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Q1QWC3

- HIS3_CHRSD

UniProt

Q1QWC3 - HIS3_CHRSD

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Protein
Phosphoribosyl-AMP cyclohydrolase
Gene
hisI, Csal_1883
Organism
Chromohalobacter salexigens (strain DSM 3043 / ATCC BAA-138 / NCIMB 13768)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP By similarity.

Catalytic activityi

1-(5-phospho-beta-D-ribosyl)-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-((5-phospho-beta-D-ribosylamino)methylideneamino)imidazole-4-carboxamide.UniRule annotation

Cofactori

Binds 1 magnesium ion per subunit By similarity.
Binds 1 zinc ion per subunit By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi95 – 951Magnesium By similarity
Metal bindingi96 – 961Zinc; shared with dimeric partner By similarity
Metal bindingi97 – 971Magnesium By similarity
Metal bindingi99 – 991Magnesium By similarity
Metal bindingi112 – 1121Zinc; shared with dimeric partner By similarity
Metal bindingi119 – 1191Zinc; shared with dimeric partner By similarity

GO - Molecular functioni

  1. phosphoribosyl-AMP cyclohydrolase activity Source: UniProtKB-EC

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Magnesium, Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00031; UER00008.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosyl-AMP cyclohydrolase (EC:3.5.4.19)
Short name:
PRA-CH
Gene namesi
Name:hisI
Ordered Locus Names:Csal_1883
OrganismiChromohalobacter salexigens (strain DSM 3043 / ATCC BAA-138 / NCIMB 13768)
Taxonomic identifieri290398 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaOceanospirillalesHalomonadaceaeChromohalobacter
ProteomesiUP000000239: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 146146Phosphoribosyl-AMP cyclohydrolaseUniRule annotation
PRO_0000319685Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

STRINGi290398.Csal_1883.

Structurei

3D structure databases

ProteinModelPortaliQ1QWC3.
SMRiQ1QWC3. Positions 23-139.

Family & Domainsi

Sequence similaritiesi

Belongs to the PRA-CH family.

Phylogenomic databases

eggNOGiCOG0139.
HOGENOMiHOG000277504.
KOiK01496.
OMAiRKACYWS.
OrthoDBiEOG6PGKB6.

Family and domain databases

HAMAPiMF_01021. HisI.
InterProiIPR026660. PRA-CH.
IPR002496. PRib_AMP_CycHydrolase_dom.
[Graphical view]
PfamiPF01502. PRA-CH. 1 hit.
[Graphical view]
ProDomiPD002610. PRA_CycHdrlase. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Q1QWC3-1 [UniParc]FASTAAdd to Basket

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MTQRFKQLET AAQGTREATR DLLDAARWND AGLIPAIAQQ HDSGEVLMMA    50
WMNRAALEET LATGRVCYWS RSRGKPWRKG ESSGQVQQLV TAHLDCDGDT 100
LLLGVDQQGP ACHTGRRSCF YVALGADTAH VDSAPLVDPH ELYGER 146
Length:146
Mass (Da):16,081
Last modified:May 16, 2006 - v1
Checksum:i7EFC0A27953A0AFF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000285 Genomic DNA. Translation: ABE59235.1.
RefSeqiYP_573934.1. NC_007963.1.

Genome annotation databases

EnsemblBacteriaiABE59235; ABE59235; Csal_1883.
GeneIDi4028246.
KEGGicsa:Csal_1883.
PATRICi21447578. VBIChrSal113723_1895.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000285 Genomic DNA. Translation: ABE59235.1 .
RefSeqi YP_573934.1. NC_007963.1.

3D structure databases

ProteinModelPortali Q1QWC3.
SMRi Q1QWC3. Positions 23-139.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 290398.Csal_1883.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABE59235 ; ABE59235 ; Csal_1883 .
GeneIDi 4028246.
KEGGi csa:Csal_1883.
PATRICi 21447578. VBIChrSal113723_1895.

Phylogenomic databases

eggNOGi COG0139.
HOGENOMi HOG000277504.
KOi K01496.
OMAi RKACYWS.
OrthoDBi EOG6PGKB6.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00008 .

Family and domain databases

HAMAPi MF_01021. HisI.
InterProi IPR026660. PRA-CH.
IPR002496. PRib_AMP_CycHydrolase_dom.
[Graphical view ]
Pfami PF01502. PRA-CH. 1 hit.
[Graphical view ]
ProDomi PD002610. PRA_CycHdrlase. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 3043 / ATCC BAA-138 / NCIMB 13768.

Entry informationi

Entry nameiHIS3_CHRSD
AccessioniPrimary (citable) accession number: Q1QWC3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: May 16, 2006
Last modified: September 3, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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