Reviewed, UniProtKB/Swiss-Prot Q1QVQ3 (GLPK_CHRSD)

Names and origin

Protein names

Recommended name:
    Glycerol kinase
    EC=2.7.1.30
Alternative name(s):
    ATP:glycerol 3-phosphotransferase
    Glycerokinase
      Short name=GK

Gene names

Name:	glpK
Ordered Locus Names:	Csal_2104

Organism

Chromohalobacter salexigens (strain DSM 3043 / ATCC BAA-138 / NCIMB 13768) [Complete proteome] [HAMAP]

Taxonomic identifier

290398 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Oceanospirillales › Halomonadaceae › Chromohalobacter

Protein attributes

Sequence length	501 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Key enzyme in the regulation of glycerol uptake and metabolism. HAMAP MF_00186
Catalytic activity	ATP + glycerol = ADP + sn-glycerol 3-phosphate. HAMAP MF_00186
Pathway	Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1. HAMAP MF_00186
Sequence similarities	Belongs to the FGGY kinase family.

Ontologies

Keywords
Biological process	Glycerol metabolism
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro glycerol-3-phosphate metabolic process Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP glycerol kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 501	501	Glycerol kinase HAMAP MF_00186		PRO_1000020717
Regions
	Nucleotide binding	409 – 413	5	ATP By similarity
Sites
	Binding site	12	1	Substrate By similarity
	Binding site	16	1	ATP By similarity
	Binding site	82	1	Substrate By similarity
	Binding site	134	1	Substrate By similarity
	Binding site	243	1	Substrate By similarity
	Binding site	265	1	ATP By similarity
	Binding site	308	1	ATP; via carbonyl oxygen By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q1QVQ3-1 [UniParc]. Last modified May 16, 2006. Version 1. Checksum: 792AC17A5476D062	FASTA	501	55,010
	10 20 30 40 50 60 MHSYLLSIDQ GTTSSRAILF DRQGRVAGVA QEEFAQHFPA SGWVEHDAED IWQSVLRTCR 70 80 90 100 110 120 QVMESTGASI EEIAGIGMTN QRETTLLWDR RTGEPLHRAI VWQDRRTGAY CQSLIDAGHE 130 140 150 160 170 180 AFIQSRTGLL IDPYFSATKL RWLLENVPGA RERAERGELA FGTVDTFLLW RLTGGREHAT 190 200 210 220 230 240 DATNASRTCL FNIHTQQWDE ALLSLFEIPA SLLPEVKDSS ADFGRAEPHW LGGPLPIAGI 250 260 270 280 290 300 AGDQQAALVG QTCFAPGMAK STYGTGCFMI INTGEKAEVS HNRLLTTVAY RLNGKTTYAM 310 320 330 340 350 360 EGSIFVAGAT VQWLRDGLKL FADASETEAL ARQTRAGHGV YLVPAFTGLG APHWDPGARG 370 380 390 400 410 420 AIFGLTRDTG IAEIVAAGLQ AVCYQTRDLQ ACMDDDIEAS AGRLRVDGGM VSNNWVMQFL 430 440 450 460 470 480 ADMLGVPVDR PTVLETTALG AAYLAGLQLG WYADLDEIAG LWRCERTFEP SMEEAERERL 490 500 YRGWLDAIER VKCSAETRGR A

References

[1]

"Complete sequence of Chromohalobacter salexigens DSM 3043." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Saunders E., Schmutz J. , Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Csonka L.N., O'Conner K., Vreeland R.H., Oren A., Vargas C., Nieto J., Arahal D.R., Goodner B., Wheeler C., Hall P., Ewing A., Benson L., McBeath D., Canovas D., Richardson P. Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000285 Genomic DNA. Translation: ABE59455.1.
RefSeq	YP_574154.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4029249.
GenomeReviews	Gene locus Csal_2104 in contig CP000285_GR.
KEGG	csa:Csal_2104.
NMPDR	fig|290398.4.peg.2121.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q1QVQ3.
OMA	Q1QVQ3. KFADNWR.
Enzyme and pathway databases
BioCyc	CSAL290398:CSAL_2104-MON.
Family and domain databases
HAMAP	MF_00186. [Tree]
InterPro	IPR000577. Carb_kinase_FGGY. IPR018485. Carb_kinase_FGGY_C. IPR018483. Carb_kinase_FGGY_CS. IPR018484. Carb_kinase_FGGY_N. IPR005999. Glycerol_kin. [Graphical view]
PANTHER	PTHR10196. FGGY_kin. 1 hit. PTHR10196:SF9. Glycerol_kin. 1 hit.
Pfam	PF02782. FGGY_C. 1 hit. PF00370. FGGY_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR01311. glycerol_kin. 1 hit.
PROSITE	PS00933. FGGY_KINASES_1. 1 hit. PS00445. FGGY_KINASES_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GLPK_CHRSD

Accession

Primary (citable) accession number: Q1QVQ3

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	May 16, 2006
Last modified:	June 16, 2009
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)