQ GKRYNWAFET DPEPYMNNRR MECGRGKGLG GSSLINGMCY 100
LRGNALDYDN WAKIPGLEDW NYLQCLPYFK RAETRDIGPN DYHGGDGPVS 150
VATPKEGNNE LYGAFIRAGI EAGYPATEDV NGYQQEGFGP MDRTTTPNGR 200
RASTARGYLD IAKQRPNLTI ETHATTDVIE FEGKRAVGVS YERKGQAQRV 250
RARREVLLCA GAIASPQILQ RSGVGNPEHL EEFDIPVVHE LPGVGENLQD 300
HLEMYIQYEC KKPISLYPAL KWYNQPKIGA EWLFFGKGIG ASNQFEAAGF 350
IRTNDQEEWP NLQYHFLPIA ISYNGKSAVQ AHGFQAHVGS MRSMSRGRIR 400
LTSRDPKAAP SILFNYMSHD KDWQEFRDAI RITREIIEQP TMDEYRGREI 450
SPGPNVQSDA ELDEFVRQHA ETAYHPAGSC KMGSADDAMA VVDGAGRVHG 500
LEGLRVIDAS IMPVIATGNL NAPTIMIAEK MADKVRGRDP LPPAKVDYYV 550
ANGAPARRRA 560
Length:560
Mass (Da):62,246
Last modified:May 16, 2006 - v1
Checksum:i8C6D127276CBC454
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000285 Genomic DNA. Translation: ABE58867.1.
RefSeqiYP_573566.1. NC_007963.1.

Genome annotation databases

EnsemblBacteriaiABE58867; ABE58867; Csal_1514.
GeneIDi4029210.
KEGGicsa:Csal_1514.
PATRICi21446808. VBIChrSal113723_1521.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000285 Genomic DNA. Translation: ABE58867.1 .
RefSeqi YP_573566.1. NC_007963.1.

3D structure databases

ProteinModelPortali Q1QXE1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 290398.Csal_1514.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABE58867 ; ABE58867 ; Csal_1514 .
GeneIDi 4029210.
KEGGi csa:Csal_1514.
PATRICi 21446808. VBIChrSal113723_1521.

Phylogenomic databases

eggNOGi COG2303.
HOGENOMi HOG000139600.
KOi K00108.
OMAi YLQYACT.
OrthoDBi EOG67HJQP.

Enzyme and pathway databases

UniPathwayi UPA00529 ; UER00385 .

Family and domain databases

HAMAPi MF_00750. Choline_dehydrogen.
InterProi IPR011533. BetA.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view ]
Pfami PF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsi TIGR01810. betA. 1 hit.
PROSITEi PS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 3043 / ATCC BAA-138 / NCIMB 13768.

Entry informationi

Entry nameiBETA1_CHRSD
AccessioniPrimary (citable) accession number: Q1QXE1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: May 16, 2006
Last modified: September 3, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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