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Q1QWC3 (HIS3_CHRSD) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphoribosyl-AMP cyclohydrolase
Short name=PRA-CH
EC=3.5.4.19
Gene names
Name:hisI
Ordered Locus Names:Csal_1883
OrganismChromohalobacter salexigens (strain DSM 3043 / ATCC BAA-138 / NCIMB 13768) [Complete proteome] [HAMAP]
Taxonomic identifier290398 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Oceanospirillales › Halomonadaceae › Chromohalobacter ›

Protein attributes

Sequence length146 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

1-(5-phosphoribosyl)-AMP + H2O = 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide. HAMAP-Rule MF_01021

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9. HAMAP-Rule MF_01021

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the PRA-CH family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Histidine biosynthesis
   Cellular componentCytoplasm
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processhistidine biosynthetic process

Inferred from electronic annotation. Source: HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionphosphoribosyl-AMP cyclohydrolase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 146146Phosphoribosyl-AMP cyclohydrolase HAMAP-Rule MF_01021
PRO_0000319685

Sequences

Sequence LengthMass (Da)Tools
Q1QWC3 [UniParc].

Last modified May 16, 2006. Version 1.
Checksum: 7EFC0A27953A0AFF

FASTA14616,081
        10         20         30         40         50         60 
MTQRFKQLET AAQGTREATR DLLDAARWND AGLIPAIAQQ HDSGEVLMMA WMNRAALEET 

        70         80         90        100        110        120 
LATGRVCYWS RSRGKPWRKG ESSGQVQQLV TAHLDCDGDT LLLGVDQQGP ACHTGRRSCF 

       130        140 
YVALGADTAH VDSAPLVDPH ELYGER

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000285 Genomic DNA. Translation: ABE59235.1.
RefSeqYP_573934.1. NC_007963.1.

3D structure databases

ProteinModelPortalQ1QWC3.
SMRQ1QWC3. Positions 23-139.
ModBaseSearch...

Protein-protein interaction databases

STRING290398.Csal_1883.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABE59235; ABE59235; Csal_1883.
GeneID4028246.
KEGGcsa:Csal_1883.
PATRIC21447578. VBIChrSal113723_1895.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0139.
HOGENOMHOG000277504.
KOK01496.
OMARSCFYNR.
ProtClustDBPRK00051.

Enzyme and pathway databases

UniPathwayUPA00031; UER00008.

Family and domain databases

HAMAPMF_01021. HisI.
InterProIPR026660. PRA-CH.
IPR002496. PRib_AMP_CycHydrolase_dom.
[Graphical view]
PfamPF01502. PRA-CH. 1 hit.
[Graphical view]
ProDomPD002610. PRA_CycHdrlase. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetSearch...

Entry information

Entry nameHIS3_CHRSD
AccessionPrimary (citable) accession number: Q1QWC3
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: May 16, 2006
Last modified: May 1, 2013
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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