Reviewed, UniProtKB/Swiss-Prot Q1QX78 (STHA_CHRSD)

Names and origin

Protein names

Recommended name:
    Soluble pyridine nucleotide transhydrogenase
      Short name=STH
    EC=1.6.1.1
Alternative name(s):
    NAD(P)(+) transhydrogenase [B-specific]

Gene names

Name:	sthA
Ordered Locus Names:	Csal_1577

Organism

Chromohalobacter salexigens (strain DSM 3043 / ATCC BAA-138 / NCIMB 13768) [Complete proteome] [HAMAP]

Taxonomic identifier

290398 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Oceanospirillales › Halomonadaceae › Chromohalobacter

Protein attributes

Sequence length	463 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation By similarity.
Catalytic activity	NADPH + NAD+ = NADP+ + NADH. HAMAP MF_00247
Cofactor	Binds 1 FAD per subunit By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	FAD Flavoprotein NAD NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	NADP metabolic process Inferred from electronic annotation. Source: HAMAP cell redox homeostasis Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	FAD binding Inferred from electronic annotation. Source: InterPro NAD(P)+ transhydrogenase (B-specific) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 463	463	Soluble pyridine nucleotide transhydrogenase HAMAP MF_00247		PRO_0000260231
Regions
	Nucleotide binding	35 – 44	10	FAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q1QX78-1 [UniParc]. Last modified May 16, 2006. Version 1. Checksum: 6442E282D3757021	FASTA	463	51,953
	10 20 30 40 50 60 MAVHNFDVVV IGSGPAGESA AINAAKHGKR VAIVEKQQAV GGNCTHWGTI PSKALRHQVK 70 80 90 100 110 120 QIMQFNTNRM FRDIGEPRWF SFPRVLERSK VTIDQQVEMR TQFYSRNRIN LFFGVARFRD 130 140 150 160 170 180 EHTLTVRDNQ DGVEELCAQQ FVIATGSRPY RPADINFRHP RIYCSDTILG LSHTPRTLII 190 200 210 220 230 240 FGAGVIGSEY ASIFSGLGVK VDLIDMRERL LSFLDDEISD ALSYHLRQNG VLVRHNEDYE 250 260 270 280 290 300 SIEGDESGVI VKLKSGKRLR ADAFLWANGR TGNTDELGLE NIGLEPNGRG QLQVDEHYRT 310 320 330 340 350 360 MVPHIYAVGD VIGWPSLASA AYDQGRSASD DFLDEDFRFV EDIPTGIYTI PEISSVGKNE 370 380 390 400 410 420 RELTEAKVPY EVAQAFFKDT ARAQITGDTV GMLKILFHRE TLEILGIHCF GDQASEILHI 430 440 450 460 GQAIMQQKGE ANTLKYFINT TFNYPTMAEA YRVAAQNGLN RVF

References

[1]

"Complete sequence of Chromohalobacter salexigens DSM 3043." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Saunders E., Schmutz J. , Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Csonka L.N., O'Conner K., Vreeland R.H., Oren A., Vargas C., Nieto J., Arahal D.R., Goodner B., Wheeler C., Hall P., Ewing A., Benson L., McBeath D., Canovas D., Richardson P. Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000285 Genomic DNA. Translation: ABE58930.1.
RefSeq	YP_573629.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4027596.
GenomeReviews	Gene locus Csal_1577 in contig CP000285_GR.
KEGG	csa:Csal_1577.
NMPDR	fig|290398.4.peg.2933.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q1QX78.
OMA	Q1QX78. EYFVENT.
Enzyme and pathway databases
BioCyc	CSAL290398:CSAL_1577-MON.
Family and domain databases
HAMAP	MF_00247. [Tree]
InterPro	IPR013027. FAD_pyr_nucl-diS_OxRdtase. IPR000815. Hg_reductase. IPR004099. Pyr_nucl-diS_OxRdtase_dimer. IPR001327. Pyr_OxRdtase_NAD_bd. [Graphical view]
Gene3D	G3DSA:3.30.390.30. Pyr_redox_dim. 1 hit.
Pfam	PF00070. Pyr_redox. 1 hit. PF07992. Pyr_redox_2. 1 hit. PF02852. Pyr_redox_dim. 1 hit. [Graphical view]
PRINTS	PR00368. FADPNR. PR00945. HGRDTASE.
ProDom	PD000139. FAD_pyr_redox. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...

Entry information

Entry name

STHA_CHRSD

Accession

Primary (citable) accession number: Q1QX78

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2006
Last sequence update:	May 16, 2006
Last modified:	June 16, 2009
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)