Reviewed, UniProtKB/Swiss-Prot Q1QVP5 (PUR5_CHRSD)

Names and origin

Protein names

Recommended name:
    Phosphoribosylformylglycinamidine cyclo-ligase
    EC=6.3.3.1
Alternative name(s):
    AIRS
    Phosphoribosyl-aminoimidazole synthetase
    AIR synthase

Gene names

Name:	purM
Ordered Locus Names:	Csal_2112

Organism

Chromohalobacter salexigens (strain DSM 3043 / ATCC BAA-138 / NCIMB 13768) [Complete proteome] [HAMAP]

Taxonomic identifier

290398 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Oceanospirillales › Halomonadaceae › Chromohalobacter

Protein attributes

Sequence length	358 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole. HAMAP MF_00741
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/5. HAMAP MF_00741
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the AIR synthase family.

Ontologies

Keywords
Biological process	Purine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' IMP biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosylformylglycinamidine cyclo-ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 358	358	Phosphoribosylformylglycinamidine cyclo-ligase HAMAP MF_00741		PRO_0000258346

Sequences

	Sequence		Length	Mass (Da)
	Q1QVP5-1 [UniParc]. Last modified May 16, 2006. Version 1. Checksum: BFEAEF3A2DC47866	FASTA	358	37,887
	10 20 30 40 50 60 MTRSSDTPSS SRASLSYKDA GVDIDAGNAL VERIKGVAKR TSRPEVMGGL GGFGALCQLP 70 80 90 100 110 120 TGYREPVLVS GTDGVGTKLR LAMDLARHDT IGIDLVAMCV NDLVVAGAEP LFFLDYYATG 130 140 150 160 170 180 KLDVDIAADV VTGIGEGCAQ AGCALIGGET AEMPGMYAGS DYDLAGFCVG VVEKSEILDG 190 200 210 220 230 240 SRVAEGDVLL GLASSGPHSN GYSLIRKIIE RGQADLEQEI DGIPLRDALL APTRIYVKSL 250 260 270 280 290 300 LSLIKESDVT VHALSHITGG GLLENVPRVL PDTLAARIDA ASWTRPAVFD WLQREGNVDE 310 320 330 340 350 HEMHRVLNCG IGMVVVVPAA QAERAQAALE AAGETVHRLG EIVPRQDEEE QVRLENVR

References

[1]

"Complete sequence of Chromohalobacter salexigens DSM 3043." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Saunders E., Schmutz J. , Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Csonka L.N., O'Conner K., Vreeland R.H., Oren A., Vargas C., Nieto J., Arahal D.R., Goodner B., Wheeler C., Hall P., Ewing A., Benson L., McBeath D., Canovas D., Richardson P. Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000285 Genomic DNA. Translation: ABE59463.1.
RefSeq	YP_574162.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4029257.
GenomeReviews	Gene locus Csal_2112 in contig CP000285_GR.
KEGG	csa:Csal_2112.
NMPDR	fig|290398.4.peg.2128.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q1QVP5.
OMA	Q1QVP5. MAENAYS.
Enzyme and pathway databases
BioCyc	CSAL290398:CSAL_2112-MON.
Family and domain databases
HAMAP	MF_00741. [Tree]
InterPro	IPR000728. AIR_synth. IPR010918. AIR_synth_C. IPR004733. PurM_cligase. [Graphical view]
Pfam	PF00586. AIRS. 1 hit. PF02769. AIRS_C. 1 hit. [Graphical view]
TIGRFAMs	TIGR00878. purM. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PUR5_CHRSD

Accession

Primary (citable) accession number: Q1QVP5

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	May 16, 2006
Last modified:	June 16, 2009
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)