Reviewed, UniProtKB/Swiss-Prot Q1QXB4 (PROA_CHRSD)

Names and origin

Protein names

Recommended name:
    Gamma-glutamyl phosphate reductase
      Short name=GPR
    EC=1.2.1.41
Alternative name(s):
    Glutamate-5-semialdehyde dehydrogenase
    Glutamyl-gamma-semialdehyde dehydrogenase
      Short name=GSA dehydrogenase

Gene names

Name:	proA
Ordered Locus Names:	Csal_1541

Organism

Chromohalobacter salexigens (strain DSM 3043 / ATCC BAA-138 / NCIMB 13768) [Complete proteome] [HAMAP]

Taxonomic identifier

290398 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Oceanospirillales › Halomonadaceae › Chromohalobacter

Protein attributes

Sequence length	428 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the NADPH dependent reduction of L-gamma-glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
Catalytic activity	L-glutamate 5-semialdehyde + phosphate + NADP(+) = L-glutamyl 5-phosphate + NADPH.
Pathway	Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2.
Subcellular location	CytoplasmBy similarity.
Sequence similarities	Belongs to the gamma-glutamyl phosphate reductase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Proline biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW proline biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: HAMAP
Molecular function	NADP binding Inferred from electronic annotation. Source: InterPro glutamate-5-semialdehyde dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 428	428	Gamma-glutamyl phosphate reductase		PRO_0000252568

Sequences

	Sequence		Length	Mass (Da)
	Q1QXB4-1 [UniParc]. Last modified May 16, 2006. Version 1. Checksum: 0CDA35B24B1C3070	FASTA	428	45,827
	10 20 30 40 50 60 MALETSAPEI ADVEAYMRAL GERARDASRM LARATTAQKN RALHAMAEAL DAARETLETA 70 80 90 100 110 120 NRRDLEAGRA NGLDEALLDR LALTPARIDS MIEGLRQVAA LPDPVGEIRD MRYLPSGIQV 130 140 150 160 170 180 GKMRVALGVV GIVYESRPNV TVDAASLCLK SGNATILRGG SEAIQSNRAI ADCIRQGLAA 190 200 210 220 230 240 ADLDAACVQV VATTDRAAVG ALIAMPEYVD VIVPRGGKGL IERISRDARV PVIKHLDGVC 250 260 270 280 290 300 HVYVDRAADD AKAVAIADNA KTQRYSPCNT METLLVHVDA APRVLPELAR LYASKGVELR 310 320 330 340 350 360 ACERARAWLA DAVAATEDDW HAEYLAPILA VRVVDSLEEA IAHINTYGSH HTDAIVTESV 370 380 390 400 410 420 TDARRFLAEV DSSSVMVNAS TRFADGFEYG LGAEIGISTD KLHARGPVGL EGLTSEKYIV YGDGHVRS

References

[1]

"Complete sequence of Chromohalobacter salexigens DSM 3043." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Saunders E., Schmutz J. , Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Csonka L.N., O'Conner K., Vreeland R.H., Oren A., Vargas C., Nieto J., Arahal D.R., Goodner B., Wheeler C., Hall P., Ewing A., Benson L., McBeath D., Canovas D., Richardson P. Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000285 Genomic DNA. Translation: ABE58894.1.
RefSeq	YP_573593.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4027639.
GenomeReviews	Gene locus Csal_1541 in contig CP000285_GR.
KEGG	csa:Csal_1541.
NMPDR	fig|290398.4.peg.2596.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q1QXB4.
Enzyme and pathway databases
BioCyc	CSAL290398:CSAL_1541-MON.
Family and domain databases
HAMAP	MF_00412. [Tree]
InterPro	IPR016163. Ald_DHase_C. IPR016162. Ald_DHase_N. IPR000965. Gglut_pp_reduct. IPR012134. Glu-5-SA_DHase. [Graphical view]
Gene3D	G3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit. G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11063:SF1. GSA_DH. 1 hit.
PIRSF	PIRSF000151. GPR. 1 hit.
TIGRFAMs	TIGR00407. proA. 1 hit.
PROSITE	PS01223. PROA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PROA_CHRSD

Accession

Primary (citable) accession number: Q1QXB4

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 17, 2006
Last sequence update:	May 16, 2006
Last modified:	November 25, 2008
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)